Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015

Lawn, Joy E; Bahl, Rajiv; Bergström, Staffan; Bhutta, Zulfiqar Ahmed; Darmstadt, Gary L.; Ellis, Matthew; English, Mike; Kurinczuk, Jennifer J; Lee, Anne C C; Merialdi, Mario; Mohamed, Mohamed; Osrin, David; Pattinson, Robert Clive; Paul, Vinod K.; Ramji, Siddarth; Saugstad, Ola Didrik; Sibley, Lyn M.; Singhal, Nalini; Wall, Steven N.; Woods, David; Wyatt, John; Chan, Kit Yee; Rudan, Igor

doi:10.1371/journal.pmed.1000389

Cited by 109 publications

(97 citation statements)

References 40 publications

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“…Brazil has made progress in its prenatal care coverage, and the current challenge is to qualify care in order to promote pregnant women's health and the fetus, ensuring proper diagnosis and interventions to prevent prematurity and infections during pregnancy 30,[33][34] . Worrisome factors are the increasing incidence rates of congenital syphilis -from 2.0/1,000 LB in 2006 to 6.5/1,000 LB in 2015 35 -which is related to the quality of prenatal care, and the appearance of the Zika virus infection 36 .…”

Section: Discussionmentioning

confidence: 99%

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Principais causas da mortalidade na infância no Brasil, em 1990 e 2015: estimativas do estudo de Carga Global de Doença

França

Lansky

Rego

et al. 2017

Rev. bras. epidemiol.

200

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ABSTRACT:Objective: To analyze under-5 mortality rates and leading causes in Brazil and states in 1990 and 2015, using the Global Burden of Disease Study (GBD) 2015 estimates. Methods: The main sources of data for all-causes under-5 mortality and live births estimates were the mortality information system, surveys, and censuses. Proportions and rates per 1,000 live births (LB) were calculated for total deaths and leading causes. Results: Estimates of under-5 deaths in Brazil were 191,505 in 1990, and 51,226 in 2015, 90% of which were infant deaths. The rates per 1,000 LB showed a reduction of 67.6% from 1990 to 2015, achieving the proposed target established by the Millennium Development Goals (MDGs). The reduction generally was more than 60% in states, with a faster reduction in the poorest Northeast region. The ratio of the highest and lowest rates in the states decreased from 4.9 in 1990 to 2.3 in 2015, indicating a reduction in socioeconomic regional disparities. Although prematurity showed a 72% reduction, it still remains as the leading cause of death (COD), followed by diarrheal diseases in 1990, and congenital anomalies, birth asphyxia and septicemia neonatal in 2015. Conclusion: Under-5 mortality has decreased over the past 25 years, with reduction of regional disparities. However, pregnancy and childbirth-related causes remain as major causes of death, together with congenital anomalies. Intersectoral and specific public health policies must be continued to improve living conditions and health care in order to achieve further reduction of under-5 mortality rates in Brazil.

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Section: Discussionmentioning

confidence: 99%

“…The training of hospital professionals caring for newborns, in neonatal reanimation, is an effective strategy for reducing neonatal mortality 33 . The quality of perinatal hospital care needs to be monitored by process indicators, besides perinatal results.…”

Section: Discussionmentioning

confidence: 99%

Principais causas da mortalidade na infância no Brasil, em 1990 e 2015: estimativas do estudo de Carga Global de Doença

França

Lansky

Rego

et al. 2017

Rev. bras. epidemiol.

200

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“…Over 660,000 neonatal deaths are from intrapartum-related events (previously termed "birth asphyxia") and now account for a greater number of under-5 deaths than malaria or HIV (1)(2)(3). The survivors often have significant morbidity and account for 42 million disability-adjusted life-years (DALYs) globally (2,3).…”

Section: Introductionmentioning

confidence: 99%

“…The survivors often have significant morbidity and account for 42 million disability-adjusted life-years (DALYs) globally (2,3). In Kenya, intrapartumrelated deaths are the third leading cause of childhood death (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Using quality improvement to decrease birth asphyxia rates after ‘Helping Babies Breathe’ training in Kenya

et al. 2017

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Aim: The Helping Babies Breathe (HBB) programme is known to decrease neonatal mortality in low-resource settings but gaps in care still exist. This study describes the use of quality improvement to sustain gains in birth asphyxia-related mortality after HBB.Methods: Tenwek Hospital, a rural referral hospital in Kenya, identified high rates of birth asphyxia (BA). They developed a goal to decrease the suspected hypoxic-ischaemic encephalopathy (SHIE) rate by 50% within six months after HBB. Rapid cycles of change were used to test interventions including training, retention and engagement for staff/ trainees and improved data collection. Run charts followed the rate over time, and chi-square analysis was used.

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“…1.3 million infants each year 11 . Four million newborn infants go through birth asphyxia each year, accounting for an estimated 904,000 deaths and 42 million disability-adjusted life years 12 . An equal number develop sequelae following birth asphyxia, most commonly cerebral palsy, epilepsy or sensory deficit 13 .…”

Section: Discussionmentioning

confidence: 99%

Aetiology of Perinatal Mortality- A Study in a Rural Setting

Tayade¹,

Kumar²

2012

Int Jour of Biomed Res

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Background: Each year, an estimated six million perinatal deaths occur worldwide and 98% of them occur in low and middle-income countries. Globally there are 3 major causes of neonatal death: infections (36%), prematurity (28%) and asphyxia (23%). Of the remaining, 7% are due to congenital malformations. Objectives: Analysis of risk factors associated with perinatal mortality and to determine the most common causes of early neonatal deaths. Material and method:The study was carried out at a tertiary care rural hospital of central India. Data were collected on 5,856 births over a one year period. Results: The perinatal mortality rate was 17.07 per 1,000 births. Clinically relevant factors independently associated with perinatal death included: low birth weight, breech presentation, birth asphyxia, sepsis, respiratory distress syndrome, congenital malformations and meconium aspiration syndrome. Over one-half of early neonatal deaths occurred during the first two post natal days, and the most common causes were low birth weight/prematurity (28.80%), asphyxia (13.04%), and congenital malformations (9.23%). Conclusion: Most neonatal deaths occur soon after birth, and nearly three-quarters are caused by low birth weight/prematurity or asphyxia. Neonatal mortality might be reduced by targeting interventions to improve neonatal resuscitation and care of larger preterm infants. Specifically, deaths due to breech presentation, a common risk factor, will be reduced by making available emergency obstetric care. Large number of stillbirths is preventable by regular antenatal check up and institutional delivery.

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Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015

Abstract: Joy Lawn and colleagues used a systematic process developed by the Child Health Nutrition Research Initiative (CHNRI) to define and rank research options to reduce mortality from intrapartum-related neonatal deaths (birth asphyxia) by the year 2015.

Cited by 109 publications

References 40 publications

Principais causas da mortalidade na infância no Brasil, em 1990 e 2015: estimativas do estudo de Carga Global de Doença

Principais causas da mortalidade na infância no Brasil, em 1990 e 2015: estimativas do estudo de Carga Global de Doença

Using quality improvement to decrease birth asphyxia rates after ‘Helping Babies Breathe’ training in Kenya

Aetiology of Perinatal Mortality- A Study in a Rural Setting

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