Flow control in wastewater pressure pipes can reduce energy consumption but increases the risk of sediment formation due to reduced flow velocity. In this work, the sedimentation behavior of dry and wet weather samples at the inflow of a wastewater pumping station is determined by settling column experiments. Based on the derived characteristic settling velocity (vs) distribution, the impact of energy-efficient flow control on sediment formation in pressure pipes (600 mm diameter) was quantified in comparison to a simple on/off operation. In parallel, the sediment formation for 2 years of pumping operation was monitored indirectly via the friction losses. For the investigated case, settling is strongly influenced by the inflow condition (dry, combined from road runoff). Under combined inflow, the proportion of solids with vs from 0.007 to 1.43 mm/s significantly increases. In energy-efficient mode with smoother operation and shorter switch-off sequences, the sediment formation is significant lower. The mean deposit’s height in energy-efficient control was calculated to 0.137 m, while in on/off operation the mean deposit’s height was 0.174 m. No disadvantages arise over a long period by installing the energy-efficient control. The decreased flow lead under the investigated conditions even to a reduced sediment formation.