Seven-membered rings

Meyer, Adam G.; Bissember, Alex C.; Hyland, Christopher J. T.; Williams, Charlotte C.; Szabó, Mónika; Wales, Steven M.; Constable, Grace E. O.; Olivier, Wesley J.

doi:10.1016/b978-0-323-89812-6.00016-x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article2

Book2

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 339 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Transition‐Metal‐Free Radical Relay Cascade Annulation of Amides: Access to Antitumor Active Benzo[b]azepine and Oxindole Derivatives

Sheng,

Qiu,

Wang

et al. 2024

Chemistry A European J

View full text Add to dashboard Cite

Efficient metal‐free synthesis of benzo[b]azepines and oxindoles is achieved via a radical relay cascade strategy employing halogen atom transfer (XAT) for aryl radical generation followed by intramolecular hydrogen atom transfer (HAT). Optimization yielded moderate to substantial yields under visible light irradiation. Preliminary biological assessments revealed promising anti‐tumor activity for select compounds. This study underscores the potential of XAT‐mediated radical relay cascades in medicinal chemistry and anticancer drug discovery.

show abstract