Seven new dammarane triterpenes from the floral spikes of Betula platyphylla var. japonica

Xiong, Juan; Taniguchi, Masatoshi; Kashiwada, Yoshiki; Yamagishi, Takashi; Takaishi, Yoshihisa

doi:10.1007/s11418-010-0462-1

Cited by 13 publications

(4 citation statements)

References 17 publications

(29 reference statements)

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“…However, it has recently been found that mineralized matrixembedded chondrocytes and osteocytes are critical sources of RANKL, which controls osteoclastic resorption in adult bone remodeling. 20) Thus, further studies on the effect of MK on RANKL expression in these cells might provide better understanding of its inhibitory effect.…”

Section: Discussionmentioning

confidence: 99%

(2<i>S</i>)-2′-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling

Kim

et al. 2014

Biological & Pharmaceutical Bulletin

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(2S)-2′-Methoxykurarinone (MK), a compound isolated from the roots of Sophora flavescens, has various physiological properties, such as anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. However, the effect of S. flavescens-derived MK on osteoclastogenesis remains unknown. Therefore, we examined the effect and mechanism of action of MK on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation and bone resorption. MK inhibited osteoclast differentiation in bone marrow cell-osteoblast cocultures but did not affect the RANKL-to-osteoprotegerin ratio induced by osteoclastogenic factors in osteoblasts. MK also inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages in a dose-dependent manner, without cytotoxicity. Pretreatment with MK significantly suppressed the Akt, p38, c-Jun N terminal kinase (JNK), c-Fos, and nuclear factor of activated T cells c1 (NFATc1) pathways and inhibited the bone-resorbing activity of mature osteoclasts. These results collectively suggest that MK inhibits osteoclast differentiation and bone resorption through RANKL-induced mitogen-activated protein kinases (MAPKs) and c-Fos-NFATc1 signaling pathways. Key words (2S)-2′-methoxykurarinone; bone resorption; osteoclast; osteoporosis; receptor activator of nuclear factor-κB ligand (RANKL)Osteoclasts, which originate from hematopoietic cells of the monocyte macrophage lineage, play a crucial role in bone remodeling.1,2) The bone loss in many important skeletal disorders, such as osteoporosis, rheumatoid arthritis, and bone metastases, occurs mainly because of increased osteoclast activity.3,4) Bone formation is regulated by osteoblasts, which also express the receptor activator of nuclear factor kappa-B ligand (RANKL), which has been identified as a member of the tumor necrosis factor (TNF) superfamily and regulates osteoclast differentiation through cell-to-cell contact.3,4) Osteoblasts and stromal cells also produce a soluble decoy receptor for RANKL, osteoprotegerin (OPG), which inhibits osteoclast formation by interrupting the interaction between RANKL and RANK, resulting in an increase in bone density and bone volume.1,2) Several osteoclastogenic factors, such as 1,25-dihydroxyvitamin D 3 (VitD 3 ) and proinflammatory cytokines, can stimulate osteoclast formation by up-regulating the ratio of RANKL to OPG in osteoblasts or stromal cells.

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Section: Discussionmentioning

confidence: 99%

(2<i>S</i>)-2′-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling

Kim

et al. 2014

Biological & Pharmaceutical Bulletin

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“…In order to complete and enrich the resource investigation of DTT, we summarize the literatures (1965–2016) describing this type of triterpenoids, extracted from various botanicals. In Table 1, 136 species, from Araliaceae, Cucurbitaceae, Rhamnaceae, and Meliaceae families, together with 42 others are summarized [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,…”

Section: Plant Resources Of Dttmentioning

confidence: 99%

Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Ruan¹,

Zheng

Lu³

et al. 2016

Molecules

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Dammarane-type triterpenoids (DTT) widely distribute in various medicinal plants. They have generated a great amount of interest in the field of new drug research and development. Generally, DTT are the main bioactive ingredients abundant in Araliaceae plants, such as Panax ginseng, P. japonicas, P. notoginseng, and P. quinquefolium. Aside from Araliaceae, DTT also distribute in other families, including Betulaceae, Cucurbitaceae, Meliaceae, Rhamnaceae, and Scrophulariaceae. Until now, about 136 species belonging to 46 families have been reported to contain DTT. In this article, the genus classifications of plant sources of the botanicals that contain DTT are reviewed, with particular focus on the NMR spectral features and pharmacological activities based on literature reports, which may be benefit for the development of new drugs or food additives.

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“…2) (Freysdottir et al 2011;Grundemann et al 2011;Huh et al 2011). A number of new biologically active compounds have recently been isolated, especially from Asiatic birch (Phan et al 2011;Xiong et al 2011). Secondly, birch pollen causes allergy.…”

Section: Birch (Betula L)mentioning

confidence: 99%

Hybridisation, Introgression and Phylogeography of Icelandic Birch

Anamthawat‐Jónsson¹

2012

Current Topics in Phylogenetics and Phylogeography of Terrestrial and Aquatic Systems

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Seven new dammarane triterpenes from the floral spikes of Betula platyphylla var. japonica

Cited by 13 publications

References 17 publications

(2<i>S</i>)-2′-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling

(2<i>S</i>)-2′-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling

Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Hybridisation, Introgression and Phylogeography of Icelandic Birch

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