Seven years prevalence and distribution of high and low risk HPV genotypes in women living in the metropolitan area of Naples

Martora, Francesca; Pepa, Maria Elena Della; Grimaldi, Elena; Franci, Gianluigi; Folliero, Veronica; Petrillo, Arianna; Schettino, Maria Teresa; Franciscis, Pasquale De; Galdiero, Marilena; Galdiero, Massimiliano

doi:10.1016/j.canep.2019.101625

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…The overall HPV prevalence in women with ASC-US cytology was ~48%, in accordance with other national and international surveys [ 14 , 15 ], and slightly lower than Kjær and Colleagues who reported on a prevalence >70% in individuals with ASCUS and LSIL cytology [ 16 ]. The different prevalence estimates could be associated with the recruited participants, algorithm of screening, and geographical area.…”

Section: Discussionsupporting

confidence: 88%

Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

Muresu

Sotgiu

Marras

et al. 2022

IJERPH

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The assessment of human papillomavirus (HPV) genotype dynamics could support the adoption of more tailored preventive actions against cervical cancer. The aim of the study was to describe the prevalence of HPV infection, HPV genotype distribution, and the epidemiological characteristics of women with ASC-US cytology since the introduction of HPV-DNA testing in Sardinia (Italy), (March 2016–December 2020). Specimens were tested by RT-PCR for 14 high-risk HPV genotypes. A total of 1186 patients were enrolled, with a median (IQR) age of 41 (38–48) years. Of these women, 48.1% were positive for at least one HPV genotype; 311 (26.2%) women were vaccinated with a median (IQR) age of 38 (30/47) years. The percentage of prevalence of HPV-16, -31, -66, -56, and -51 was 36.3%, 18.7%, 11.9%, 11.4% and 10.7%, respectively. The highest prevalence of infection was found in women aged <41 years, and single women. Moreover, women aged >41 years (OR: 0.51, 95% CI: 0.31–0.86; p-value: 0.01), having parity (OR: 0.57, 95% CI: 0.34–0.96, p-value: 0.04), and higher educational level (OR: 0.39, 95% CI: 0.18–0.87; p-value: 0.02) were associated with a lower CIN2+ risk. We did not find a significant difference in terms of prevalence of HPV-16 infection between vaccinated and non-vaccinated (18.3% vs. 17.1%; p-value < 0.001). Our results support the adoption of nonavalent HPV-vaccine to prevent the most prevalent infections caused by HPV-16 and -31 genotypes and underscore the need of surveillance to implement tailored vaccination programs and preventive strategies.

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Section: Discussionsupporting

confidence: 88%

Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

Muresu

Sotgiu

Marras

et al. 2022

IJERPH

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“…In this cross-sectional study in Mexican women, we were able to identify 14 high-risk oncogenic HPV types in 83.43% of participants (302/364 abnormal cervical smears). Their sociodemographic characteristics were similar to those of previous studies [12,13,21]. However, HR-HPV overall prevalence (83.43%) was mildly higher in our study compared to previous reports such as those from Ortega Cervantes et al (2016) [22] and Flores Miramontes et al (2015) [23], with 82.0% and 71.24%, respectively.…”

Section: Discussionsupporting

confidence: 87%

“…Additionally, misidentifying this type by confusing it with type 56, such as with the linear array system [24]. In more recent reports using similar molecular techniques to detect HPV types, a higher prevalence of HPV-66 has been observed than in previous reports [12,13,21].…”

Section: Discussionmentioning

confidence: 99%

“…HPV-66 was originally detected in a biopsy of a 38 year old patient with a stage I invasive squamous-cell carcinoma of the uterine cervix [11]. Several papers have reported the prevalence of HPV-66 between 4.6 -36.5%, predominantly in premalignant lesions [10,12,13]. HPV-66 is an α-PV from species 6 and belonging to a third phylogenetic branch unrelated to types 16 and 18 [14].…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of Human Papillomavirus (HPV) type 66 in low-grade cervical lesions of Mexican women

Juárez-González

Paredes‐Cervantes

Gordillo-Rodríguez³

et al. 2020

Preprint

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Background: HPV-16 infections constitute the highest risk for developing uterine cervix cancer. However, the role of other high-risk types is still controversial. Objective: To analyze HR-HPV prevalence and its possible associations between HPV and risk factors related to cervical lesions among Mexican women. Methods: Cross sectional study using 362 cervical samples collected between 2016 and 2017. Fourteen HR-HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) were detected by highly sensitive PCR amplification followed by reverse hybridization. Bivariate and multivariate analyses were performed to investigate the association between HPV types and risk factors among lesions. Results: Most samples were HR-HPV positive (83.43%). HPV-16 was the most prevalent infection among negative for intraepithelial lesions or malignancy (78.6%), high-grade squamous intraepithelial lesions (50%), and cervical cancer (58.2%). HPV-66 showed an unexpected high prevalence in atypical squamous cells of undetermined significance (50%), low-grade squamous intraepithelial (45.7%), and only found in 3.6% of cervical cancers. HPV-16 was significantly prevalent among women between 30-39 years, whereas types 66 and 52 were significantly associated when previously sexually transmitted disease had occurred (p< 0.05). Conclusions: HPV-66 either in single or co-infection with other HR-HPV types (excluding 16 and 18) might be indicative of non-progressive cancer lesions. HPV-66 prevalence was unusually high in low-grade cervical lesions, predominantly in co-infection with HPV-51, and very low among cervical cancer. This should be addressed to interpret results obtained by methods that group type 66 with other HR-types.

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“…Atualmente, mais de 200 tipos de subtipos de HPV foram identificados, sendo que quase a metade deles infectam o trato genital. Em relação ao papilomavírus humano de alto risco (HPV-AR) oncogênico, são mais frequentes no CECCP os genótipos 16 e 18 (Martora, Della Pepa et al 2019), e dentre estes o HPV-16 é responsável por aproximadamente 90% dos CECOrof induzidos pelo HPV (Menegaldo, Schroeder et al 2020).…”

Section: Ceccp E a Presença Do Hpvunclassified

Caracterização imunoistoquímica das diferenciações neuroendócrina e escamosa em carcinomas espinocelulares da região de cabeça e pescoço

Colturato¹

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RESUMOresultados mostram que dNE pode ser detectada no CECCP, alguns deles associados com HPV-AR, expandindo o seu espectro clinicopatológico. No entanto, estes achados parecem não influenciar a SLD e SG em nossa população de estudo. Futuros estudos no contexto deste trabalho focando interações moleculares entre dNE e HPV-AR no CECCP, bem como análises comparativas com CNEs, são recomendados.Palavras-chave: carcinoma espinocelular; cabeça e pescoço; carcinoma neuroendócrino; diferenciação neuroendócrina; diferenciação escamosa; microarranjo de tecido; HPV; EBV; imunoistoquímica; hibridização in situ.ABSTRACT COLTURATO, CBN. Immunohistochemical characterization of neuroendocrine and squamous differentiations in squamous cell carcinomas of the head and neck region. 2020. 91p. PhD Thesis -

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Seven years prevalence and distribution of high and low risk HPV genotypes in women living in the metropolitan area of Naples

Cited by 10 publications

References 32 publications

Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

High prevalence of Human Papillomavirus (HPV) type 66 in low-grade cervical lesions of Mexican women

Caracterização imunoistoquímica das diferenciações neuroendócrina e escamosa em carcinomas espinocelulares da região de cabeça e pescoço

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