2010
DOI: 10.1038/ng.511
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Several common variants modulate heart rate, PR interval and QRS duration

Abstract: Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), fo… Show more

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Cited by 352 publications
(373 citation statements)
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“…Norwegian biobanks are increasingly contributing to a number of cutting-edge international research projects within e.g. lung cancer, type 2 diabetes, atrial fibrillation and schizophrenia and new projects are under planning (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Biobank Norway will, in the coming years, continue to work for higher sample quality, improved health biobanks and registries, better research and optimized integration with our international biobank partners.…”
Section: Resultsmentioning
confidence: 99%
“…Norwegian biobanks are increasingly contributing to a number of cutting-edge international research projects within e.g. lung cancer, type 2 diabetes, atrial fibrillation and schizophrenia and new projects are under planning (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Biobank Norway will, in the coming years, continue to work for higher sample quality, improved health biobanks and registries, better research and optimized integration with our international biobank partners.…”
Section: Resultsmentioning
confidence: 99%
“…23,24) Only SCN10A polymorphism (rs6795970) was associated with conduction abnormality in two articles. In addition, this P value (P = 9.5 × 10 -59 ) was most significant among the other significant single nucleotide polymorphisms (SNP)s. 24) As a result, we decided to analyze the rs6795970 in the SCN10A, which have been characterized and suggested to be associated with heart block in previous GWAS. Determination of the SCN10A genes genotypes: Genomic DNA was extracted from peripheral blood samples with an extraction kit (Qiagen) according to the manufacturer's protocol.…”
Section: Methodsmentioning
confidence: 99%
“…These data suggest that this polymorphism is not directly associated with the etiology of HCM in Japanese patients. Role of SCN10A polymorphisms in heart block: Various functions have been attributed to the SCN10A as shown in Tables VII, [23][24][25][26]32) VIII, 31,33) and IX. 30) The exact role of the SCN10A polymorphisms is controversial.…”
Section: Frequency Of Polymorphismsmentioning
confidence: 99%
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“…We next considered candidate SNPs identified in previous GWAS on ECG traits [4][5][6][7][19][20][21][22][23] , using both genotype and imputation data (Supplementary Table 3). After the removal of redundant SNPs from the same haplotype (r 2 > 0.2) and the exclusion of the haplotype containing rs10428132, we observed a significant enrichment in association for the remaining 54 markers (P = 5.0 × 10 −8 ; Supplementary Fig.…”
mentioning
confidence: 99%