Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report

Machado‐Alba, Jorge Enrique; Urbano-Garzón, Sivia Fernanda; Gallo-Gómez, Yeinson Nabor; Zuluaica, Sergio; Henao, Yuly; Parrado-Fajardo, Ilsa Yadira

doi:10.1016/j.rcae.2015.11.011

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The condition culminated in cardiorespiratory arrest that required resuscitation maneuvers, orotracheal intubation, defibrillation, and administration of adrenaline, hydrocortisone, and amiodarone. This patient progressed to death [80].…”

Section: Anaphylactic Reactions and General Adverse Effects Of Dipyronementioning

confidence: 90%

One hundred years of dipyrone (metamizole): the recent evidence on its safety

Malheiro

Viana²,

Nascimento³

et al. 2023

PRW

View full text Add to dashboard Cite

Dipyrone is a non-opioid analgesic drug used for fever and many types of pain. Due to the risk of induced agranulocytosis, it was banned in the early 1980s in several countries, but is still widely used in Brazil, Mexico, China and others. This study is a systematic review of literature focusing on the recent evidence about dipyrone safety. To this, a literature search was performed for epidemiological studies published between 2015 and 2022, in English, German, Portuguese, and Spanish languages. From the 30 articles that met the inclusion criteria, most of them consisted in observational studies (n = 27). In children, the frequency of adverse events with dipyrone is low, but can affect the renal and circulatory systems. During pregnancy, the drug doesn't seem to be related to teratogenic abnormalities. Agranulocytosis is still a matter of debate. However, the occurrence is rare, with an estimated risk of 1:1,602. In adults, dipyrone is related to several adverse effects on renal, hepatic, respiratory and epidermal systems. Thus, dipyrone seems to have a low incidence of adverse effects, but some can be considered of high severity. Especially in children, elderly and patients who need treatment for long periods, other analgesic options should be evaluated.

show abstract

Section: Anaphylactic Reactions and General Adverse Effects Of Dipyronementioning

confidence: 90%

One hundred years of dipyrone (metamizole): the recent evidence on its safety

Malheiro

Viana²,

Nascimento³

et al. 2023

PRW

View full text Add to dashboard Cite

show abstract

“…Pravá anafylaktoidní reakce se může vyskytnout i po předchozím bezproblémovém podávání. Má nejčastěji kožní či slizniční projevy, ale vzácně může vést až k srdeční zástavě [19,20].…”

Section: Historie -Jak To Začalounclassified

“…Výskyt anafylaxe po parenterálním podání se udává v širokém rozmezí 1 : 500 až po "vzácné" (tj. ≥ 1/10 000 až < 1/1 000) [20,21].…”

Section: Historie -Jak To Začalounclassified

Metamizole - 100 years since discovery

Málek¹

2020

Anest. intenziv. Med.

View full text Add to dashboard Cite

Klinika anesteziologie a resuscitace 3. lékařské fakulty UK a FN Královské Vinohrady Praha Komise pro historii ČSARIM JEP Článek se věnuje pozoruhodné historii jednoho z neopioidních analgetik-metamizolu. Jeho kořeny sahají až k prvním chemicky připravovaným látkám na konci 19. století. Během století od jeho syntézy prošel obdobím, kdy byl v mnoha zemích zakázán, zatímco v jiných, včetně ČR, se těší značné popularitě a stále tvoří základ multimodální léčby pooperační bolesti.

show abstract

Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report

Cited by 2 publications

References 10 publications

One hundred years of dipyrone (metamizole): the recent evidence on its safety

One hundred years of dipyrone (metamizole): the recent evidence on its safety

Metamizole - 100 years since discovery

Contact Info

Product

Resources

About