Severe ARDS caused by adenovirus: early initiation of ECMO plus continuous renal replacement therapy

Ha, Sang Ook; Kim, Hyoung Soo; Park, Sunghoon; Jung, Ki‐Suck; Jang, Seung Hun; Han, Sang Jin; Kim, Hyun‐Sook; Lee, Sun Hee

doi:10.1186/s40064-016-3571-9

Cited by 15 publications

(18 citation statements)

References 32 publications

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“…According to the current study and case reports in the literature, ARDS therapy secondary to adenovirus includes respiratory support, limited fluid, antiviral drugs, HFOV, ECMO and SRRT (3,4,8,9). Although we started ECMO treatment on the third day of hospitalization, we did not reduce the ventilator's values in accordance with the goal of restraining lungs and preventing the toxic effects of oxygen.…”

Section: Discussionmentioning

confidence: 89%

“…Currently, the efficacy of this drug, which is approved for the treatment of cytomegalovirus retinitis in the patients with Acquired Immune Deficiency Syndrome (AIDS), has not been proven against adenovirus in randomized controlled studies by FDA (Food and Drug Administration). However, in the literature, there are case series and small studies indicating that it is effective in patients with ARDS secondary to adenovirus (3,8,9). Kim et al stated that they had a successful result with the early onset ofcidofovir in seven adult patients with severe pneumonia secondary to adenovirus and with no immunodeficiency (3).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fatal Adenovirus Pneumonia Despite Extracorporeal Life Support Treatments

Yeşilbaş¹,

Şevketoğlu²,

Kıhtır³

et al. 2018

J Pediatr Inf

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Adenovirüs alt solunum yolu enfeksiyonlarının tüm yaşlarda önemli bir etkenidir. Klinik ve laboratuvar olarak diğer virüs ve bakteriyel enfeksiyonlardan ayrımı oldukça zordur. Akut solunum sıkıntısı sendromuna nadiren sebep olsa da diğer etkenlerle karşılaştırıldığında daha yüksek morbidite ve mortaliteye sahiptir. Bu makalede klinik ve laboratuvar bulguları ile bakteriyel pnömoni ön tanısı alan ve hızlı bir şekilde akut solunum sıkıntısı sendromuna ilerleyen çocuk hastada, vücut dışı destek tedavilerine rağmen ölümcül seyreden adenovirüs enfeksiyonundan bahsedilmiştir.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Fatal Adenovirus Pneumonia Despite Extracorporeal Life Support Treatments

Yeşilbaş¹,

Şevketoğlu²,

Kıhtır³

et al. 2018

J Pediatr Inf

View full text Add to dashboard Cite

show abstract

“…Whether high levels of IL-6 and IL-10 in patients with adenovirus infection contribute the worse outcome warrants further investigation. ECMO support for severe adenoviral infection has been reported in several studies [10,33,34] . Retrospective data from the extracorporeal life support organization (ELSO) registry showed that pediatric patients with AV infection supported with ECMO, had a survival to hospital discharge of 38% which was even lower in neonates [8] .B More recently, Ramanathan et al observed over the last 25 years ELSO registry across all age groups who needed ECMO for severe adenoviral pneumonia in neonatal, pediatric, and adult patients, the hospital mortality was 58% with no signi cant improvement from 1992 to 2016 [12] .…”

Section: Discussionmentioning

confidence: 99%

A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU

Shi

Zhong

Wang

et al. 2020

Preprint

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Background: Describe the outcome of adenovirus pneumonia in a pediatric intensive care unit (PICU) over a 3-year period, to identify the risk factors that may be associated with worse outcome.Methods: A retrospective observational study was performed in the PICU of children’s hospital in Shanghai from July 2016 to June 2019. Sixty-seven children over 29 days to 14 years old with adenovirus pneumonia who were admitted to PICU with acute hypoxemic respiratory failure were included in this study. The primary outcome was hospital mortality, and secondary outcomes were hospital and PICU length of stay (LOS), and risk factors of worse outcome.Results: Of 67 children with severe adenovirus pneumonia, the hospital mortality was 16.42 % (11/67) and 28-day mortality was 14.93 % (10/67). Median Pediatric Risk of Mortality III (PRISM III) score at admission was 13 (interquartile range[IQR], 10-15). Median PICU LOS stay was 11days (8-18d) and hospital LOS was 22 days (16-31d). Among children with extracorporeal membrane oxygenation (n=9), 6 cases survived and 3 cases died. The patients who need renal replacement therapy, neuromuscular blockade, parenteral nutrition, and packed red blood cell perfusion had higher hospital mortality ( p = 0.000, p = 0.041, p = 0.000, p = 0.012, respectively). Multivariate logistic analysis indicated that liver dysfunction and nosocomial infection were associated with high risk of mortality.Conclusions: The hospital mortality of adenovirus pneumonia in our PICU was 16.42%. Patients complicated liver dysfunction and co-infection & nosocomial infection were associated with poor outcome.

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Section: Management and Outcomesmentioning

confidence: 99%

A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU

Shi

Zhong

Wang

et al. 2020

Preprint

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Objective: Describe the outcome of adenovirus pneumonia in a pediatric intensive care unit (PICU) over a 3-year period, to identify the risk factors that may be associated with worse outcome. Design: A retrospective observational study was performed in a tertiary university PICU from July 2016 to June 2019. Setting: The PICU of children’s hospital in Shanghai. Patients: Sixty-seven children over 29 days to 14 years old with adenovirus pneumonia who were admitted to PICU with acute hypoxemic respiratory failure were included in this study. Measurements and Main Results: The primary outcome was hospital mortality, and secondary outcomes were hospital and PICU length of stay (LOS), and risk factors of worse outcome. Of 67 children with severe adenovirus pneumonia, the hospital mortality was 16.42 % (11/67) and 28-day mortality was 14.93 % (10/67). Median Pediatric Risk of Mortality III (PRISM III) score at admission was 13 (interquartile range[IQR], 10-15). Median PICU LOS stay was 11days (8-18d) and hospital LOS was 22 days (16-31d). Among children with extracorporeal membrane oxygenation (n=9), 6 cases survived and 3 cases died. The patients who need renal replacement therapy, neuromuscular blockade, parenteral nutrition, and packed red blood cell perfusion had higher hospital mortality ( p = 0.000, p = 0.041, p = 0.000, p = 0.012, respectively). Multivariate logistic analysis indicated that liver dysfunction and co-infection & nosocomial infection were associated with high risk of mortality. Conclusions: The hospital mortality of adenovirus pneumonia in our PICU was 16.42%. Patients complicated liver dysfunction and co-infection & nosocomial infection were associated with poor outcome.

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Severe ARDS caused by adenovirus: early initiation of ECMO plus continuous renal replacement therapy

Cited by 15 publications

References 32 publications

Fatal Adenovirus Pneumonia Despite Extracorporeal Life Support Treatments

Fatal Adenovirus Pneumonia Despite Extracorporeal Life Support Treatments

A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU

A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU

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