Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells

Abstract

Analysis of levels of allergen-specific CD4+ T-cell production of IL-10 in relation to disease severity argues in favour of a role for IL-10 in the control of atopic dermatitis.

Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

“…Several other studies have also found a decreased IL-10 production in allergic compared with non-allergic individuals (Jenmalm et al 2001;Dunstan et al 2005;Seneviratne et al 2006). Altogether, these results may argue for a regulating role of IL-10 in the pathogenesis of allergic disease.…”

Strategies targeting the IL-4/IL-13 axes in disease

“…The proportion of blood eosinophils and IL-13 expressing peripheral CD4 cells in acute paediatric AD is directly proportional to disease severity [199]. Following ex vivo DerP1-stimulation of PBMCs a higher proportion of IL-4 and IL-13 expressing CD4 + cells were found in PBMCs from severe adult AD patients compared with PBMCs from mild patients; mild patient PBMCs also contained more IL-4 and IL-13 expressing CD4 + cells than PBMCs from non-atopic control patients [200].…”

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

“…173 In lesional AD skin, there are increased levels of T H 2 T cells and associated cytokines (IL-4, IL-5, and IL-13), 174 which are also upregulated in nonlesional AD skin 23 and correlate with disease severity. 175 IL-4 and IL-13 induce activated B cells to produce IgE, levels of which are increased in the sera of a majority of patients with AD. 176,177 Hence a predominant T H 2 response characterizes both lesional and nonlesional AD skin and is further induced by ubiquitous environmental agents, which permeate the damaged epidermal barrier.…”