Severe Burns: Pathogenesis and Prevention of Infection

Hurley, James C.

doi:10.1007/15695_2017_32

Cited by 1 publication

(2 citation statements)

References 132 publications

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“…The findings here reinforce and further characterize previous observations in four multi-national surveys [ 1 , 3 , 5 , 140 ]. Rello et al surveyed ICUs in the following four regions: Paris, Barcelona, Montevideo and Seville, and likewise found less variation between the sites in S. aureus -associated VAP than was the case for Acinetobacter -associated VAP [ 141 ]. Another multi-national prospective 24-month survey [ 5 ] was conducted across 55 ICUs of 46 hospitals in Argentina, Brazil, Colombia, India, Mexico, Morocco, Peru and Turkey.…”

Section: Discussionmentioning

confidence: 99%

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World-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression

Hurley

2018

Microorganisms

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Staphylococcus aureus (S. aureus) is a common Ventilator-Associated Pneumonia (VAP) isolate. The objective here is to define the extent and possible reasons for geographic variation in the incidences of S. aureus-associated VAP, MRSA-VAP and overall VAP. A meta-regression model of S. aureus-associated VAP incidence per 1000 Mechanical Ventilation Days (MVD) was undertaken using random effects methods among publications obtained from a search of the English language literature. This model incorporated group level factors such as admission to a trauma ICU, year of publication and use of bronchoscopic sampling towards VAP diagnosis. The search identified 133 publications from seven worldwide regions published over three decades. The summary S. aureus-associated VAP incidence was 4.5 (3.9–5.3) per 1000 MVD. The highest S. aureus-associated VAP incidence is amongst reports from the Mediterranean (mean; 95% confidence interval; 6.1; 4.1–8.5) versus that from Asian ICUs (2.1; 1.5–3.0). The incidence of S. aureus-associated VAP varies by up to three-fold (for the lowest versus highest incidence) among seven geographic regions worldwide, whereas the incidence of VAP varies by less than two-fold. Admission to a trauma unit is the most important group level correlate for S. aureus-associated VAP.

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Section: Discussionmentioning

confidence: 99%

“…However, studies that were undertaken without patient restriction within the context of process improvement for the purpose of general infection prevention were retained in the model and designated ‘intervention period’ studies. Studies that were limited to paediatric, burns [ 141 ] or haemato-oncology ICUs were excluded.…”

Section: Methodsmentioning

confidence: 99%

World-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression

Hurley

2018

Microorganisms

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Severe Burns: Pathogenesis and Prevention of Infection

Cited by 1 publication

References 132 publications

World-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression

World-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression

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