Severe Clostridium diffi cile infection after liver and kidney transplantation

Abstract

Recent statistics have shown increased rates of morbidity and mortality from Clostridium difficile infection worldwide. This problem is mainly typical for surgical patients and is associated with an antibiotic therapy and a prolonged hospital stay. Recipients of solid organs are at a high risk of developing severe forms of C. difficile infection due to immunosupression. Existing recommendations for the treatment of C. difficile infection are based on the severity of the disease and do not consider patients after liver transplantation. The aim of this work is to determine an actual tactics for the diagnosis and treatment of C. difficile in organ recipients in clinical practice.

Clostridium difficile infection in the pediatric patients of an oncological hospital: cultivation of anaerobic intestinal flora and treatment

“…В последние годы в мире наблюдается рост числа инфекционных заболеваний, а также рецидивов и смертности, вызванных Clostridium difficile (Clostridium difficile infection, CDI), среди онкологических больных, поступающих в стационары [1]. В России повышение актуальности выявления клостридий связано с выявлением случаев тяжелого течения Clostridium difficile (C. difficile) диареи с гемоколитом [2] и отнесением пациентов с иммуносупрессией к группе риска развития тяжелых форм CDI [3]. Заболеваемость CDI среди детей растет [4] и составляет уже 25% [5].…”