Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency

Kurvers, Roel A. J.; Westra, Dineke; Heijst, Arno van; Walk, Twiggy L.M.; Warris, Adilia; Kar, Nicole C. A. J. van de

doi:10.1007/s00431-013-2107-3

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…In the immunocompromised population, a case of HIV positive infant twins who presented with Pneumocystis pneumonia at the same time was also reported, [18]. There also been reports a case Bordetella pertussis pneumonia in monozygotic twins with C3 deficiency [19]. However, unlike those in these reported cases, the patients in this report were immunocompetent, based on our routine laboratory studies, and had an almost identical presentation despite their inherent genetic differences.…”

Section: Discussionsupporting

confidence: 55%

Simultaneous Streptococcus pneumoniae empyema in fraternal twins

Galvis

Kamboj

Nakamura

2017

IDCases

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Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia. The current trend in Streptococcus pneumoniae infections has been the rise of multi-drug resistance in the last two decades. We present the case of a pair of 16-month old African-American fraternal twins who presented to the emergency room on the same day for symptoms consistent with pneumonia. Upon further examination, the twins showed remarkably similar symptoms, and cultures revealed penicillin-resistant Streptococcus pneumoniae in both twins. The pneumonia affected both twins in the same way, but a tomography scan did not reveal any shared anatomical abnormalities to account for this near-identical progression. In a review of literature and case reports, there are no reported cases of fraternal twins with simultaneous or non-simultaneous pneumococcal pneumonia or effusions. This case suggests that there may be possible anatomical abnormalities in the fraternal twins which were not evident in routine testing that may have led to near-identical illnesses. The pathophysiology of the simultaneous and near identical infections is not clear but may reflect subtle genetic factors in the siblings.

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Section: Discussionsupporting

confidence: 55%

Simultaneous Streptococcus pneumoniae empyema in fraternal twins

Galvis

Kamboj

Nakamura

2017

IDCases

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“…A recent clinical case report suggested the potential importance of complement mediated bacterial killing in the control of pertussis disease [47]. Therefore, in addition to examining pertussis toxin neutralizing activity, the bactericidal activity of the serum was assessed.…”

Section: Discussionmentioning

confidence: 99%

Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting

et al. 2020

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While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns that compared to wP vaccination, the immune responses to aP vaccination may wane more rapidly. To gain insights into the vaccine elicited immune responses, pre-adult baboons were immunized with either aP or wP vaccines, boosted with an aP vaccine, and observed over a nearly two-year period. Priming with a wP vaccine elicited a more Th17-biased response than priming with aP, whereas priming with an aP vaccine led to a more Th2-biased response than priming with wP. These differences were maintained after aP vaccine boost immunizations. Compared to aP, animals primed with a wP vaccine exhibited greater numbers of pertussis specific memory B cells. While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. Both wP and aP vaccine immunization could induce serum bactericidal activity (SBA); however, only one wP vaccine immunization was required to elicit SBA while multiple aP vaccine immunizations were required to elicit lower, less durable SBA titers. In conclusion, when compared to aP vaccine, priming with wP vaccine elicits distinct cellular and humoral immune responses that persist after aP vaccine boosting.

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“…If it is not controlled in time, it can cause serious damage to the body. [ 4 ] The disease has two characteristics, namely rapid onset and rapid progression. Most of the clinical manifestations include fever, cough, expectoration, wheezing and other symptoms.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine injection for the treatment of viral pneumonia in children

Fang

Pei²,

Mao³

et al. 2021

Medicine

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Background: In recent years, more and more reports are focused on the application of traditional Chinese medicine injection (TCMJ) for the treatment of viral pneumonia. There are about 200 million cases of viral pneumonia worldwide every year, half of which are children. At present, many kinds of TCMJ are created for the treatment of viral pneumonia in children, with good therapeutic effects. However, there are many kinds of TCMJ, and the treatment advantages are different, thus bringing difficulties to the selection of clinical drugs. In order to provide evidence-based evidence support for the clinical selection of TCMJ for the treatment of viral pneumonia in children, this study selected the commonly used TCMJ for clinical treatment of viral pneumonia for meta-analysis to evaluate its efficacy. Methods: The Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang Data, Viper information databases, Cochran library Web of Science, PubMed, MEDLINE and EMBASE will be searched. The literature will be searched, with language restriction in English and Chinese. The related reference will be retrieved as well. Two reviewers will independently extract data and perform quality assessment of included studies. Review Manager 5.3 will be applied to conduct this meta-analysis. Results: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal once we finish this study. Conclusions: This study provides reliable evidence-based evidence for the efficacy of TCMJ in the treatment of viral pneumonia in children. Ethics and dissemination: We will not be allowed to publish private information from individuals. This kind of systematic review should not harm the rights of participants. No ethical approval was required. The results can be published in peer-reviewed journals or at relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/795MB.

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Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency

Abstract: We propose that genetically caused complement disorders should be considered when confronted with severe cases of B. pertussis infection.

Cited by 10 publications

References 10 publications

Simultaneous Streptococcus pneumoniae empyema in fraternal twins

Simultaneous Streptococcus pneumoniae empyema in fraternal twins

Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting

Traditional Chinese medicine injection for the treatment of viral pneumonia in children

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