Severe macular complications in glaucoma: high-resolution multimodal imaging characteristics and review of the literature

Lama, Hugo; Pâques, Michel; Brasnu, Emmanuelle; Vu, Jade; Chaumette, Céline; Dupas, B.; Fardeau, Christine; Chehaibou, Ismaël; Rouland, Jean‐François; Besombes, G.; Labétoulle, Marc; Labbé, Antoine; Rousseau, Antoine

doi:10.1186/s12886-023-03068-z

Cited by 5 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The macula is an extremely delicate region and, consequently, it is particularly susceptible to pathological and degenerative phenomena. Diseases that affect the macula have an immediate negative effect on visual function such as alterations in central visual acuity, with preservation of peripheral vision; reduced contrast sensitivity; changes in the perception of colors, with color appearing dull; and distortion of images [21][22][23][24].…”

Section: The Area Of Maximal Visual Acuitymentioning

confidence: 99%

Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease

Casciano,

Zauli,

Celeghini

et al. 2024

IJMS

View full text Add to dashboard Cite

Neurodegenerative diseases are an increasingly common group of diseases that occur late in life with a significant impact on personal, family, and economic life. Among these, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the major disorders that lead to mild to severe cognitive and physical impairment and dementia. Interestingly, those diseases may show onset of prodromal symptoms early after middle age. Commonly, the evaluation of these neurodegenerative diseases is based on the detection of biomarkers, where functional and structural magnetic resonance imaging (MRI) have shown a central role in revealing early or prodromal phases, although it can be expensive, time-consuming, and not always available. The aforementioned diseases have a common impact on the visual system due to the pathophysiological mechanisms shared between the eye and the brain. In Parkinson’s disease, α-synuclein deposition in the retinal cells, as well as in dopaminergic neurons of the substantia nigra, alters the visual cortex and retinal function, resulting in modifications to the visual field. Similarly, the visual cortex is modified by the neurofibrillary tangles and neuritic amyloid β plaques typically seen in the Alzheimer’s disease brain, and this may reflect the accumulation of these biomarkers in the retina during the early stages of the disease, as seen in postmortem retinas of AD patients. In this light, the ophthalmic evaluation of retinal neurodegeneration could become a cost-effective method for the early diagnosis of those diseases, overcoming the limitations of functional and structural imaging of the deep brain. This analysis is commonly used in ophthalmic practice, and interest in it has risen in recent years. This review will discuss the relationship between Alzheimer’s disease and Parkinson’s disease with retinal degeneration, highlighting how retinal analysis may represent a noninvasive and straightforward method for the early diagnosis of these neurodegenerative diseases.

show abstract

Section: The Area Of Maximal Visual Acuitymentioning

confidence: 99%

Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease

Casciano,

Zauli,

Celeghini

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Tear Moreover, research has underscored the significant role of substantial fluctuations in IOP as a contributing factor to the development of glaucoma [111,112]. However, the routine measurement of IOP using the Goldmann applanation tonometer, a conventional clinical tool, is a complex procedure.…”

Section: Analytesmentioning

confidence: 99%

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Kazanskiy,

Khonina,

Butt

2023

Biosensors

View full text Add to dashboard Cite

According to the age-old adage, while eyes are often considered the gateway to the soul, they might also provide insights into a more pragmatic aspect of our health: blood sugar levels. This potential breakthrough could be realized through the development of smart contact lenses (SCLs). Although contact lenses were first developed for eyesight correction, new uses have recently become available. In the near future, it might be possible to monitor a variety of ocular and systemic disorders using contact lens sensors. Within the realm of glaucoma, SCLs present a novel prospect, offering a potentially superior avenue compared to traditional management techniques. These lenses introduce the possibility of non-invasive and continuous monitoring of intraocular pressure (IOP) while also enabling the personalized administration of medication as and when needed. This convergence holds great promise for advancing glaucoma care. In this review, recent developments in SCLs, including their potential applications, such as IOP and glucose monitoring, are briefly discussed.

show abstract