Severe poisoning with naproxen causing coagulopathy

Lelièvre, Bénédicte; Drouillard, I.; Thill, Chloé; Roux, Gaël Le; Bruneau, Chloé; Mahé, Julien; Deguigne, Marie; Boels, D.

doi:10.1111/bcpt.13365

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Schwaiger et al 15 observed hyaline droplet degeneration of tubular epithelial cells and the occurrence of an interstitial nephritis of the fish kidney when exposed to diclofenac. Lelièvre et al 16 reported the development of cardiovascular shock, hypocoagulability and thrombopenia in a case of a 58-year-old woman who ingested 26 g of naproxen in a suicidal attempt. Walsh et al 17 showed the increased prevalence of abomasal ulceration in Holstein calves when treated with IBF (10-day course).…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Lima

Pegorin

Miranda

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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The incorporation of drugs and bioactive compounds in the natural rubber latex (NRL) matrix has been an alternative for the development of transdermal release membranes. Ibuprofen (IBF) is known to be used to treat inflammatory diseases, but when administered orally, high concentrations can cause some adverse problems. In this work, the incorporation of IBF in the NRL membranes was evaluated by physical-chemical, in vitro permeation, hemocompatibility and molecular modeling assays. In addition, the in vitro release profile of IBF in acid and basic media was analyzed during 96 h. The IBF-NRL membrane exhibited the absence of intermolecular bonding that could hinder drug release and presented compatible mechanical properties for applications as a cutaneous adhesive (0.58 and 1.12 MPa to Young’s modulus and rupture tension, respectively). The IBF-NRL system did not present a significant hemolysis degree (1.67%) within 24 h. The release test indicated that in the first hours of the study, 48.5% IBF was released at basic pH and 22.5% at acidic pH, which is characteristic of a burst effect. Then, a stable release profile was observed until the end of the assay, with total IBF release of 60% in alkaline medium and 50% in acidic medium. The drug permeation results indicated that the IBF-NRL membranes can be used for the local skin treatment with permeation of 3.11% of IBF. Dynamic Molecular simulations indicated a pronounced electric dipole in the ionized form of IBF, which suggests a more effective interaction with water, explaining the efficient drug release in alkaline solutions. In general, the results demonstrate that the IBF-NRL membrane has great potential for a new adhesive that can be used for the treatment of inflammatory processes and injuries.

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Section: Introductionmentioning

confidence: 99%

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Lima

Pegorin

Miranda

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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“…copper-dependent protein stress. Many copper ion carriers are widely used as antitumor drugs, such as quinolin-8-ol, flavonoids, and carbamate(20)(21)(22). Hence, cuproptosis might be a breakthrough strategy for cancer therapy.…”

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confidence: 99%

A cuproptosis-related signature for predicting the prognosis of gastric cancer

He¹,

Zhang²,

Mo³

2023

J Gastrointest Oncol

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Background: Gastric cancer (GC) is one of the most common malignancies. Cuproptosis is a newly discovered type of cell death caused by protein toxicity stress, with copper having considerable importance in GC development.Methods: First, differentially expressed (DE) cuproptosis-related genes (CRGs) were screened in GC. The tumor mutation burden (TMB) of CRGs was analyzed. We then performed enrichment analyses of DE-CRGs. Next, we constructed a GC cuproptosis-related (CR) signature (CRs) using Cox and least absolute shrinkage and selection operator (LASSO) regression analyses. The predictive efficacy was assessed using receiver operating characteristic (ROC) curves. Furthermore, we performed gene set enrichment analysis (GSEA). Different methods were used to assess tumor immunity of the CRs, and the Wilcoxon test was used to examine the expressions of m6A-, m7G-, and ferroptosis-related genes. The "pRRophetic" R package (The R Foundation for Statistical Computing) was used to predict the half maximal inhibitory concentration IC50 of common chemotherapeutic agents. Finally, the expression of CRGs in different clusters was analyzed using single-cell RNA sequencing (scRNA-seq). Results:We identified 8 DE-CRGs in GC. There were 9 CRGs with TMB values >1%. We constructed gene expression networks and CRs for GC. The DE-CRGs were involved in important mitochondrial metabolic pathways, and the CRs was a valuable independent prognosis factor. The GSEA revealed that angiogenesis and metabolic-related pathways were enriched in the high-risk group, whereas the lowrisk group showed enrichment in DNA replication mismatch and repair pathways. The expressions of immunological checkpoints, ferroptosis-, m6A-, and m7G-related genes, type II interferon (INF) response, major histocompatibility complex (MHC class-I), and the IC50 of the copper-based carrier drug elesclomol were significantly different between the 2 groups of the CRs. Furthermore, the scRNA-seq analysis showed that most CRGs were mainly upregulated in endothelial cells. Conclusions:The novel CRs could predict the prognosis of GC.

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“…Sua ação antiinflamatória se deve a mecanismo semelhante ao do naproxeno isoladamente, ou seja, supressão rápida e duradoura (24h) da atividade da COX, com consequente redução da síntese de prostaglandina E2 (PGE2) e tromboxano B2 (TXB2), redução da infiltração leucocitária e da concentração das citocinas inflamatórias, dentre elas, interleucina 6 (IL-6), interleucina 1 beta (IL-1β) e da proteína quimiotática para monócitos 1 (MCP1) (DINGENEN et al, 2019;GLANVILLE et al, 2021). A atuação do ATB-346 sobre a produção de TXB2 pode influenciar a hemostasia, inclusive de forma benéfica na prevenção da formação de trombos, mas isso ainda precisa ser investigado (LELIÈVRE et al, 2019).…”

Section: Atb-346: Possível Efeito Sobre a Formação De Trombosunclassified

Efeito do tratamento com ATB-346, um doador híbrido de H>sub<2>/sub<S, em modelo experimental de trombose induzida em vasos sanguíneos cerebrais de camundongos.

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Severe poisoning with naproxen causing coagulopathy

Cited by 7 publications

References 17 publications

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

A cuproptosis-related signature for predicting the prognosis of gastric cancer

Efeito do tratamento com ATB-346, um doador híbrido de H>sub<2>/sub<S, em modelo experimental de trombose induzida em vasos sanguíneos cerebrais de camundongos.

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