Severe Renal Dysfunction and Risk Factors Associated with Renal Impairment in HIV‐Infected Adults in Africa Initiating Antiretroviral Therapy

Reid, Andrew; Stöhr, Wolfgang; Walker, A. Sarah; Williams, Ian; Kityo, Cissy; Hughes, Peter J.; Kambugu, Andrew; Gilks, Charles F.; Mugyenyi, Peter; Munderi, Paula; Hakim, James; Gibb, Diana

doi:10.1086/533468

Cited by 136 publications

(156 citation statements)

References 28 publications

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“…Some patients with normal kidney function at baseline still progress to CKD stage ≥3 despite HAART, as documented in 1.9 and 1.6% of the patients participating in ALLRT and DART studies, respectively [28,59]. Thus, a kidney biopsy should also be considered in patients on HAART who develop signs of acute kidney injury, those who show progressive kidney failure during therapy, and in those in whom other potentially nephrotoxic drugs (besides those in a HAART regimen) are being used, and whose kidney function fails to improved upon discontinuation of the nephrotoxic agent [17].…”

Section: Limitationsmentioning

confidence: 99%

Treatment of HIV-Associated Nephropathies

Elewa

Sandri

Rizza³

et al. 2011

Nephron Clin Pract

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In patients with HIV, the use of highly active antiretroviral therapy has improved life expectancy. At the same time, this increase in life expectancy has been associated with a higher frequency of chronic kidney disease due to factors other than HIV infection. Besides HIV-associated nephropathy, a number of different types of immune complex and non-immune complex-mediated processes have been identified on kidney biopsies, including vascular disease (nephrosclerosis), diabetes, and drug-related renal injury. In this setting, renal biopsy needs to be considered in order to obtain the correct diagnosis in individual patients with HIV and kidney impairment. Many issues regarding the optimal treatment of the different pathological processes affecting the kidneys of these patients have remained unresolved. Further research is needed in order to optimize treatment and renal outcomes in patients with HIV and kidney disease.

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Section: Limitationsmentioning

confidence: 99%

Treatment of HIV-Associated Nephropathies

Elewa

Sandri

Rizza³

et al. 2011

Nephron Clin Pract

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“…23 A number of observational studies have documented TDF-associated nephrotoxicity following its widespread use in patients. [24][25][26] Four (10%) subjects in this study were suspected to have UTIs. Another study in Nigeria found an increased frequency of UTI in adolescents and young adults with HIV who had advanced clinical WHO stages.…”

Section: Discussionmentioning

confidence: 80%

Persistent proteinuria as an indicator of renal disease in HIV-infected children

Hisbiiyah

Prasetyo

Puspitasari

et al. 2017

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“…This is especially apparent in HIV-infected persons with low CD4 counts and high HIV viral loads at the time of ART initiation and in those with preexisting kidney diseases such as HIVAN [18,19,20]. With the increasing availability of ART, the risk of ESRD in HIV patients has decreased by more than 50% in some populations [10].…”

Section: Overall Art Is Probably Beneficial For Kidney Functionmentioning

confidence: 99%

Renal Disease Associated with Antiretroviral Therapy in the Treatment of HIV

Cooper¹

2011

Nephron Clin Pract

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The introduction of potent combination antiretroviral therapy (ART) in the treatment of HIV infection has permitted reliable control of disease progression and has markedly improved survival among people with HIV. As a result, health care providers and patients have shifted clinical priorities; whereas once delaying opportunistic illness was a primary focus, increasing emphasis is now placed on preventative health, management of comorbid chronic disease and avoiding long-term toxicities of ART. Although renal disease is common in people with HIV, renal disease specifically due to ART remains relatively rare. Still, as the use of ART continues to increase, health care providers are likely to encounter this potentially serious complication with increasing frequency. Distinguishing ART-related nephrotoxicity from the myriad of other potential causes of renal disease in people with HIV is important in order to avoid unnecessary discontinuation of an appropriate ART regimen. This review focuses on the early recognition of renal disease associated with ART and suggests strategies for management and prevention.

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Severe Renal Dysfunction and Risk Factors Associated with Renal Impairment in HIV‐Infected Adults in Africa Initiating Antiretroviral Therapy

Cited by 136 publications

References 28 publications

Treatment of HIV-Associated Nephropathies

Treatment of HIV-Associated Nephropathies

Persistent proteinuria as an indicator of renal disease in HIV-infected children

Renal Disease Associated with Antiretroviral Therapy in the Treatment of HIV

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