Severe sepsis caused by Mobiluncus curtisii subsp. curtisii in a previously healthy female: Case report and review

Hill, David A.; Seaton, R Andrew; Cameron, FL; McLellan, Ailsa; Brown, R.

doi:10.1016/s0163-4453(98)80180-1

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Only one species of anaerobe (Mobiluncus curtisii) has been reported to resist destruction by free-living amoebae (241). This obligate nonsporeforming anaerobic bacterium, causing vaginosis (218) and, more rarely, abcesseses (69) and bacteremia (91,109), persisted for up to 4 to 6 weeks under aerobic conditions as a result of its internalization in Acanthamoeaba (241). Like H. pylori, M. curtisii may multiply aerobically when cocultured with free-living amoebae, while it requires otherwise strict atmospheric conditions for in vitro culture.…”

Section: Other Microorganisms Shown In Vitro To Resistmentioning

confidence: 99%

Microorganisms Resistant to Free-Living Amoebae

2004

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Free-living amoebae feed on bacteria, fungi, and algae. However, some microorganisms have evolved to become resistant to these protists. These amoeba-resistant microorganisms include established pathogens, such as Cryptococcus neoformans, Legionella spp., Chlamydophila pneumoniae, Mycobacterium avium, Listeria monocytogenes, Pseudomonas aeruginosa, and Francisella tularensis, and emerging pathogens, such as Bosea spp., Simkania negevensis, Parachlamydia acanthamoebae, and Legionella-like amoebal pathogens. Some of these amoeba-resistant bacteria (ARB) are lytic for their amoebal host, while others are considered endosymbionts, since a stable host-parasite ratio is maintained. Free-living amoebae represent an important reservoir of ARB and may, while encysted, protect the internalized bacteria from chlorine and other biocides. Free-living amoebae may act as a Trojan horse, bringing hidden ARB within the human “Troy,” and may produce vesicles filled with ARB, increasing their transmission potential. Free-living amoebae may also play a role in the selection of virulence traits and in adaptation to survival in macrophages. Thus, intra-amoebal growth was found to enhance virulence, and similar mechanisms seem to be implicated in the survival of ARB in response to both amoebae and macrophages. Moreover, free-living amoebae represent a useful tool for the culture of some intracellular bacteria and new bacterial species that might be potential emerging pathogens

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Section: Other Microorganisms Shown In Vitro To Resistmentioning

confidence: 99%

Microorganisms Resistant to Free-Living Amoebae

2004

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“…The prevalence of BV in these different populations all over the world ranged between 10-30% (1). BV is associated with several complications of normal childbirth and commonly seen obstetric conditions such as pelvic inflammatory disease (2,3), especially postabortum (4), adverse outcome of pregnancy (5)(6)(7)(8)(9), postpartum endometritis (10) and postoperative cuff cellulitis (11), and possibly with extragenital abscesses (12) and HIV infection (13).…”

mentioning

confidence: 99%

An international study of the interobserver variation between interpretations of vaginal smear criteria of bacterial vaginosis

Forsum

Jakobsson

Larsson

et al. 2002

APMIS

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An international workshop on vaginal smear-based diagnosis of bacterial vaginosis was organized where 13 investigators scoring 258 slides with smears from vaginal fluid. Interobserver reproducibility of interpretations of Nugent scores, Hay/Ison scores and wet smear scores for the diagnosis of bacterial vaginosis was shown to be high. Detailed analysis of individual scoring results however indicated that basic standards of quality control to ensure robust individual readings of slides must be adhered to.

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“…curtisii and Mobiluncus curtisii subsp. holmesii ) [ 1 ]. Mobiluncus curtisii subspecies curtisii is typically a gram-variable, curved rod-shaped, non-spore-forming, motile organism with tapered ends, occurring singly or in pairs with a “gullwing” appearance.…”

Section: Discussionmentioning

confidence: 99%

“…Extragenital infection by Mobiluncus is rare and has been reported in breast abscesses and bacteremia [ 1 ]. To our knowledge, this is only the sixth case of Mobiluncus bacteremia reported in the literature ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Most of the reported cases presented with fever, and all cases had some report of gastrointestinal disturbances, including nausea, diarrhea, vomiting, or abdominal pain. The presumed origin, based upon the case reports of the bacteremia, was the gastrointestinal tract in four patients, including this patient [ 8 , 9 , 10 ], with the other two sources presumed to be uterine [ 11 ] and unknown [ 1 ]. Treatment with an antibiotic led to full recovery in all but one patient.…”

Section: Discussionmentioning

confidence: 99%

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Mobiluncus curtisii Bacteremia: Case Study and Literature Review

Arries

Ferrieri

2022

Infectious Disease Reports

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Background: There are few reports of bacteremia caused by Mobiluncus curtisii in the literature. We present a review of the literature in addition to a case study. Method: We describe the case of an 82-year-old patient who underwent gastrointestinal surgery and subsequently presented with dehydration, nausea, and hyperkalemia secondary to diarrhea. Further clinical work included blood cultures, and the patient was started empirically on piperacillin/tazobactam. Results: After five days, the blood culture bottle showed growth of a gram-variable, curved rod-shaped organism. After culture under anaerobic conditions on sheep blood agar, the organism was identified as Mobiluncus curtisii by MALDI-TOF mass spectrometry and enzymatic technology. A review of the literature reveals five additional cases of Mobiluncus curtisii bacteremia. Conclusions: This is the sixth case in the literature describing Mobiluncus species bacteremia. This organism is rarely identified in blood culture and is most often thought of in the context of bacterial vaginosis. However, the reported cases of bacteremia show gastrointestinal symptoms and presumed gastrointestinal source of infection. The pathogenesis of infection of this organism requires further investigation.

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Severe sepsis caused by Mobiluncus curtisii subsp. curtisii in a previously healthy female: Case report and review

Cited by 11 publications

References 9 publications

Microorganisms Resistant to Free-Living Amoebae

Microorganisms Resistant to Free-Living Amoebae

An international study of the interobserver variation between interpretations of vaginal smear criteria of bacterial vaginosis

Mobiluncus curtisii Bacteremia: Case Study and Literature Review

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