Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Cui, Feihuan; Liu, Qi; Lv, Xiaozhen; Leonhart, Rainer; Tian, Hongjun; Wei, Jing; Zhang, Kerang; Zhu, Gang; Chen, Qiaoling; Wang, Gang; Wang, Xueyi; Zhang, Nan; Huang, Yu; Si, Tianmei; Yu, Xin

doi:10.1186/s12888-021-03194-2

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Similarly, SCZ and the manic phase of BP share the reduced need for sleep [ 103 , 104 , 105 , 106 ]. In MDD and during the depressive phase of BP, patients present both hypersomnia and severe insomnia [ 107 , 108 , 109 , 110 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Monfared

Alhassen

Truong

et al. 2021

Cells

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G-protein-coupled receptors (GPCRs) play an integral role in the neurobiology of psychiatric disorders. Almost all neurotransmitters involved in psychiatric disorders act through GPCRs, and GPCRs are the most common targets of therapeutic drugs currently used in the treatment of psychiatric disorders. However, the roles of GPCRs in the etiology and pathophysiology of psychiatric disorders are not fully understood. Using publically available datasets, we performed a comprehensive analysis of the transcriptomic signatures of G-protein-linked signaling across the major psychiatric disorders: autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD). We also used the BrainSpan transcriptomic dataset of the developing human brain to examine whether GPCRs that exhibit chronological age-associated expressions have a higher tendency to be dysregulated in psychiatric disorders than age-independent GPCRs. We found that most GPCR genes were differentially expressed in the four disorders and that the GPCR superfamily as a gene cluster was overrepresented in the four disorders. We also identified a greater amplitude of gene expression changes in GPCRs than other gene families in the four psychiatric disorders. Further, dysregulated GPCRs overlapped across the four psychiatric disorders, with SCZ exhibiting the highest overlap with the three other disorders. Finally, the results revealed a greater tendency of age-associated GPCRs to be dysregulated in ASD than random GPCRs. Our results substantiate the central role of GPCR signaling pathways in the etiology and pathophysiology of psychiatric disorders. Furthermore, our study suggests that common GPCRs’ signaling may mediate distinct phenotypic presentations across psychiatric disorders. Consequently, targeting these GPCRs could serve as a common therapeutic strategy to treat specific clinical symptoms across psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Monfared

Alhassen

Truong

et al. 2021

Cells

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“…These disruptions manifest as irregular sleep-wake cycles, diurnal mood variations, seasonal fluctuations, changes in eating habits, and alterations in daily social functioning [ 3 ]. Studies have shown a close correlation between circadian rhythm disruptions and the onset, symptomatology, recurrence, and prognosis of MDD [ 4 ]. The disturbance of circadian rhythms represents a significant clinical feature of MDD [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between biological rhythm dysregulation and suicidal ideation in patients with major depressive disorder

Liu,

Zhang,

Ding

et al. 2024

BMC Psychiatry

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Background Although the disturbance of circadian rhythms represents a significant clinical feature of major depressive disorder (MDD), the relationship between biological rhythm disturbances and the severity of suicidal ideation in individuals with MDD remains unclear. We aimed to explore the characteristics of different biological rhythm dimensions in MDD and their association with the severity of depressive symptoms and suicidal ideation. Methods A total of 50 MDD patients and 50 healthy controls were recruited and their general information was collected. The severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HDRS17). The intensity of suicidal ideation was evaluated with the Beck Scale for Suicide Ideation (BSS). The Chinese version of the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) scale was utilized to assess the participants’ biological rhythm dysregulation. Multiple logistic regression analysis was conducted to explore the relationship between biological rhythm and the risk of MDD. Multiple linear regression analysis was performed in the MDD group to investigate the relationship between different biological rhythm dimensions and suicide ideation. Results Significant differences were observed between the MDD group and the control group in total BRIAN score (Z=-5.41, P < 0.001) as well as scores for each dimension. After adjusting for confounding factors, multiple logistic regression analysis revealed a significant association between total BRIAN score and the presence of MDD (OR = 1.20, 95% CI = 1.10–1.29, P < 0.001), as well as between scores in different BRIAN dimensions and the presence of MDD (activity: OR = 1.47, 95% CI = 1.24–1.74, P < 0.001; sleep: OR = 1.52, 95% CI = 1.28–1.79, P < 0.001; social: OR = 1.80, 95% CI = 1.32–2.46, P < 0.001; eating pattern: OR = 1.34, 95% CI = 1.12–1.60, P = 0.001). In patients with MDD, linear regression analysis demonstrated a positive relationship between BSS scores and BRIAN eating pattern scores (β = 0.34, P = 0.022), even after adjusting for demographic factors and the severity of depression. Conclusions Patients with MDD exhibited significantly higher levels of dysregulation in all four biological rhythm dimensions compared to healthy controls and the degree of dysregulation was associated with the severity of depression. More importantly, dysregulation of eating pattern may increase the intensity of suicidal ideation in MDD, thus elevating the risk of suicide.

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Association of evening chronotype, sleep quality and cognitive impairment in patients with major depressive disorder

Wang,

Huo,

Yao

et al. 2024

Front. Psychiatry

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ObjectiveThis study aimed to investigate the independent or synergistic effects of evening chronotype and poor sleep quality on cognitive impairment in patients with major depressive disorder (MDD).MethodsA cross-sectional study was conducted on 249 individuals diagnosed with MDD, recruited from the Mental Health Center of Renmin Hospital of Wuhan University. Chronotype preference was assessed using the reduced Horne and Ostberg Morningness - Eveningness Questionnaire (rMEQ), while sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Cognitive function was evaluated through the Digit Symbol Substitution Test (DSST), defining impairment as a DSST score ≤ 56 (the lowest quartile of the cohort). Univariate analysis and logistic regression models were employed to explore the factors associated with cognitive impairment, focusing on the potential interactive effects of evening chronotype and poor sleep quality.ResultsOf the 249 subjects recruited, about 41% were classified as evening chronotype. These individuals exhibited poorer sleep quality and more severe depressive symptoms compared to non-evening chronotype (p < 0.01). Univariate analysis revealed that first episode status, Hamilton Depression Rating Scale (HAMD-17) scores, evening chronotype, and poor sleep quality were significantly associated with cognitive impairment (p < 0.05). Multivariate logistic regression analysis further demonstrated that the co-existence of evening chronotype and poor sleep quality significantly increased the likelihood of cognitive impairment (adjusted odds ratio [AdjOR] = 2.65, 95% confidence interval [CI] = 1.09–6.45, p < 0.05).ConclusionOur findings suggest that evening chronotype, poor sleep quality, and their interaction are important contributors to cognitive impairment in patients with MDD, alongside the severity of depression and first episode status. These results emphasize the need for integrated approaches targeting circadian rhythm disruptions and sleep disturbances in the treatment of cognitive dysfunction in MDD.

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Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Cited by 3 publications

References 42 publications

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Relationship between biological rhythm dysregulation and suicidal ideation in patients with major depressive disorder

Association of evening chronotype, sleep quality and cognitive impairment in patients with major depressive disorder

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