Severity and depression can impact quality of life in patients with myasthenia gravis

Alanazy, Mohammed H.; Binabbad, Rahaf S; Alromaih, Norah I; Almansour, Raghad A; Alhamdi, Malak F; Alazwary, Naael; Muayqil, Taim

doi:10.1002/mus.26719

Cited by 14 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of drug use characteristics, number of relapses, severe MAUD, and comorbidity with OUD negatively predicted at least one domain of QOL. First, more relapses predicted poorer PHYSQOL and SOCIALQOL, which was consistent with the findings of some recurrent diseases such as acne (53), depression (54) and SUDs (55). Our findings suggested that relapse was an important risk factor for QOL of SUDs patients, especially in their physical and social domains.…”

Section: Discussionsupporting

confidence: 85%

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

et al. 2020

View full text Add to dashboard Cite

Background: The quality of life (QOL) of patients with methamphetamine use disorder (MAUD) is increasingly recognized as an important outcome. Previous studies have found that impulsivity is negatively associated with QOL in mental disorders, but this relationship is rarely confirmed in patients with MAUD. We hypothesized that impulsivity is negatively correlated with QOL in patients with MAUD based on previous findings. In addition, a variety of drug use characteristics of patients that may potentially affect their QOL need to be further explored. Therefore, the purpose of this study was to explore the relationship between impulsivity, multiple drug use characteristics, and QOL in patients with MAUD. Methods: A total of 379 patients with MAUD were recruited, and the majority of them were male (85.5%), with an average age of 33.93 ± 7.08 years. Two psychiatrists conducted semi-structured interviews with methamphetamine (MA) users in two compulsory drug rehabilitation centers to obtain their demographics and drug use characteristics. The Barratt Impulsiveness Scale-11 (BIS-11) and Brief WHO Quality of Life Assessment (WHOQOL-BREF) were used to assess patients' impulsivity and QOL, respectively. Correlation and univariate regression analysis were used to explore the relationships between impulsivity, a series of drug use characteristics and patients' QOL in different domains. Further multiple linear regression analysis was used to identify what extent the above clinical variables explained the variations in patients' QOL. Results: Age, marital status, employment, and various drug use characteristics were significantly associated with at least one QOL domain. Among them, married and full-time job were positively correlated with QOL, while others were negatively correlated with QOL. The total score of BIS-11 was significantly negatively correlated with all four domains of QOL. Impulsivity, a range of drug use characteristics and certain

show abstract

Section: Discussionsupporting

confidence: 85%

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Moreover, frequent relapses with hospitalization or ER visit profoundly affect the quality of life of the patients with MG. Relapse of MG, along with high disease severity and unresponsiveness to treatment, is associated with depression ( 18 , 19 ), and the association between depression and worse quality of life has been consistently suggested in previous reports ( 20 , 21 ). Other study showed that recent relapse of MG itself is associated with low quality of life ( 22 ). In addition, frequent hospitalization also imposes a considerable financial burden to the patients ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis

Kim

Cho

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

Background and purposeAnti-titin antibodies are antistriational antibodies associated with thymoma-associated myasthenia gravis (MG). We evaluated whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated MG than those patients without anti-titin antibody.MethodsPatients with thymoma-associated MG who conducted the serological test for anti-titin antibody were retrospectively included. Disease severity, treatments, MG-related annual hospitalization rate, and MG-related emergency room (ER) visit rate were compared between the patients with anti-titin antibody and those patients without anti-titin antibody. Multivariate analysis was conducted to analyze the association between anti-titin antibody serostatus and multiple admissions (hospitalization or ER visit of ≥2 times).ResultsOf the 64 included patients, 31 (48.4%) patients were positive for anti-titin antibody (titin+ group) and 33 (51.6%) patients were negative for anti-titin antibody (titin– group). Both the annual rate of MG-related hospitalization and ER visit were significantly higher in the titin+ group [0.2 (0.1–0.6) and 0.1 (0–0.2) per year, respectively] than those in the titin– group [0 (0–0.2) and 0 (0–0) per year, p = 0.004 and p = 0.006, respectively]. In multivariate analysis, positive anti-titin antibody was still significantly associated with multiple admissions [odds ratio (OR) 4.11, 95% CI 1.05–16.03] compared to the titin– group as a reference after adjusting for sex, follow-up duration, age at onset, systemic chemotherapy, and the Masaoka staging.ConclusionThe presence of anti-titin antibody is associated with more frequent hospital utilization. Personalized explanation and careful monitoring strategy could be required in patients with thymoma-associated MG with anti-titin antibody for the timely detection of relapses.

show abstract

“…We analyzed 635 single LPE sessions in 276 individual patients, which represent the largest retrospective cohort on LPE therapy to date. Previously, the investigators noticed encouraging therapeutic effects of LPE on several cases of acute systemic lupus erythematosus, rheumatoid arthritis, and acute renal allograft rejection ( 9 , 10 , 17 ). Recently, Luo et al.…”

Section: Discussionmentioning

confidence: 99%

Lymphoplasma Exchange Improves Myasthenia Gravis Exacerbations: A Retrospective Study in a Chinese Center

et al. 2022

View full text Add to dashboard Cite

BackgroundLymphoplasma exchange (LPE), a technique combining plasma exchange with leukapheresis, is emerging as promising treatment for autoimmune diseases. Data on the efficacy and safety of LPE in myasthenia gravis (MG) therapy are scarce. In this study, we aimed to comprehensively review the clinical efficacy, safety, and immunological characteristics of LPE therapy in MG patients.Study Design and MethodsA Chinese cohort of 276 generalized MG patients in state of exacerbation, including impeding crisis, myasthenia crisis, and preparation for thoracic exsection between January 2014 and December 2020, were evaluated in this study.ResultsA total of 276 patients with a median age of 45.5 ± 16.7 years underwent a total of 635 LPE sessions. Clinical scales of Quantitative Myasthenia Gravis (QMG) scores, Myasthenia Gravis Specific Manual Muscle Testing (MMT) scores, activities of daily living (ADL) scores, and quality of life (QOL) scores were improved during 4 weeks’ follow-up. Adverse effects occurred in 20 out of 276 patients, with 14 patients having one adverse event each. Independent predictive factors for good response to LPE therapy were symptom onset before LPE therapy ≤3 days and age on LPE therapy <50 years of age. LPE decreased the serum levels of antibodies, immunoglobulins, and complements 4 weeks after the first replacement, with decreased levels of interleukin (IL)-17A and interferon (IFN)-γ and increased level of IL-10.ConclusionLPE is an effective treatment for MG patients in state of exacerbation and preparation for thymectomy. Early use of LPE on early-onset MG may have good therapeutic effects. The potential mechanism for LPE is the polarization of cytokines from IL-17A, IFN-γ, into IL-10.

show abstract

Severity and depression can impact quality of life in patients with myasthenia gravis

Cited by 14 publications

References 18 publications

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis

Lymphoplasma Exchange Improves Myasthenia Gravis Exacerbations: A Retrospective Study in a Chinese Center

Contact Info

Product

Resources

About