Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study

Abstract

Objective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM.Methods: Adult participants with the diagnosis of VM or probable VM were enrolled according to the 2012 International Headache Society-Bárány Society Criteria. Every outpatient was followed up for 6 months to record the occurrence of VM attacks. Clinical data such as age, sex, number of VM attacks, severity on the visual analog scale, and lipid intake were collected and analyzed. Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Horne and Ostberg Morningness-Eveningness Questionnaires, and Pittsburgh Sleep Quality Index were also administered to find contributing factors.Results: During a 6-month clinical follow-up, 313 VM attack were reported. According to the Visual Analog Scale, the patients were divided into two groups. Then univariate and multivariable analyses were conducted. Among the risk factors, duration of illness (adjusted OR, 1.041; 95% CI, 1.010–1.073; P = 0.009), time of onset: 00:00:00–12:00:00 (adjusted OR, 3.961; 95% CI, 1.966–7.979; P < 0.001) and PSQI scores (adjusted OR, 1.086; 95% CI, 1.002–1.178; P = 0.046) were significantly associated with the severity of VM attack assessed by VAS.Conclusion: The data suggest that patients tended to experienced more severe VM attacks in early hours of a day, especially for those sufferers with longer duration of illness or poor sleep quality. Targeted management of such factors is required to reduce the severity of attacks.

The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018

“…These psychological states can lead to reduced activity, nutritional imbalances, and other health complications, thereby fostering frailty.Lastly, CircS is closely associated with circadian rhythm disruption[ 25 , 30 ], defined as abnormalities in the biological clock’s variables over a 24-hour cycle [ 31 , 32 ]. Studies have shown that circadian rhythms are primarily regulated by the major biological clocks in the suprachiasmatic nucleus (SCN) of the hypothalamus [ 33 ]. Disturbances in circadian rhythms, such as diminished intensity, stability, or increased variability, are strongly linked with an escalated risk of developing frailty and its rapid progression [ 34 ].…”

Assessment of the Balance and Dizziness Objectification in Patients with Vestibular Bilous Headache

“…Механизмы, лежащие в основе ВМ, полностью не изучены. Несмотря на существование разных патогенетических гипотез формирования ВМ, пока не зафиксированы специфические инструментальные маркеры [11,12]. Тем не менее необходимость объективной оценки вестибулярной составляющей ВМ остается.…”

Differences of Sleep Disorders Between Vestibular Migraine and Benign Paroxysmal Positional Vertigo

“…Although its etiology is still needed to be further explored, there may be a certain relationship between sleep disorders and dizziness/vertigo. Vestibular migraine (VM) is a headache disorder with symptoms such as vertigo or dizziness (vestibular symptoms) and is very sensitive to light/sound, headache, and nausea (migraine symptoms) (4). The pathogenesis of VM is still not clear.…”

“…Vestibular migraine (VM) is a headache disorder with symptoms such as vertigo or dizziness (vestibular symptoms) and is very sensitive to light/sound, headache, and nausea (migraine symptoms) ( 4 ). The pathogenesis of VM is still not clear.…”