Severity of constipation related to palonosetron during first-line chemotherapy: a retrospective observational study

Kimura, Sakiko; Hosoya, Kazuhisa; Ogata, Kenji; Furuno, T.; Sogawa, Rintaro; Takeuchi, Koji; Tasaki, Masanobu; Kawaguchi, Atsushı; Nishioka, Atsujiro; Sueoka‐Aragane, Naoko; Noshirο, Hirokazu; Kuratomi, Yuichiro; Yokoyama, Masatoshi; Noguchi, Mitsuru; Anzai, Keizo; Yamashita, Yoshio; Kimura, Shinya; Irié, Hiroyuki

doi:10.1007/s00520-021-06023-0

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional constipation is characterized by slow transit or outlet obstruction, and can be exacerbated by a low fibre diet, immobility, abdominal or pelvic surgery, and medications. Secondary causes include medications such as analgesics (especially opioids), antihypertensives like calcium channel blockers or diuretics, iron supplementation [4], and antiemetic drugs, including serotonin antagonists and anticholinergic drugs [5]. Additionally, chemotherapy can induce both constipation and diarrhoea, with medications such as alkylating agents (cisplatin and oxaliplatin), antimetabolites (gemcitabine), immunomodulating agents (thalidomide), and mitotic inhibitors (vincristine) [6].…”

Section: Introductionmentioning

confidence: 99%

The Role of Rehabilitation in the Treatment of Constipation in Oncological Patients

Chiaramonte

Bonfiglio

Caramma³

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Chemotherapy, as well as opioid and antiemetic drugs, can contribute to constipation in oncological patients. This systematic review aims to analyse the potential of specific rehabilitation strategies and alternative strategies for improving constipation symptoms, with the goal of incorporating these strategies into a dedicated protocol for managing cancer-related constipation. This could potentially reduce the dosages of or eliminate the need for constipation medications. Methods: A systematic search was conducted on PubMed, Scopus and Web of Science. The review included studies analysing constipation complaints in cancer patients treated with rehabilitation, acupuncture and osteopathy. Results: The review included 16 studies in line with PRISMA and PICOS criteria. Most studies showed that physical exercise, abdominal massage, TENS, acupuncture and education on the correct defecation position positively impacted the management of constipation and quality of life in oncological patients. A physiotherapy program involving massages as well as aerobic and resistance training improved constipation in oncological women, regardless of age, sex and frailty. A combination of abdominal massage, abdominal muscle stretching and education on proper defecation position alleviated the severity of constipation and related depression. However, the outcomes regarding TENS were yet inconsistent. Another technique, becoming increasingly common for constipation, and demonstrating positive results, involved stimulating trigger points through acupressure and acupuncture. Conversely, osteopathic and superficial manipulations more frequently required constipation medications than did the other alternative approaches. However, no existing studies have proposed a specific protocol to manage cancer-related constipation. Conclusions: The results of the studies confirm the positive influences of rehabilitation, osteopathy and acupuncture on constipation and pain in oncological patients. Nevertheless, further studies are required to establish the best type, timing and duration of treatment, as well as how the stage and location of the cancer and the cause of constipation (drug-induced or functional) impact the results.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Rehabilitation in the Treatment of Constipation in Oncological Patients

Chiaramonte

Bonfiglio

Caramma³

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Palonosetron for prevention of delayed chemotherapy-induced nausea and vomiting in pediatric patients: a meta-analysis

Yamaguchi,

Saito,

Takekuma

et al. 2023

Support Care Cancer

View full text Add to dashboard Cite

Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report

Yokota,

Akamine,

Kobayashi

et al. 2024

J Pharm Health Care Sci

View full text Add to dashboard Cite

Background Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointestinal obstruction to protect against naldemedine-induced perforation. Here, we report a clinical case of suspected perforation of a diverticulum in the sigmoid colon associated with naldemedine. Case presentation The patient was a 65-year-old man with a history of oral cancer who had been prescribed oxycodone (20 mg/day) for cancer pain. On day 0, the patient started naldemedine 0.2 mg once daily before bedtime for OIC. The dose of oxycodone was increased for pain control up to 60 mg/day. On day 35 of naldemedine treatment, the patient developed fever and abdominal pain, and his frequency of defecation had decreased. Initial laboratory results showed a C-reactive protein (CRP) level of 28.5 mg/dL and white blood cell (WBC) count of 13,500/µL. On day 37, the patient still had tenderness in his lower abdomen. Abdominal computed tomography revealed free air in the abdominal cavity suggesting an intestinal perforation. A Hartmann procedure was performed. Histopathological findings showed numerous diverticula in the sigmoid colon, some of which were perforated. Conclusions These results suggest that the effects of OIC may have compressed the intestinal tract, which was followed by naldemedine-activation of peristalsis, which led to the onset of intestinal perforation. In patients with pre-existing diverticular disease, we should monitor for increased WBC counts and CRP levels after the initiation of treatment with naldemedine, and consider performing appropriate tests early in the event of abdominal complaints.

show abstract

Severity of constipation related to palonosetron during first-line chemotherapy: a retrospective observational study

Cited by 4 publications

References 30 publications

The Role of Rehabilitation in the Treatment of Constipation in Oncological Patients

The Role of Rehabilitation in the Treatment of Constipation in Oncological Patients

Palonosetron for prevention of delayed chemotherapy-induced nausea and vomiting in pediatric patients: a meta-analysis

Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report

Contact Info

Product

Resources

About