Sex- and Age-Dependent Changes in the Adiponectin/Leptin Ratio in Experimental Diet-Induced Obesity in Mice

Becerril, Sara; Rodríguez, Amaia; Moncada, Rafael; Ramírez, Beatriz; Mentxaka, Amaia; Neira, Gabriela; Gómez-Ambrosi, Javier; Frühbeck, Gema

doi:10.3390/nu15010073

Cited by 17 publications

(7 citation statements)

References 52 publications

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“…Relatively high serum leptin levels have been reported in obese and female subjects in both clinical and animal studies, 26,46,47 which is consistent with our results (Table 5). The incidence of obesity has been increasing in ESRD patients, and several studies have shown that it is associated with poor VA maturity 29,48 .…”

Section: Discussionsupporting

confidence: 93%

Elevated plasma leptin levels are associated with vascular access dysfunction in patients on maintenance hemodialysis

Yu,

Tang,

Hung

et al. 2023

Clinical Laboratory Analysis

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BackgroundInflammation has been associated with vascular access (VA) dysfunction. The adipocytokine leptin can directly induce pro‐inflammatory T helper 1 immune responses and the pathogenesis of chronic inflammation. We explored the association between plasma leptin and VA dysfunction in patients on maintenance hemodialysis (HEMO).MethodsA total of 344 consecutive patients who received anastomosis for VA at a single HEMO center between June 1, 2010 and December 31, 2021 were screened. Of these patients, 267 met the inclusion criteria and were included. ELISA was used to measure circulating levels of leptin.ResultsThe VA dysfunction group had a higher leptin level than the patent VA group. A higher concentration of leptin was independently and significantly associated with an elevated risk of VA dysfunction. Multiple logistic regression analysis showed that leptin, female sex, and hypertension were independently associated with VA dysfunction, even after adjusting for known biomarkers. We then evaluated the ability of leptin, female sex, and hypertension to predict the risk of VA dysfunction, and the area under the curve (AUC) for leptin was 0.626 (p = 0.0001). When leptin, female sex, and hypertension were added to this multivariate model, the AUC increased to 0.679 (p = 0.001) for leptin and hypertension, and 0.690 for leptin, hypertension, and female sex (p = 0.004). In addition, plasma leptin levels were associated with sex, body mass index, and hemoglobin.ConclusionsIn addition to the association between leptin and VA dysfunction, hypertension and female sex independently predicted VA dysfunction in patients with HEMO.

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Section: Discussionsupporting

confidence: 93%

Elevated plasma leptin levels are associated with vascular access dysfunction in patients on maintenance hemodialysis

Yu,

Tang,

Hung

et al. 2023

Clinical Laboratory Analysis

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“…Fourth, some previous studies including leptin and adiponectin assessments have reported the adiponectin-to-leptin ratio (ALR), [62,63] while others have reported the LAR [41,42,64-66]. We recommend using the more commonly reported LAR versus the ALR.…”

Section: Reporting Issues and Recommendationsmentioning

confidence: 99%

The Leptin-to-Adiponectin Ratio in Inflammation

Rausch

2024

Current Research in Diabetes & Obesity Journal

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Leptin and adiponectin are adipokines that have been shown to mediate the relationship between systemic inflammation and chronic diseases. However, the inconsistent reporting of leptin and adiponectin data by previous studies hinders the pooling of data across studies for crosspopulation comparisons or meta-analyses. As such, the aims of this brief are to (1) encourage researchers in the area of systemic inflammation to include standardized measures of leptin and adiponectin and the leptin to adiponectin ratio in future studies, and (2) recommend standardized reporting methods. Following standardized measurement and reporting methods will increase the likelihood that new data generated can be compared across studies and thus, knowledge about the impact of these adipokines on inflammation regulation can be advanced.

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“…iWAT, inguinal white adipose tissue; RAGE229, receptor for advanced glycation end products. *p < 0.05; **p < 0.01 [Color figure can be viewed at wileyonlinelibrary.com] fat mass (Figure 4L); however, plasma adiponectin/fat mass and adiponectin/leptin concentration ratio [17][18][19] were significantly higher in mice fed RAGE229-150 ppm diet versus base diet (Figure 4M,N).…”

Section: Administration Of Rage229-150 Ppm Diet To Adult Lean Male Mi...mentioning

confidence: 99%

Pharmacological antagonism of receptor for advanced glycation end products signaling promotes thermogenesis, healthful body mass and composition, and metabolism in mice

Wilson

Arivazhagan

Ruiz

et al. 2023

Obesity

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Objective Optimal body mass and composition as well as metabolic fitness require tightly regulated and interconnected mechanisms across tissues. Disturbances in these regulatory networks tip the balance between metabolic health versus overweight and obesity and their complications. The authors previously demonstrated roles for the receptor for advanced glycation end products (RAGE) in obesity, as global‐ or adipocyte‐specific deletion of Ager (the gene encoding RAGE) protected mice from high‐fat diet‐induced obesity and metabolic dysfunction. Methods To explore translational strategies evoked by these observations, a small molecule antagonist of RAGE signaling, RAGE229, was administered to lean mice and mice with obesity undergoing diet‐induced weight loss. Body mass and composition and whole body and adipose tissue metabolism were examined. Results This study demonstrates that antagonism of RAGE signaling reduced body mass and adiposity and improved glucose, insulin, and lipid metabolism in lean male and female mice and in male mice with obesity undergoing weight loss. In adipose tissue and in human and mouse adipocytes, RAGE229 enhanced phosphorylation of protein kinase A substrates, which augmented lipolysis, mitochondrial function, and thermogenic programs. Conclusions Pharmacological antagonism of RAGE signaling is a potent strategy to optimize healthful body mass and composition and metabolic fitness.

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Sex- and Age-Dependent Changes in the Adiponectin/Leptin Ratio in Experimental Diet-Induced Obesity in Mice

Cited by 17 publications

References 52 publications

Elevated plasma leptin levels are associated with vascular access dysfunction in patients on maintenance hemodialysis

Elevated plasma leptin levels are associated with vascular access dysfunction in patients on maintenance hemodialysis

The Leptin-to-Adiponectin Ratio in Inflammation

Pharmacological antagonism of receptor for advanced glycation end products signaling promotes thermogenesis, healthful body mass and composition, and metabolism in mice

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