Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Allen, Josephine B.; Ludtka, Christopher; James, Bryan D.

doi:10.1146/annurev-bioeng-092222-030857

Cited by 7 publications

(4 citation statements)

References 145 publications

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“…However, these perspectives have been scarcely adopted by the biomedical engineering community. A survey (2017-2022) found that only 53-65% of engineered tissues considered sex and gender aspects [60]. Worse results are obtained when the community of biomaterials is considered, because only ∼4% of studies reported the cell sex, and none included it as a variable of interest [60].…”

Section: Are Natural and Synthetic And Biomaterials Sex-and Gender-su...mentioning

confidence: 99%

“…For example, according to Lock and coworkers [64], the possibility of having female and male engineered myocardial tissues could help to elevate our knowledge on the effect of exogenous exposure to sexual hormones, and this could also improve myocardial health in transgender populations. Sex differences are not limited to cells but also involve micro-environments [60]. Indeed, physical signals (for example, size, shape, porosity, dimensionality) coming from the extracellular matrix are sex-dependent and may be affected by sex hormone stimulation [60].…”

Section: Are Natural and Synthetic And Biomaterials Sex-and Gender-su...mentioning

confidence: 99%

“…Sex differences are not limited to cells but also involve micro-environments [60]. Indeed, physical signals (for example, size, shape, porosity, dimensionality) coming from the extracellular matrix are sex-dependent and may be affected by sex hormone stimulation [60].…”

Section: Are Natural and Synthetic And Biomaterials Sex-and Gender-su...mentioning

confidence: 99%

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The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender

Campesi,

Franconi,

Serra

2024

Life

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Until now, research has been performed mainly in men, with a low recruitment of women; consequentially, biological, physiological, and physio-pathological mechanisms are less understood in women. Obviously, without data obtained on women, it is impossible to apply the results of research appropriately to women. This issue also applies to medical devices (MDs), and numerous problems linked to scarce pre-market research and clinical trials on MDs were evidenced after their introduction to the market. Globally, some MDs are less efficient in women than in men and sometimes MDs are less safe for women than men, although recently there has been a small but significant decrease in the sex and gender gap. As an example, cardiac resynchronization defibrillators seem to produce more beneficial effects in women than in men. It is also important to remember that MDs can impact the health of healthcare providers and this could occur in a sex- and gender-dependent manner. Recently, MDs’ complexity is rising, and to ensure their appropriate use they must have a sex–gender-sensitive approach. Unfortunately, the majority of physicians, healthcare providers, and developers of MDs still believe that the human population is only constituted by men. Therefore, to overcome the gender gap, a real collaboration between the inventors of MDs, health researchers, and health providers should be established to test MDs in female and male tissues, animals, and women.

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Section: Are Natural and Synthetic And Biomaterials Sex-and Gender-su...mentioning

confidence: 99%

Section: Are Natural and Synthetic And Biomaterials Sex-and Gender-su...mentioning

confidence: 99%

See 1 more Smart Citation

The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender

Campesi,

Franconi,

Serra

2024

Life

View full text Add to dashboard Cite

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“…While sex was largely ignored in biomaterials research until recently, [ 267,268 ] some studies have demonstrated sex‐specific differences in host‐biomaterial interactions. For example, females have higher levels of myofibroblast activation and less calcification in aortic valves than males.…”

Section: Impact Of Other Biological Factors On Aging and Biomaterials...mentioning

confidence: 99%

Immunoengineering Biomaterials for Musculoskeletal Tissue Repair across Lifespan

Han,

Rindone,

Elisseeff

2024

Advanced Materials

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Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat musculoskeletal conditions; however, these approaches have yet to make a significant clinical impact. Recent studies have demonstrated that the immune system is central in orchestrating tissue repair and that targeting pro‐regenerative immune responses can improve biomaterial therapeutic outcomes. However, aging is a critical factor negatively affecting musculoskeletal tissue repair and immune function. Hence, understanding how age affects the response to biomaterials is essential for improving musculoskeletal biomaterial therapies. This review focuses on the intersection of the immune system and aging in responding to biomaterials for musculoskeletal tissue repair. The article introduces the general impacts of aging on tissue physiology, the immune system, and the response to biomaterials. Then, it explains how the adaptive immune system guides the response to injury and biomaterial implants in cartilage, muscle, and bone and discusses how aging impacts these processes in each tissue type. The review concludes by highlighting future directions for the development and translation of personalized immunomodulatory biomaterials for musculoskeletal tissue repair.This article is protected by copyright. All rights reserved

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Prolonging Endothelial Cell Survival with Thermoresponsive Peptide‐Functionalized Hydrogels Improves Ischemic Limb Tissue Regeneration and Function

Wang,

Dang,

Rivera‐Bolanos

et al. 2024

Adv Funct Materials

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Critical limb ischemia (CLI) presents a significant clinical challenge, leading to tissue ischemia and potentially resulting in limb necrosis or amputation. Cell‐based regenerative therapies offer promise for improving outcomes in CLI, but their effectiveness is often limited by poor cell survival and engraftment. This study hypothesized that a thermo‐responsive polymer, poly(polyethylene glycol citrate‐co‐N‐isopropylacrylamide) (PPCN), combined with pro‐survival bioactive peptides, can create a protective microenvironment to improve endothelial cell survival and function after their delivery. Through in vitro and in vivo experiments, laminin‐derived peptide A5G81 and vascular endothelial growth factor (VEGF)‐derived peptide QK are identified as effective in promoting endothelial cell spreading, proliferation, and prolonged survival. PPCN's viscoelastic properties protected against shear stress during injection, while the peptides supported endothelial cell behavior through distinct molecular pathways. Importantly, delivery of endothelial cells with PPCN‐A5G81 and PPCN‐QK in a murine hindlimb ischemia model resulted in significant improvements in limb perfusion, tissue preservation, and functional outcomes compared to controls. Additionally, this approach enhanced skeletal muscle remodeling following ischemic injury. This innovative biomaterial platform represents a versatile solution for addressing cell survival challenges and advancing regenerative therapies in CLI and other ischemic conditions.

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Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Cited by 7 publications

References 145 publications

The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender

The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender

Immunoengineering Biomaterials for Musculoskeletal Tissue Repair across Lifespan

Prolonging Endothelial Cell Survival with Thermoresponsive Peptide‐Functionalized Hydrogels Improves Ischemic Limb Tissue Regeneration and Function

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