2023
DOI: 10.21203/rs.3.rs-2489074/v1
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Sex-based differences in IGF1 signaling pathways in response to PAPP-A2 deficiency

Abstract: Background. Patients with pregnancy-associated plasma protein-A2 (PAPP-A2) mutations have progressive postnatal growth retardation and high circulating levels of IGF1 bound in ternary complexes. The present study aims to assess whether Pappa2 deficiency is associated with sex-specific differences in the main components of IGF1 ternary complexes and IGF1 signaling pathways in response to low IGF1 bioavailability. Methods. Plasma, hypothalamus, pituitary gland and liver were analyzed in constitutive Pappa2ko/k… Show more

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