Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity

Fabian, Carly B.; Seney, Marianne L.; Joffe, Max E.

doi:10.1016/bs.irn.2022.10.002

Cited by 5 publications

(1 citation statement)

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“…The group 1 metabotropic glutamate (mGlu) receptors, mGlu 1 and mGlu 5 , are expressed on PFC PV-INs [29][30][31][32] and regulate cellular processes related to membrane physiology, synaptic strength, and endocannabinoid plasticity [33][34][35]. In addition, there are sex differences in signaling and function of mGlu 1 and mGlu 5 receptors [36][37][38]. Here, we tested the hypothesis that mGlu 1 and mGlu 5 receptors mediate sex differences in PFC PV-IN function.…”

Section: Introductionmentioning

confidence: 99%

Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking

Fabian,

Jordan,

Cole

et al. 2023

Preprint

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Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic mechanisms that guide these differences under basal conditions. Proper function of the prefrontal cortex (PFC) is essential for the top-down regulation of motivated behaviors. Activity of the PFC is tightly controlled by parvalbumin-expressing interneurons (PV-INs), a key subpopulation of fast-spiking GABAergic cells that regulate cortical excitability through direct innervations onto the perisomatic regions of nearby pyramidal cells. Recent rodent studies have identified notable sex differences in PV-IN activity and adaptations to experiences such as binge drinking. Here, we investigated the cellular and molecular mechanisms that underlie sex-specific regulation of PFC PV-IN function. Using whole-cell patch clamp electrophysiology and selective pharmacology, we report that PV-INs from female mice are more excitable than those from males. Moreover, we find that mGlu1and mGlu5metabotropic glutamate receptors regulate cell excitability, excitatory drive, and endocannabinoid signaling at PFC PV-INs in a sex-dependent manner. Genetic deletion of mGlu5receptors from PV-expressing cells abrogates all sex differences observed in PV-IN membrane and synaptic physiology. Lastly, we report that female, but not male, PV-mGlu5-/-mice exhibit decreased voluntary drinking on an intermittent access schedule, which could be related to changes in ethanol’s stimulant properties. Importantly, these studies identify mGlu1and mGlu5receptors as candidate signaling molecules involved in sex differences in PV-IN activity and behaviors relevant for alcohol use.

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Section: Introductionmentioning

confidence: 99%

Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking

Fabian,

Jordan,

Cole

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation

Lombardo,

Mondelli,

Worrell

et al. 2024

Journal of Affective Disorders

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Autoradiographic labelling of metabotropic glutamate type 2/3 receptors in the hemi-parkinsonian rat brain

Kim,

Frouni,

Shaqfah

et al. 2024

Journal of Chemical Neuroanatomy

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Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity

Cited by 5 publications

References 207 publications

Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking

Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking

Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation

Autoradiographic labelling of metabotropic glutamate type 2/3 receptors in the hemi-parkinsonian rat brain

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Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity

Cited by 5 publications

References 207 publications

Parvalbumin interneuron mGlu5receptors govern sex differences in prefrontal cortex physiology and binge drinking

Parvalbumin interneuron mGlu5receptors govern sex differences in prefrontal cortex physiology and binge drinking

Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation

Autoradiographic labelling of metabotropic glutamate type 2/3 receptors in the hemi-parkinsonian rat brain

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Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking

Parvalbumin interneuron mGlu₅receptors govern sex differences in prefrontal cortex physiology and binge drinking