Sex differences in behavioral traits related with high sensitivity to the reinforcing effects of cocaine

Pujante-Gil, Sergio; Manzanedo, Carmen; Arenas, M. Carmen

doi:10.1016/j.bbr.2021.113505

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…However, this limitation is balanced by the observation that HR mice showed increased locomotor response to cocaine in the experiments described in Figures 1 and 3 . Previous literature showed sex differences in basal 35 , 36 and cocaine‐induced locomotor activity in rodents, with females showing increased activity. 36 , 37 Our data confirmed these results with female mice showing an overall increased locomotor activity at basal conditions and in response to cocaine.…”

Section: Discussionmentioning

confidence: 92%

“…Previous literature showed sex differences in basal 35 , 36 and cocaine‐induced locomotor activity in rodents, with females showing increased activity. 36 , 37 Our data confirmed these results with female mice showing an overall increased locomotor activity at basal conditions and in response to cocaine. However, sex did not play a role in the genotype differences.…”

Section: Discussionmentioning

confidence: 92%

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Reelin deficiency exacerbates cocaine‐induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum

Guglielmo

Iemolo

Nur

et al. 2022

Genes Brain and Behavior

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The Reln gene encodes for the extracellular glycoprotein Reelin, which regulates several brain functions from development to adulthood, including neuronal migration, dendritic growth and branching and synapse formation and plasticity. Human studies have implicated Reelin signaling in several neurodevelopmental and psychiatric disorders. Mouse studies using the heterozygous Reeler (HR) mice have shown that reduced levels of Reln expression are associated with deficits in learning and memory and increased disinhibition. Although these traits are relevant to substance use disorders, the role of Reelin in cellular and behavioral responses to addictive drugs remains largely unknown. Here, we compared HR mice to wild‐type (WT) littermate controls to investigate whether Reelin signaling contributes to the hyperlocomotor and rewarding effects of cocaine. After a single or repeated cocaine injections, HR mice showed enhanced cocaine‐induced locomotor activity compared with WT controls. This effect persisted after withdrawal. In contrast, Reelin deficiency did not induce cocaine sensitization, and did not affect the rewarding effects of cocaine measured in the conditioned place preference assay. The elevated cocaine‐induced hyperlocomotion in HR mice was associated with increased protein Fos expression in the dorsal medial striatum (DMS) compared with WT. Lastly, we performed an RNA fluorescent in situ hybridization experiment and found that Reln was highly co‐expressed with the Drd1 gene, which encodes for the dopamine receptor D1, in the DMS. These findings show that Reelin signaling contributes to the locomotor effects of cocaine and improve our understanding of the neurobiological mechanisms underlying the cellular and behavioral effects of cocaine.

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