Sex differences in bladder cancer pathology and survival: analysis of a population‐based cancer registry

Zaitsu, Masayoshi; Toyokawa, Satoshi; Tonooka, Akiko; Nakamura, Fumiaki; Takeuchi, Takumi; Homma, Yukio; Kobayashi, Yasuki

doi:10.1002/cam4.379

Cited by 34 publications

(43 citation statements)

References 30 publications

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“…In the present study, the 5‐year relative survival was 80.3% for men and 67.7% for women. The survival of non‐UC patients was worse than that of UC patients, as previously reported . In either all non‐UC cases or all UC cases, relative survival of women was worse than that of men.…”

Section: Discussionsupporting

confidence: 81%

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Impact of sex difference on survival of bladder cancer: A population‐based registry data in Japan

et al. 2019

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Objective To investigate the impact of sex on the prognosis of bladder cancer in Japan. Methods In total, 18 728 patients diagnosed as having bladder cancer from 1993 to 2006 were registered in population‐based cancer registries of six prefectures in Japan. We estimated relative survival by sex, age, clinical stage at initial diagnosis and pathology. Results Patients included 14 203 men (75.8%) and 4525 women (24.2%). The stage at initial diagnosis in women was significantly higher than in men (P < 0.0001). Pathologically, women were more likely to have non‐urothelial cancer than men (women 18.0%, men 9.5%, P < 0.0001). The 5‐year relative survival was 80.3% for men and 67.7% for women. The 5‐year relative survival was 93.0% for men and 87.7% for women in the localized cancer group, 34.8% for men and 23.9% for women in the locally advanced cancer group, and 7.1% for men and 8.3% for women in the metastatic cancer group. The relative survival of women was worse than that of men in the localized cancer group (hazard ratio 1.29, 95% confidence interval 1.05–1.57; P = 0.0145) and locally advanced cancer group (hazard ratio 1.32, 95% confidence interval 1.15–1.52; P = 0.0001), but not different in the metastatic cancer group (hazard ratio 1.04, 95% confidence interval 0.87–1.25; P = 0.6555). Conclusions Population‐based registry data in Japan show that the cancer stage at initial diagnosis is higher in women than in men, and women with localized or locally advanced bladder cancer have a worse prognosis compared with men.

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Section: Discussionsupporting

confidence: 81%

“…Zaitsu et al . reported that the proportion of non‐UC in women was 8.2% and 4.0% in men . Puente et al .…”

Section: Discussionmentioning

confidence: 98%

Impact of sex difference on survival of bladder cancer: A population‐based registry data in Japan

et al. 2019

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“…A large, population‐based data set (2004‐2016) of Kanagawa Cancer Registry (KCR), a survey of over nine million people in Kanagawa prefecture that covers approximately 7% of the Japanese population, was used for analysis. Details of the study database have been previously described elsewhere . Briefly, Kanagawa Prefecture, a metropolitan prefecture located next to Tokyo, is the second largest prefecture in Japan, and KCR is one of the largest local cancer registries in Japan.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, clinicopathological variables were included in survival analyses as potential mediating variables, ie, these variables do not confound the association between sex and RCC survival, but rather, they may help to explain the observed differences. Our clinicopathological variables of interest included the following: WHO pathological grade (grades 3 or 4 [high‐grade] vs grades 1 or 2 [low‐grade]), the Union for International Cancer Control TNM stage (stages III and IV [late stage] vs stages I and II [early stage]), and any performed surgeries including radical/partial nephrectomy (yes/no), as well as SES (high SES [with the longest‐held occupational class of managerial or professional workers] vs low SES) and smoking habits (never/ever).…”

Section: Methodsmentioning

confidence: 99%

Sex‐specific analysis of renal cell carcinoma histology and survival in Japan: A population‐based study 2004 to 2016

Zaitsu

Toyokawa

Takeuchi

et al. 2019

Health Science Reports

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Background and aims In Western countries, sex differences in renal cell carcinoma (RCC) histology and survival have been previously described: compared with men, clear cell subtype is more common but overall prognosis is better among women. The goal of the present study was to examine sex differences in RCC histology and survival in Japan, using a large‐scale population‐based data set. Methods With the use of a population‐based cancer registry in Japan (2004‐2016), patients with primary RCC were followed for 5 years (median follow‐up time 2.1 years). We distinguished histological subtypes of clear cell, papillary, and chromophobe from “others” subtype. Sex‐specific prevalence ratio (PR) for each histological subtype was estimated by Poisson regression with robust variance, adjusted for age and year of diagnosis. Sex‐specific survival rates were estimated by Cox proportional hazard regression, adjusted for age, year of diagnosis, histological subtypes, and other prognostic variables, with multiple imputation. Results The prevalence of clear cell and “others” subtypes was similar between men and women among all the 5265 study subjects during the 12 years of study (clear cell, male 88.6% vs female 87.1%; “others“, male 5.3% vs female 5.3%). However, papillary subtype was less common among women than men (male 4.6% vs female 2.8%; PR = 0.63; 95% CI, 0.45‐0.88), while chromophobe subtype was more common among women (male 1.6% vs female 4.8%; PR = 3.18; 95% CI, 2.26‐4.47). Although “others” subtype (but not papillary/chromophobe subtypes) independently predicted prognosis (HR = 1.74; 95% CI, 1.32‐2.30), no sex differences were observed in RCC survival. Conclusion We did not observe a statistically significant difference in the prevalence of clear cell subtype between men and women in Japan, which differs from the pattern previously described in Western countries. Sex differences in RCC histology may not affect RCC survival in this population.

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“…Urothelial carcinoma in ICD-O-3 was defined in accordance with our previous study (Zaitsu et al 2015). Controls were patients with no history of the following tobacco-or alcohol-related diseases: all cancers (C00 to 97 in ICD-10, 140 to 208 in ICD-9), all cardiovascular diseases (I01 to I99 in ICD-10, 390 to 459 in ICD-9), all respiratory diseases (J00 to 99 in ICD-10, 460 to 519 in ICD-9), and all digestive diseases (K00 to K93 in ICD-10, 520 to 579 in ICD-9) (Katanoda et al 2008;Samanic et al 2008).…”

Section: Methodsmentioning

confidence: 99%

Risk of Alcohol Consumption in Bladder Cancer: Case-Control Study from a Nationwide Inpatient Database in Japan

Zaitsu

Nakamura

Toyokawa

et al. 2016

Tohoku J. Exp. Med.

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Bladder cancer is common in Western countries, but not in Japan. Established risk factors are smoking and high-risk jobs such as printing and manufacturing. The risk of alcohol consumption in bladder cancer has been the recent focus; however, available literature on alcohol consumption and bladder cancer has been limited from Japanese population, thought to have a weak genetic tolerance to acetaldehyde. We aimed to determine whether alcohol consumption is an independent risk factor for bladder cancer among Japanese. The study was a matched case-control study from the nationwide Japanese clinical database administered by the Rosai Hospital group. We identified 739 cases of bladder cancer diagnosed between 2005 (when the database was established) and 2014 and 7,196 controls matched by sex, age, hospital, and admission period. We estimated the odds ratio of alcohol consumption for bladder cancer adjusted for the amount of smoking, high-risk occupations, and comorbidities (hypertension, hyperlipidemia, diabetes, hyperuricemia, and obesity) with conditional logistic regression. The risk of bladder cancer was significantly higher in ever drinkers than in never drinkers (odds ratio, 1.33; 95% confidence interval, 1.06 to 1.66). Furthermore, the risk threshold for alcohol consumption was more than 15 g of alcohol intake per day (one, 180-mL cup equivalent to 6 ounces of Japanese sake containing 23 grams of alcohol). Among Japanese, alcohol consumption may be an independent risk factor for bladder cancer, with a lower risk threshold.

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Sex differences in bladder cancer pathology and survival: analysis of a population‐based cancer registry

Cited by 34 publications

References 30 publications

Impact of sex difference on survival of bladder cancer: A population‐based registry data in Japan

Impact of sex difference on survival of bladder cancer: A population‐based registry data in Japan

Sex‐specific analysis of renal cell carcinoma histology and survival in Japan: A population‐based study 2004 to 2016

Risk of Alcohol Consumption in Bladder Cancer: Case-Control Study from a Nationwide Inpatient Database in Japan

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