Sex differences in factors associated with quality of life in patients with epilepsy in Northeast China

Zhong, Rui; Lu, Yingxue; Chen, Qingling; Li, Mengmeng; Zhao, Qian; Zhang, Xinyue; Lin, Weihong

doi:10.1016/j.yebeh.2021.108076

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…Social isolation has been reported to be related to poor physical health and psychiatric conditions such as depressive symptoms (11)(12)(13). Psychiatric disorders have been identified as the most common comorbidities and one of the most important determinants of poor quality of life in patients with epilepsy (PWE) (14). Thus, social isolation may be associated with poor quality of life in PWE.…”

Section: Introductionmentioning

confidence: 99%

Social Isolation and Associated Factors in Chinese Adults With Epilepsy: A Cross-Sectional Study

et al. 2022

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Objective: We aimed to determine the prevalence of social isolation and associated factors among adults with epilepsy in northeast China.Methods: A cohort of consecutive patients with epilepsy (PWE) from the First Hospital of Jilin University (Changchun, China) was recruited. Demographic and clinical data for each patient were collected during a face-to-face interview. Social isolation was measured using the Berkman-Syme Social Network Index (SNI), and the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Quality of Life in Epilepsy Inventory (QOLIE-31) were also administered. Multivariate logistic regression analyses were used to determine the factors associated with social isolation in PWE.Results: A total of 165 patients were included in the final analysis. The mean SNI score was 2.56 (SD: 1.19), and 35 patients (21.2%) were socially isolated. In multivariate logistic regression analysis, higher depressive symptom levels (OR = 1.15, 95% CI: 1.003–1.318, P = 0.045) and poorer quality of life (OR = 0.967, 95% CI: 0.935–0.999, P = 0.047) emerged as independent factors associated with social isolation in PWE.Conclusion: Social isolation is common and occurs in approximately one-fifth of PWE. Social isolation is significantly associated with depressive symptoms and poor quality of life in PWE. Patients need to be encouraged to actively integrate with others and reduce social isolation, which may help improve their quality of life.

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Section: Introductionmentioning

confidence: 99%

Social Isolation and Associated Factors in Chinese Adults With Epilepsy: A Cross-Sectional Study

et al. 2022

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“…Insomnia is positively correlated with depression symptoms [ 18 ]. Furthermore, depression has been identified as the most important predictor of poor QOL in PWE [ 19 , 20 ]. Thus, we speculate that insomnia would increase the levels of depression symptoms, which in turn would reduce QOL.…”

Section: Introductionmentioning

confidence: 99%

“…Anxiety and depression are highly comorbid in PWE [ 24 ]. High levels of anxiety symptoms are also a strong predictive factor of poor QOL [ 20 ]. Thus, we hypothesize that anxiety symptom levels would interact with depression symptom levels to influence the relationship between insomnia and QOL in patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

Zhong

Chen

et al. 2022

BMC Psychiatry

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Objectives The association between insomnia and quality of life (QOL) in epilepsy is poorly understood and may involve interactive variables. We aimed to investigate whether and how insomnia, levels of depression and anxiety symptoms interact to influence QOL in people with epilepsy (PWE). Methods A consecutive cohort of 179 PWE was enrolled. We collected data on insomnia, levels of depression and anxiety symptoms, and QOL. The Insomnia Severity Index (ISI), Depression Inventory for Epilepsy (NDDI-E), Generalized Anxiety Disorder-7 (GAD-7), and QOL in Epilepsy Inventory (QOLIE-31) were used. The direct, indirect, and total effects of insomnia on QOL were estimated based on a moderated mediation model. Results Depression symptom levels mediated the association between insomnia and QOL (B = 0.09 SE = 0.03, p = 0.01). Depression symptom levels accounted for 34.7% of the total effect of insomnia on QOL. The mediating effect of depression symptom levels was positively moderated by anxiety symptom levels (B = 0.09, SE = 0.03, p = 0.01). Conclusion The effect of insomnia on QOL can be partially explained by the mediation of depression symptom levels. Additionally, improving anxiety symptoms may attenuate the indirect effect of insomnia on QOL through depression symptom levels.

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“…Among various populations, a total of 5-52.1% of PWE reported anxiety (14). Anxiety has been identified as a risk factor for poor quality of life, suicide risk, and poor seizure control in patients (15)(16)(17)(18). It is of vital importance to identify the risk factors contributing to anxiety symptoms to improve preventive strategies.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Comorbid Anxiety Symptoms After a New Diagnosis of Epilepsy: A Prospective 12-Month Follow-Up Observation

et al. 2021

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Objectives: We aimed to identify the factors contributing to comorbid anxiety symptoms over a 12-month follow-up period in Chinese adults with newly diagnosed epilepsy.Methods: Adult patients with newly diagnosed epilepsy (PWNDE) were recruited from First Hospital, Jilin University. Anxiety symptoms were assessed using the Generalized Anxiety Disorder-7 questionnaire (GAD-7; Chinese version) at 12 months. Multivariate stepwise logistic regression analysis was employed to identify the predictors for anxiety symptoms at 12 months.Results: A total of 157 PWNDE completed the study and were included in the final analysis. The percentage of participants with anxiety symptoms significantly decreased from 31.2% at baseline to 23.6% at 12 months (p = 0.027). Multivariate stepwise logistic regression analysis indicated that depressive symptoms at baseline [odds ratio (OR) 3.877 (95% confidence interval (CI) 1.683–8.933); P = 0.001] and the number of antiseizure medications (ASMs) during the follow-up period [OR 2.814 (95% CI 1.365–5.803); P = 0.005] were independent factors contributing to comorbid anxiety symptoms at 12 months.Conclusion: Depressive symptoms at baseline and the number of ASMs during the follow-up period were significant predictors of comorbid anxiety symptoms 12 months after a diagnosis of epilepsy.

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Sex differences in factors associated with quality of life in patients with epilepsy in Northeast China

Cited by 6 publications

References 42 publications

Social Isolation and Associated Factors in Chinese Adults With Epilepsy: A Cross-Sectional Study

Social Isolation and Associated Factors in Chinese Adults With Epilepsy: A Cross-Sectional Study

Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

Predictors of Comorbid Anxiety Symptoms After a New Diagnosis of Epilepsy: A Prospective 12-Month Follow-Up Observation

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