Sex differences in hippocampal-dependent memory and the hippocampal lipidome in adolescent rats raised on diets with or without DHA

Lamontagne-Kam, Daniel; Davari, Saeideh; Aristizabal‐Henao, Juan J.; Cho, Seungjae; Chalil, Dan; Mielke, John G.

doi:10.1016/j.plefa.2023.102569

Cited by 1 publication

(1 citation statement)

References 79 publications

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“…On the contrary, VLC n-3 PUFA dietary supplementation can improve cognitive processes. Thus, it has been demonstrated that a PUFA-enriched diet improves memory deficit in rats [69,79], DHA markedly improves spatial memory in female Sprague-Dawley rats [80], and DPA attenuates age-related deficits in spatial learning and long-term potentiation in aged rats [70].…”

Section: Effect Of Vlc N-3 Pufas On Cognitive and Behavioral Levelmentioning

confidence: 99%

The Effect of Very-Long-Chain n-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data

et al. 2023

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Alcohol use poses a significant global health concern, leading to serious physical and socioeconomic issues worldwide. The current treatment options for problematic alcohol consumption are limited, leading to the exploration of alternative approaches, such as nutraceuticals. One promising target is very-long-chain n-3 polyunsaturated fatty acids (VLC n-3 PUFAs). This review aims to compile the most relevant pre-clinical and clinical evidence on the effect of VLC n-3 PUFAs on alcohol use disorders and related outcomes. The findings suggest that VLC n-3 PUFAs may alleviate the physiological changes induced by alcohol consumption, including neuroinflammation and neurotransmitter dysregulation. Additionally, they can reduce withdrawal symptoms, improve mood, and reduce stress level, all of which are closely associated with problematic alcohol consumption. However, more research is required to fully understand the precise mechanisms by which VLC n-3 PUFAs exert their function. Furthermore, PUFAs should not be considered a standalone solution, but as a complement to other therapeutic approaches. Although preliminary evidence supports the potential therapeutic effect of VLC n-3 PUFAs on problematic alcohol consumption, additional research is needed to validate these findings and determine the optimal use of PUFAs as part of a comprehensive approach to the treatment of alcohol use disorders.

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Section: Effect Of Vlc N-3 Pufas On Cognitive and Behavioral Levelmentioning

confidence: 99%

The Effect of Very-Long-Chain n-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data

et al. 2023

View full text Add to dashboard Cite

show abstract

Sex differences in hippocampal-dependent memory and the hippocampal lipidome in adolescent rats raised on diets with or without DHA

Cited by 1 publication

References 79 publications

The Effect of Very-Long-Chain n-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data

The Effect of Very-Long-Chain n-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data

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