Sex differences in psychiatric disorders and their implication for dementia

Biskup, Ewelina; Jordan, Valeria; Nasta, Beatrice; Rauen, Katrin

doi:10.1016/b978-0-12-819344-0.00005-3

Cited by 1 publication

(1 citation statement)

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“…Late‐life depressive symptoms and all‐cause dementia are public health concerns that are frequently comorbid and disproportionately impact women. 1 , 2 The interrelationship between depressive symptoms and clinical dementia onset in later life is inconclusive, and complex, with heterogeneous patterns. 3 , 4 Depressive episodes may be a causal factor exerting a neurotoxic effect on the brain, thereby increasing dementia risk.…”

Section: Introductionmentioning

confidence: 99%

20‐year depressive symptoms, dementia, and structural neuropathology in older women

Petkus,

Wang,

Younan

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONThe course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.METHODSUtilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In a subsample of 569 women who underwent structural magnetic resonance imaging, we examined whether estimates of cerebrovascular disease and Alzheimer's disease (AD)‐related neurodegeneration were associated with identified trajectories.RESULTSFive trajectories of depressive symptoms and dementia risk were identified. Compared to women with minimal symptoms, women who reported mild and stable and emerging depressive symptoms were at the highest risk of developing dementia and had more cerebrovascular disease and AD‐related neurodegeneration.DISCUSSIONThere are heterogeneous profiles of depressive symptoms and dementia risk. Common neuropathological factors may contribute to both depression and dementia.Highlights The progression of depressive symptoms and concurrent dementia risk is heterogeneous. Emerging depressive symptoms may be a prodromal symptom of dementia. Cerebrovascular disease and AD are potentially shared neuropathological factors.

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