Sex Differences in Risk Factors for Cardiovascular Disease: The PERU MIGRANT Study

Bernabé‐Ortiz, Antonio; Benziger, Catherine P.; Gilman, Robert H.; Smeeth, Liam; Miranda, J. Jaime

doi:10.1371/journal.pone.0035127

Cited by 26 publications

(25 citation statements)

References 32 publications

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“…From the 172 articles, 73 were excluded for being duplicates and the remaining 99 were examined in full-text. Of these, 82 were discarded because they did not meet the selection criteria, resulting in a total of 17 articles for data extraction [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 summarizes the main features of the 17 included articles. Four articles 19,20,23,34 were published in 3 Peruvians journals and 13 21,22,[24][25][26][27][28][29][30][31][32][33]35 in 11 foreign journals. Of the total, 3 reported belonging to the ENINBSC study 36 , 3 to the PERU MIGRANT study 37 , 2 to the CARMELA study 33 , 2 to the PREVENCION study 38 , 2 to the PIRS study and 1 to the FRENT study.…”

Section: Resultsmentioning

confidence: 99%

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Las deficiencias en la presentación de los estudios transversales de acuerdo con la declaración STROBE: el caso del síndrome metabólico en adultos de Perú

et al. 2015

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Introduction: The inadequate reporting of cross-sectional studies, as in the case of the prevalence of metabolic syndrome, could cause problems in the synthesis of new evidence and lead to errors in the formulation of public policies. Objective: To evaluate the reporting quality of the articles regarding metabolic syndrome prevalence in Peruvian adults using the STROBE recommendations. Methods: We conducted a thorough literature search with the terms "Metabolic Syndrome", "Sindrome Metabolico" and "Peru" in MEDLINE/PubMed, LILACS, SciELO, LIPECS and BVS-Peru until December 2014. We selected those who were population-based observational studies with randomized sampling that reported prevalence of metabolic syndrome in adults aged 18 or more of both sexes. Information was analysed through the STROBE score per item and recommendation. Results: Seventeen articles were included in this study. All articles met the recommendations related to the report of the study's rationale, design, and provision of summary measures. The recommendations with the lowest scores were those related to the sensitivity analysis (8%, n= 1/17), participant flowchart (18%, n= 3/17), missing data analysis (24%, n= 4/17), and number of participants in each study phase (24%, n= 4/17). Conclusion: Cross-sectional studies regarding the prevalence of metabolic syndrome in peruvian adults have an inadequate reporting on the methods and results sections. We identified a clear need to improve the quality of such studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Las deficiencias en la presentación de los estudios transversales de acuerdo con la declaración STROBE: el caso del síndrome metabólico en adultos de Perú

et al. 2015

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“…These women were physically active, which we speculate may have contributed to their largely normal pre-ART hsCRP concentrations. Although smoking rates and alcohol intake were not evaluated in our Peruvian cohort, these behaviors are more prevalent among Peruvian men [25,26]. …”

Section: Discussionmentioning

confidence: 99%

Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy

Ticona

Bull

Soria

et al. 2015

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Objective Inflammatory biomarkers associated with cardiovascular disease are elevated in HIV-infected persons. These biomarkers improve with antiretroviral therapy (ART) but do not normalize to values observed in HIV-uninfected adults. Little is known regarding biomarkers of inflammation in HIV-infected Peruvians, in whom an increased burden of infectious diseases may exacerbate inflammation, and women, in whom sex difference may alter inflammation compared with men. Methods Peruvians initiating first-line ART were enrolled in a prospective observational study. Individuals with suppression of HIV RNA plasma loads to less than 30 copies/ml when determined quarterly over 24 months of ART, had biomarkers of inflammation and cellular activation measured pre-ART and at 24-months of ART, and evaluated for associations with sex and clinical parameters. Results Pre-ART high-sensitivity C-reactive protein (hsCRP) values of men were in the high-risk cardiovascular disease category (>3.0mg/l) more frequently compared with women (P = 0.02); most women’s values were in the low/average-risk categories. At 24 months of suppressive ART, hsCRP concentrations decreased in men (P = 0.03), but tended to increase in women, such that the proportion with high-risk hsCRP did not differ by sex. Pre-ART, soluble CD163 concentrations were higher in women compared with men (P = 0.02), and remained higher after 24 months of suppressive ART (P = 0.02). All other inflammatory biomarkers (P < 0.03) decreased across sexes. Biomarker concentrations were not associated with BMI or coinfections. Conclusion Elevated inflammatory biomarkers persisted despite 24 months of suppressive ART in a subset of Peruvians, and to a greater extent in women compared with men. These findings suggest that lifestyle or pharmacologic interventions may be required to optimize the health of HIV-infected Peruvians, particularly women.

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“…El síndrome metabólico alcanzaba 12, 32 y 43% en los grupos rural, migrante y urbano (31) . Estas diferencias, en hipertensión y síndrome metabólico, fueron notorias también según sexo en el grupo de migrantes (33) .…”

Section: Estudios Sobre Migración Rural-urbana En El Perúunclassified

Transiciones en contexto: hallazgos vinculados a migración rural-urbana y enfermedades no transmisibles en Perú

Miranda¹,

Wells²,

Smeeth³

2012

Rev Peru Med Exp Salud Publica

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Sex Differences in Risk Factors for Cardiovascular Disease: The PERU MIGRANT Study

Cited by 26 publications

References 32 publications

Las deficiencias en la presentación de los estudios transversales de acuerdo con la declaración STROBE: el caso del síndrome metabólico en adultos de Perú

Las deficiencias en la presentación de los estudios transversales de acuerdo con la declaración STROBE: el caso del síndrome metabólico en adultos de Perú

Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy

Transiciones en contexto: hallazgos vinculados a migración rural-urbana y enfermedades no transmisibles en Perú

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