Sex differences in the acute ethanol effects on object recognition memory: influence of estrous cycle

Paiva-Santos, Murilo A.; Leão, Anderson H.F.F.; Kurita, João P.F.; Becegato, Marcela; Lima, Alvaro C.; Bioni, Vinícius S.; Meurer, Ywlliane da Silva Rodrigues; Cunha, Débora M.G.; Medeiros, André M.; Silva, Regina H.

doi:10.1097/fbp.0000000000000680

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Although no prior studies have examined the effect of CIH on recollective memory in females, studies have examined sex differences in recollective memory in response to neurotoxins. These findings on sex differences in recollective memory were equivocal, in which some studies show no sex differences in recollective memory impairment [ 130 , 131 ] or only males were impaired and not females [ 130 , 132 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea

Mabry,

Bradshaw,

Gardner

et al. 2024

Biol Sex Differ

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Background Obstructive sleep apnea (OSA) affects 10–26% of adults in the United States with known sex differences in prevalence and severity. OSA is characterized by elevated inflammation, oxidative stress (OS), and cognitive dysfunction. However, there is a paucity of data regarding the role of sex in the OSA phenotype. Prior findings suggest women exhibit different OSA phenotypes than men, which could result in under-reported OSA prevalence in women. To examine the relationship between OSA and sex, we used chronic intermittent hypoxia (CIH) to model OSA in rats. We hypothesized that CIH would produce sex-dependent phenotypes of inflammation, OS, and cognitive dysfunction, and these sex differences would be dependent on mitochondrial oxidative stress (mtOS). Methods Adult male and female Sprague Dawley rats were exposed to CIH or normoxia for 14 days to examine the impact of sex on CIH-associated circulating inflammation (IL-1β, IL-6, IL-10, TNF-α), circulating steroid hormones, circulating OS, and behavior (recollective and spatial memory; gross and fine motor function; anxiety-like behaviors; and compulsive behaviors). Rats were implanted with osmotic minipumps containing either a mitochondria-targeting antioxidant (MitoTEMPOL) or saline vehicle 1 week prior to CIH initiation to examine how inhibiting mtOS would affect the CIH phenotype. Results Sex-specific differences in CIH-induced inflammation, OS, motor function, and compulsive behavior were observed. In female rats, CIH increased inflammation (plasma IL-6 and IL-6/IL-10 ratio) and impaired fine motor function. Conversely, CIH elevated circulating OS and compulsivity in males. These sex-dependent effects of CIH were blocked by inhibiting mtOS. Interestingly, CIH impaired recollective memory in both sexes but these effects were not mediated by mtOS. No effects of CIH were observed on spatial memory, gross motor function, or anxiety-like behavior, regardless of sex. Conclusions Our results indicate that the impact of CIH is dependent on sex, such as an inflammatory response and OS response in females and males, respectively, that are mediated by mtOS. Interestingly, there was no effect of sex or mtOS in CIH-induced impairment of recollective memory. These results indicate that mtOS is involved in the sex differences observed in CIH, but a different mechanism underlies CIH-induced memory impairments.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea

Mabry,

Bradshaw,

Gardner

et al. 2024

Biol Sex Differ

View full text Add to dashboard Cite

show abstract

“…Although no prior studies have examined the effect of CIH on recollective memory in females, studies have examined sex differences in recollective memory in response to neurotoxins. These ndings on sex differences in recollective memory were equivocal, in which some studies show no sex differences in recollective memory impairment [107,108] or only males were impaired and not females [107,109].…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent effects of chronic intermittent hypoxia: Implication for obstructive sleep apnea

Mabry,

Bradshaw,

Gardner

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Obstructive sleep apnea (OSA) affects 10–26% of adults in the United States with known sex differences in prevalence and severity. OSA is characterized by elevated inflammation, oxidative stress (OS), and cognitive dysfunction. However, there is a paucity of data regarding the role of sex in the OSA phenotype. Prior findings suggest women exhibit different OSA phenotypes than men, which could result in under-reported OSA prevalence in women. To examine the relationship between OSA and sex, we used chronic intermittent hypoxia (CIH) to model OSA in rats. We hypothesized that CIH would produce sex-dependent phenotypes of inflammation, OS, and cognitive dysfunction, and these sex differences would be dependent on mitochondrial oxidative stress (mtOS). Methods Adult male and female Sprague Dawley rats were exposed to CIH or normoxia for 14 days to examine the impact of sex on CIH-associated circulating inflammation (IL-1β, IL-4, IL-6, IL-10, TNF-α), circulating OS, and behavior (recollective and spatial memory; gross and fine motor function; anxiety-like behaviors; and compulsive behaviors). A subset of rats was implanted with osmotic minipumps containing either a mitochondria-targeting antioxidant (MitoTEMPOL) or saline vehicle 1 week prior to CIH initiation to examine how inhibiting mtOS would affect the CIH phenotype. Results Sex-specific differences in CIH-induced inflammation, OS, motor function, and compulsive behavior were observed. In female rats, CIH increased inflammation (plasma IL-6 and IL-6/IL-10 ratio) and impaired fine motor function. Conversely, CIH elevated circulating OS and compulsivity in males. These sex-dependent effects of CIH were blocked by inhibiting mtOS. Interestingly, CIH impaired recollective memory in both sexes but these effects were not mediated by mtOS. No effects of CIH were observed on spatial memory, gross motor function, or anxiety-like behavior, regardless of sex. Conclusions Our results indicate that the impact of CIH is dependent on sex, such as an inflammatory response and OS response in females and males, respectively, that are mediated by mtOS. Interestingly, there was no effect of sex or mtOS in CIH-induced impairment of recollective memory. These results indicate that mtOS is involved in the sex differences observed in CIH, but a different mechanism underlies CIH-induced memory impairments.

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Alcohol induces apoptosis and autophagy in microglia BV-2 cells

Wang

Song

Coronado

et al. 2023

Food and Chemical Toxicology

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Sex differences in the acute ethanol effects on object recognition memory: influence of estrous cycle

Cited by 3 publications

References 67 publications

Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea

Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea

Sex-dependent effects of chronic intermittent hypoxia: Implication for obstructive sleep apnea

Alcohol induces apoptosis and autophagy in microglia BV-2 cells

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