Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder

Dong, Rui; Haque, Anam; Wu, Hanjing Emily; Placide, John; Yu, Liling; Zhang, Xiang Yang

doi:10.1016/j.jad.2021.05.110

Cited by 21 publications

(15 citation statements)

References 69 publications

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“…Therefore, abnormal glucose metabolism is observed in patients with depression. Further research shows that suicide attempts in men and women were significantly related to the body's blood sugar levels (Dong et al, 2021), which is consistent with the results of this research. At present, the association between depression and glucose metabolism disorder has been widely studied and recognized, but whether the two diseases co-occur or which disease is the cause of the other remains unclear (Réus et al, 2017).…”

Section: Discussionsupporting

confidence: 91%

Circulating metabolites and depression: a bidirectional Mendelian randomization

et al. 2023

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BackgroundStudies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of circulating metabolites in depression.MethodsIn this study, the top single-nucleotide polymorphisms (SNPs) associated with circulating metabolites (n = 24,925) and depression (n = 322,580) were obtained based on the publicly available genome-wide association study using two-sample Mendelian randomization (MR). SNP estimates were summarized through inverse variance weighted, MR Egger, weighted median, MR pleiotropy residual sum and outlier, and “leave-one-out” methods.ResultsApolipoprotein A-I (OR 0.990, 95% CI 981–0.999) and glutamine (OR 0.985, 95% CI 0.972–0.997) had protective causal effects on depression, whereas acetoacetate (OR 1.021, 95% CI 1.009–1.034), glycoproteins (OR 1.005, 95% CI 1.000–1.009), isoleucine (OR 1.013, 95% CI 1.002–1.024), and urea (OR 1.020, 95% CI 1.000–1.039) had an anti-protective effect on depression. Reversed MR showed no effect of depression on the seven circulating metabolites.ConclusionIn this study, MR analysis showed that apolipoprotein A-I and glutamine had a protective effect on depression, and acetoacetate, glycoprotein, isoleucine, glucose, and urea may be risk factors for depression. Therefore, further research must be conducted to translate the findings into practice.

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Section: Discussionsupporting

confidence: 91%

Circulating metabolites and depression: a bidirectional Mendelian randomization

et al. 2023

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“…Evidence suggests that disturbances in glucose metabolism may be associated with suicidal ideation and attempts (119). A recent study has found a significant association between blood glucose and suicide attempts in male patients with MDD (120). Taken together, our findings suggest that pathways underlying vasopressin-regulated water reabsorption and the cellular hexose transport system warrant additional investigation in association with SB.…”

Section: Vasopressin Regulated Water Metabolism and Hexose Transport ...supporting

confidence: 61%

Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population

Peng

Gilder

Bernert

et al. 2023

Preprint

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American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and alcohol use disorders (AUD) among all ethnic groups in the US. Rates of suicide and AUD vary substantially between tribal groups and across different geographical regions, underscoring a need to delineate more specific risk and resilience factors. Using data from over 740 AI living within eight contiguous reservations, we assessed genetic risk factors for SB by investigating: (1) possible genetic overlap with AUD, and (2) impacts of rare and low frequency genomic variants. Suicidal behaviors included lifetime history of suicidal thoughts and acts, including verified suicide deaths, scored using a ranking variable for the SB phenotype (range 0-4). We identified five loci significantly associated with SB and AUD, two of which are intergenic and three intronic on genes AACSP1, ANK1, and FBXO11. Nonsynonymous rare mutations in four genes including SERPINF1 (PEDF), ZNF30, CD34, and SLC5A9, and non-intronic rare mutations in genes OPRD1, HSD17B3 and one lincRNA were significantly associated with SB. One identified pathway related to hypoxia-inducible factor (HIF) regulation, whose 83 nonsynonymous rare variants on 10 genes were significantly linked to SB as well. Four additional genes, and two pathways related to vasopressin-regulated water metabolism and cellular hexose transport, also were strongly associated with SB. This study represents the first investigation of genetic factors for SB in an American Indian population that has high risk for suicide. Our study suggests that bivariate association analysis between comorbid disorders can increase statistical power; and rare variant analysis in a high-risk population enabled by whole-genome sequencing has the potential to identify novel genetic factors. Although such findings may be population specific, rare functional mutations relating to PEDF and HIF regulation align with past reports and suggest a biological mechanism for suicide risk and a potential therapeutic target for intervention.

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“…To evaluate psychotic symptoms, we adopted the positive subscale of the Positive and Negative Syndrome Scale (PANSS) ( 8 , 26 ). Patients were deemed to exhibit psychotic symptoms if they had a positive subscale score of 15 or above ( 27 , 28 ).…”

Section: Methodsmentioning

confidence: 99%

Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences

et al. 2023

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BackgroundLipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naïve (FEDN) MDD patients with dysglycemia were examined according to sex.MethodsOne thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected.ResultsThe prevalence of abnormal lipid metabolism in both male and female MDD patients with abnormal glucose metabolism was higher than that in patients without abnormal glucose metabolism. Among male MDD patients with abnormal glucose metabolism, TC was positively correlated with HAMD score, TSH and TgAb levels, but negatively correlated with PANSS positive subscale scores. LDL-C was positively correlated with TSH and BMI, but negatively correlated with PANSS positive subscale scores. HDL-C was negatively correlated with TSH levels. Among females, TC was positively correlated with HAMD score, TSH, and BMI, but negatively correlated with PANSS positive subscale score. LDL-C was positively correlated with HADM score and negatively correlated with FT3 level. HDL-C was negatively correlated with TSH and BMI levels.ConclusionThere are sex differences in the correlated factors of lipid markers in MDD patients with impaired glucose.

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Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder

Cited by 21 publications

References 69 publications

Circulating metabolites and depression: a bidirectional Mendelian randomization

Circulating metabolites and depression: a bidirectional Mendelian randomization

Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population

Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences

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