Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia

Yang, Yating; Wang, Juan; Ning, Xiaoshuai; Zhang, Yelei; Zhao, Tuanjie; Zhong, Yi; Liu, Zhiwei; Xia, Lei; Li, Wenzheng; Yao, Xianhu; Zhang, Kai; Liu, Huanzhong

doi:10.3389/fpsyt.2021.656230

Cited by 7 publications

(6 citation statements)

References 73 publications

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“…Previous literature indicated that insulin levels were increased in schizophrenic patients compared to the healthy population ( 48 , 49 ) and were positively related to leptin levels in the early course of the illness ( 31 ). During the treatment of schizophrenia, leptin levels and insulin levels were also positively correlated ( 37 , 50 ).…”

Section: Discussionmentioning

confidence: 98%

Association of higher plasma leptin levels with HOMA-IR index, high sensitivity C-reactive protein and glycolipid metabolism in patients with chronic schizophrenia: A multi-center cross-sectional study

Liu¹,

Wang

Xia

et al. 2022

Front. Psychiatry

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BackgroundPrevious research has revealed that plasma leptin levels were closely related to glycolipid metabolism in schizophrenic patients. Insulin resistance (IR) and high sensitivity C-reactive protein (hs-CRP) were involved in glucolipid metabolism disorders. This study explored the correlation between plasma higher leptin levels, homeostasis model assessment of insulin resistance (HOMA-IR) index, hs-CRP and glycolipid metabolism in patients with chronic schizophrenia (CS).Methods322 subjects were enrolled, and the psychopathological symptoms of each patient were assessed by a 30-item Positive and Negative Syndrome Scale (PANSS−30). Patients' plasma leptin levels were measured by enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose (FBG) levels were determined by oxidase method. Insulin levels were tested by electrochemiluminescence, and hs-CRP levels were tested by immunoturbidimetry. IBM SPSS 22.0 was used for data analysis.ResultsCompared to the lower leptin group, patients in the higher leptin group had significantly higher body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), insulin, HOMA-IR and hs-CRP levels; and lower negative factor scores, cognitive factor scores, and PANSS total scores (P < 0.05). Plasma leptin levels in CS patients were positively correlated with BMI, TC, TG, LDL-C, insulin, HOMA-IR and hs-CRP levels, and were negatively correlated with gender (male = 1, Female = 2), positive factor scores, negative factor scores, cognitive factor scores and PANSS total scores. Multiple linear regression analysis revealed that gender, BMI, positive factor scores, PANSS total scores, FBG, LDL-C, insulin, HOMA-IR and hs-CRP levels were independent influencing factors of leptin levels in CS patients (P < 0.05).ConclusionGender, BMI, positive factor scores, PANSS total scores, FBG, LDL-C, insulin, HOMA-IR and hs-CRP levels were independent influencing factors of plasma leptin levels in CS patients. Plasma leptin, HOMA-IR and hs-CRP levels should be measured regularly in CS patients to prevent or treat the disorders of glucose and lipid metabolism comorbidity with schizophrenia patients in clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 98%

Association of higher plasma leptin levels with HOMA-IR index, high sensitivity C-reactive protein and glycolipid metabolism in patients with chronic schizophrenia: A multi-center cross-sectional study

Liu¹,

Wang

Xia

et al. 2022

Front. Psychiatry

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“…E.g., in one study, BDNF levels were shown to be negatively correlated with body mass index (BMI) gain in female patients but not in male patients (133). This was supported by another study, showing that decreased BDNF serum levels were associated with weight gain in female schizophrenia patients receiving long-term antipsychotic treatment (134). In this study, in 332 patients suffering from chronic schizophrenia treated with APDs, homeostatic model assessment for insulin resistance (HOMA-IR) and BDNF are associated in a differential manner according to.…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 89%

“…In this study, in 332 patients suffering from chronic schizophrenia treated with APDs, homeostatic model assessment for insulin resistance (HOMA-IR) and BDNF are associated in a differential manner according to. Hence, it is important to consider gender when measuring BDNF levels in patients with schizophrenia and metabolic indicators ( 134 ).…”

Section: Effector Molecules In Apd-induced Appetite and Weight Gainmentioning

confidence: 99%

Understanding the Effects of Antipsychotics on Appetite Control

et al. 2022

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Antipsychotic drugs (APDs) represent a cornerstone in the treatment of schizophrenia and other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so-called extrapyramidal side effects, and they have gradually been replaced by second (atypical) and third-generation APDs, with less extrapyramidal side effects and, in some cases, improved efficacy. However, the use of many of the current APDs has been limited due to their propensity to stimulate appetite, weight gain, and increased risk for developing type 2 diabetes and cardiovascular disease in this patient group. The mechanisms behind the appetite-stimulating effects of the various APDs are not fully elucidated, partly because their diverse receptor binding profiles may affect different downstream pathways. It is critical to identify the molecular mechanisms underlying drug-induced hyperphagia, both because this may lead to the development of new APDs, with lower appetite-stimulating effects but also because such insight may provide new knowledge about appetite regulation in general. Hence, in this review, we discuss the receptor binding profile of various APDs in relation to the potential mechanisms by which they affect appetite.

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“…Several surrogate estimates have been proposed for assessing insulin sensitivity, including HOMA-IR, HOMA-β, and QUICKI [ 20 , 21 ]. However, the threshold of HOMA-IR for evaluating insulin resistance has not been unified because of various associated factors of HOMA-IR, including age, sex, race, and weight [ 22 , 23 , 24 ]. HOMA-IR is strongly correlated with body weight as there is a significant difference in HOMA-IR between normal weight and obese individuals [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, HOMA-IR may be affected by race, and the participants of these previous studies were all Caucasians [ 23 ]. Several published studies have investigated HOMA-IR in Asian populations and determined the average HOMA-IR in healthy males and females [ 22 , 30 , 31 ]. To date, there is no study focused on the relationship between HOMA-IR and body weight in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values

Duo

Song

Zhang

et al. 2022

JPM

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Objective: To investigate the ability of homeostasis model assessment of insulin resistance (HOMA-IR) in early pregnancy for predicting gestational diabetes mellitus (GDM) in Chinese women with different first-trimester body mass index (FT-BMI) values. Methods: Baseline characteristics and laboratory tests were collected at the first prenatal visit (6–12 weeks of gestation). GDM was diagnosed by a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation. Partial correlation analysis and binary logistic regression were applied to identify the association between HOMA-IR and GDM. The cutoff points for predicting GDM were estimated using receiver operating characteristic (ROC) curve analysis. Results: Of the total of 1343 women, 300 (22.34%) were diagnosed with GDM in the 24–28 weeks of gestation. Partial correlation analysis and binary logistic regression verified HOMA-IR as a significant risk factor for GDM in the normal weight subgroup (FT-BMI < 24 kg/m2) (adjusted OR 2.941 [95% CI 2.153, 4.016], P < 0.001), overweight subgroup (24.0 kg/m2 ≤ FT-BMI < 28.0 kg/m2) (adjusted OR 3.188 [95% CI 2.011, 5.055], P < 0.001), and obese subgroup (FT-BMI ≥ 28.0 kg/m2) (adjusted OR 9.415 [95% CI 1.712, 51.770], p = 0.01). The cutoff values of HOMA-IR were 1.52 (area under the curve (AUC) 0.733, 95% CI 0.701–0.765, p < 0.001) for all participants, 1.43 (AUC 0.691, 95% CI 0.651–0.730, p < 0.001) for normal weight women, 2.27 (AUC 0.760, 95% CI 0.703–0.818, p < 0.001) for overweight women, and 2.31 (AUC 0.801, 95% CI 0.696–0.907, p < 0.001) for obese women. Conclusions: Increased HOMA-IR in early pregnancy is a risk factor for GDM, and HOMA-IR can be affected by body weight. The cutoff value of HOMA-IR to predict GDM should be distinguished by different FT-BMI values.

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Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia

Cited by 7 publications

References 73 publications

Association of higher plasma leptin levels with HOMA-IR index, high sensitivity C-reactive protein and glycolipid metabolism in patients with chronic schizophrenia: A multi-center cross-sectional study

Association of higher plasma leptin levels with HOMA-IR index, high sensitivity C-reactive protein and glycolipid metabolism in patients with chronic schizophrenia: A multi-center cross-sectional study

Understanding the Effects of Antipsychotics on Appetite Control

Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values

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