Sex differences in the relationship among alcohol, smoking, and <i>Helicobacter pylori</i> infection in asymptomatic individuals

Wu, Wenzhi; Leja, Mārcis; Цуканов, В. В.; Basharat, Zarrin; Dong, Hua; Hong, Wandong

doi:10.1177/0300060520926036

Cited by 12 publications

(15 citation statements)

References 29 publications

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“… 16 A recent study reported that the total prevalence of H. pylori infection among asymptomatic individuals was 55.2% in Wenzhou, China. 17 In our study, the prevalence of H. pylori infection was 35.0%, which is lower than the previously reported rate of 60% in the rural areas of China. 18 , 19 Considering that China is one of the most rapidly developing countries and that the socioeconomic status of residents has been improving significantly over recent decades, especially in the Shenzhen area where socioeconomic status and income levels are high, a declining trend in the prevalence of H. pylori infection may be occurring.…”

Section: Discussioncontrasting

confidence: 82%

Sex-Specific Risk Factors Associated with Helicobacter pylori Infection Among Individuals Undergoing Health Examinations in China

Wu¹,

Zeng²,

Zhang³

et al. 2022

IJGM

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Helicobacter pylori is one of the most common causes of peptic ulcers, gastritis, and gastric cancers. This study investigated sex-specific differences in the prevalence of H. pylori infection and its associated factors among individuals undergoing hospital-based health examinations in southern China. Methods: This study enrolled consecutive healthy individuals who underwent regular health examinations at a hospital physical examination center between September 2020 and September 2021. Anthropometric characteristics and biochemical profiles were measured. All individuals underwent carbon-13 urea breath tests. Univariate and multivariate analyses were used to evaluate the factors associated with H. pylori infection. Results: A total of 5035 individuals (men, 59.1%; women, 40.9%) were included in the analyses. The total rate of H. pylori infection was 35.0% (men, 35.5%; women, 34.3%). In the multivariate analysis, the risk factors identified for H. pylori infections were high fasting blood glucose levels and blood pressure ≥160 mmHg in men and older age, high body mass index, and low albumin levels in women. Conclusion: These findings suggest that physicians must be aware of the metabolic factors associated with H. pylori infections in the Chinese population. Early detection of these factors and timely intervention are expected to reduce H. pylori infections and provide a theoretical basis for the primary prevention of several gastrointestinal diseases.

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Section: Discussioncontrasting

confidence: 82%

Sex-Specific Risk Factors Associated with Helicobacter pylori Infection Among Individuals Undergoing Health Examinations in China

Wu¹,

Zeng²,

Zhang³

et al. 2022

IJGM

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“…Additionally, age, occupation, the type of drinking water used, consumption of fruits, vegetables, or fried food are also independent risk factors for H. pylori infection [14][15][16]. Smoking and alcohol consumption were also found to be independently positively associated factors [17]. Many of these risk factors are preventable with adequate knowledge and appropriate practice.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection: Comparison of Knowledge between Health Science and Non-Health Science University Students

Hafiz

D'Sa

Zamzam

et al. 2021

IJERPH

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Background: Helicobacter pylori (H. pylori), an important human pathogen, is classified as a human carcinogen. It is known to cause dyspepsia, peptic ulcers, and gastric cancer. Awareness regarding H. pylori infections in Saudi Arabia awaits investigation to reduce or even eliminate the infection that would ease the substantial burden of managing H. pylori among both malignant and non-malignant diseases. Aims: The study aims were to (1) assess the knowledge of H. pylori infection, testing, and management among undergraduate students in Saudi Arabia and (2) compare the H. pylori knowledge among health science and non-health science students. Methods: This study involved a cross-sectional online survey among 334 undergraduate students in health science and non-health science colleges at King Saud University, Saudi Arabia, using a valid and reliable author-developed survey. The survey had two sections: the socio-demographic factors and knowledge items regarding H. pylori. Data were collected during the 2019–2020 academic year. Data analysis included descriptive statistics, Chi-square, and Mann–Whitney U test. The knowledge scores were categorized as poor, fair, and good. Results: Less than 10% of the students in both groups had a good knowledge level about H. pylori. The comparison of the overall mean between both groups was non-significant. Moreover, the level of knowledge of the respondents was significantly associated with their university level (p < 0.001), family monthly income (p < 0.007), having heard about H. pylori infection (p < 000.1), and a previous history of H. pylori infection (p < 000.1). Conclusion: The overall knowledge level of Saudi undergraduate students about H. pylori infection was low. Thus, health awareness interventions through educational programs are recommended for improving their knowledge about H. pylori infection and its prevention.

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“…Data on the association of smoking and alcohol use on H. pylori prevalence are conflicting. Wu et al found that smoking and alcohol consumption were risk factors for H. pylori infection among adult males but were protective factors for females 40 . Murray et al reported that smoking is positively associated with H. pylori infection but not alcohol consumption 31 .…”

Section: Discussionmentioning

confidence: 99%

H. pylori predictors and outcomes among adults undergoing upper endoscopy at a Jamaican teaching hospital: A cross‐sectional study

et al. 2023

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Background Recent data on the prevalence of H. pylori infection in Jamaica are lacking. It is postulated that there has been a decline in the prevalence of H. pylori infection and its associated complications. We determined sociodemographic characteristics, prevalence of H. pylori infection and clinical outcomes among adults undergoing esophagogastroduodenoscopy (EGD) and histology at the University Hospital of the West Indies (UHWI) between May 2018 and December 2020. Materials and methods A cross‐sectional study of patients (≥18 years old), who underwent EGD and histological evaluation for H. pylori infection, was conducted. Associations of H. pylori positivity and gastric cancer with sociodemographic/clinical variables and endoscopic findings were determined by stepwise logistic regression using backward selection. Unadjusted and adjusted odds ratios with related 95% confidence intervals (Cis) were calculated for H. pylori positivity and gastric cancer status. Results There were 323 participants (mean age 58.6 ± 17.8 years, 54.2% females). H. pylori prevalence was 22.2% (n = 70 of 315), 5.6% had gastric neoplasia (GN), 15.5% gastric atrophy, 11.4% intestinal metaplasia and 3.7% dysplasia on histology. Mucositis (64.5%), gastric ulcer (14.9%), and duodenal ulcer (13.9%) were the most common endoscopic findings. Participants with peptic ulcer disease (PUD) (unOR = 4.0; p = .017), gastric cancer (unOR = 9.5; p = .003), gastric atrophy (unOR = 12.8; p < .001), and intestinal metaplasia (unOR = 5.0; p < .001) had a significantly higher odds of being H. pylori positive, but after multivariable analyses only gastric atrophy remained significant (aOR = 27.3; p < .001). Participants with mucositis had a significantly lower odds of gastric cancer (unOR 0.1; p = .035) while participants with dysplasia had significantly higher odds (unOR 8.0; p = .042), but these were no longer significant after multivariable analyses (aOR = 0.2; p = .156 and aOR = 18.9; p = .070, respectively). Conclusions Histology based prevalence of H. pylori infection is lower than previously reported in Jamaica. Gastric atrophy is a significant predictor of H. pylori positivity.

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Sex differences in the relationship among alcohol, smoking, and Helicobacter pylori infection in asymptomatic individuals

Cited by 12 publications

References 29 publications

Sex-Specific Risk Factors Associated with Helicobacter pylori Infection Among Individuals Undergoing Health Examinations in China

Sex-Specific Risk Factors Associated with Helicobacter pylori Infection Among Individuals Undergoing Health Examinations in China

Helicobacter pylori Infection: Comparison of Knowledge between Health Science and Non-Health Science University Students

H. pylori predictors and outcomes among adults undergoing upper endoscopy at a Jamaican teaching hospital: A cross‐sectional study

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