Sex Hormones and Prostatic Pathology

Owen, Seward E.; Cutler, Max

doi:10.1158/ajc.1936.308

Cited by 17 publications

(2 citation statements)

References 9 publications

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“…In contrast to our findings, previous investigators (Owen and Cutler, 1936;Bulbrook et al, 1959;Jonsson et a[., 1963) found no difference in oestrogen excretion between controls or BPH patients and PC patients. This may be explained by poor matching of patients and unreliable biological or colorimetric assay methods used in these earlier series.…”

Section: Discussioncontrasting

confidence: 99%

“…Results correlating urinary excretion of oestrogens with increasing age and in prostatic diseases are rare and controversial (Owen and Cutler, 1936;Bulbrook er al., 1959;Jonsson et al, 1963;Marmorston et a/., 1965;May and Stimmel, 1965;Skoldefors et al, 1976). To our knowledge, no studies have yet been carried out using modern radioimmunological procedures, including a chromatographic step for separation of the oestrogens.…”

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confidence: 99%

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Urinary Oestrogen Excretion in Benign Prostatic Hyperplasia and Prostatic Cancer

Rannikko

Adlercreutz

Haapiainen

1989

British Journal of Urology

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Urinary oestrogen excretion was measured in 20 healthy middle-aged men (controls), in 30 patients with benign prostatic hyperplasia (BPH) and in 32 prostatic cancer (PC) patients. The mean oestradiol (E2) excretion was significantly lower in the PC patients than in the controls and BPH patients. No other significant differences were found in oestrone (E1), oestriol (E3) and total oestrogen (E1 + E2 + E3) excretion between the 3 groups. The decreased E2 excretion in the PC patients is in accordance with our previous finding concerning significantly lower E2 plasma levels in PC patients. It seems possible that elderly men with lower endogenous oestrogen levels are at higher risk of developing cancer. On the other hand, the age-dependent increased oestrogen levels may play an aetiological role in BPH.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%