Sex-Related Effects on Cardiac Development and Disease

Siokatas, Georgios; Papatheodorou, Ioanna; Daiou, Angeliki; Lazou, Antigone; Hatzistergos, Konstantinos E.; Kararigas, Georgios

doi:10.3390/jcdd9030090

Cited by 10 publications

(6 citation statements)

References 149 publications

(193 reference statements)

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“…Furthermore, using logistic regression models we show a significant association between the history of cardiac problems and the occurrence of iPD. With males being at a greater risk for CVD [ 27 ], our investigation further reveals that males with CVD history are exposed to a greater risk of iPD development than females with CVD history. The autonomic nervous system is mainly involved in controlling the heart rate.…”

Section: Discussionmentioning

confidence: 85%

Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Acharya,

Lumley,

Devaux

et al. 2024

BMC Neurosci

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Background Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.

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Section: Discussionmentioning

confidence: 85%

Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Acharya,

Lumley,

Devaux

et al. 2024

BMC Neurosci

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“…In various diseases, including CVD, there are fundamental differences between the sexes in manifestation and outcome, as well as the response to treatment [ 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Overall, sex differences are generally attributed to genetic and epigenetic mechanisms, regulating major biological processes, including cell death, extracellular matrix deposition and inflammation, as well as sex hormones and their receptors [ 77 , 82 , 83 , 86 , 87 , 88 , 89 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ,…”

Section: Effects Of Biological Sexmentioning

confidence: 99%

Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy

García‐Llorca

Kararigas

2023

Microorganisms

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The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR.

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“…Cardiovascular diseases (CVD) are one of the leading causes of death globally [1]. Notably, there are pronounced sex differences in the development and outcome of CVD, as well as the response to pharmacological therapies [2][3][4][5][6][7][8][9]. Genetic and epigenetic mechanisms, fibrotic, inflammatory and metabolic processes, as well as sex steroid hormones and their receptors are expected to account for sex-biased CVD development and outcome [8,[10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%