Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder

Hu, Xinyue; Zhang, Lianqing; Liang, Kaili; Cao, Lingxiao; Liu, Jing; Li, Hailong; Gao, Yingxue; Hu, Xinyu; Hu, Yu‐Chen; Kuang, Weihong; Sweeney, John A.; Gong, Qiyong; Huang, Xiaoqi

doi:10.1038/s41386-021-01252-7

Cited by 20 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prominent sex differences in MDD have been well established ( 30 ). Patients with MDD show sex differences in terms of gene expression ( 31 ), endocrine system ( 32 ), and cortical morphometry ( 19 ). However, there are relatively few studies on sex differences in adolescent MDD.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, epidemiological studies have shown that females are more prone to depression than males ( 18 ). Studies have demonstrated sex differences in brain morphology of patients with adult MDD ( 19 , 20 ). In addition, amygdalar volumes in healthy adolescents also showed sex divergence ( 21 ); the left amygdala was smaller in girls than in boys.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundThe neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.Materials and methodsFifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.ResultsCompared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.ConclusionThese findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Moreover, MRI studies have been conducted in MDD patients of different sexes to provide some implications for the understanding of the differences in neuropathological mechanisms between the sexes. [ 16 , 17 , 18 ]. In terms of brain structure, A study found that the surface area (SA) of the left ventrolateral prefrontal cortex was significantly reduced in the female MDD, whereas the SA was increased in the male MDD [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 16 , 17 , 18 ]. In terms of brain structure, A study found that the surface area (SA) of the left ventrolateral prefrontal cortex was significantly reduced in the female MDD, whereas the SA was increased in the male MDD [ 18 ]. Another study found that the gray matter (GM) of the limbic system region had lower in the female MDD, whereas the GM of the striatal region had lower in the male MDD [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study

Sun

Luo

et al. 2022

Brain Sciences

View full text Add to dashboard Cite

The presence of different clinical symptoms in patients with treatment-resistant depression (TRD) of different sexes may be related to different neuropathological mechanisms. A total of 16 male patients with TRD, 18 female patients with TRD, 18 male healthy controls (HCs) and 19 female HCs completed this study. We used the amplitude of low frequency fluctuations (ALFF) method to analyze the results. Moreover, the correlation between abnormal brain areas and clinical symptoms in different sexes of the TRD groups was also analyzed. The effects of the sex-by-group interaction difference in ALFF among the four groups was located in the left middle frontal gyrus, left precentral gyrus and left precuneus. Post hoc comparisons revealed that the male TRD group had lower ALFF in the left middle frontal gyrus and left precentral gyrus compared with the female TRD group. There was a positive correlation between the left middle frontal gyrus, the left precuneus and the 17-item Hamilton Rating Scale for Depression scale (HAMD-17) scores, and a negative correlation between the left precentral gyrus and the HAMD-17 scores in the female TRD group. This study will provide some clinical reference value for the sex differences in neuropathological mechanisms of TRD.

show abstract

“…A voxel-based morphometric (VBM) study showed smaller gray matter volumes (GMVs) in the bilateral middle temporal gyrus and left ventromedial prefrontal cortex (vPFC) in the male MDD group and smaller GMVs in the left dorsomedial prefrontal cortex (DLPFC) and lingual gyrus in the female MDD group compared with the matched HC group [ 28 ]. Another study found that the female MDD group exhibited a significantly lower surface area (SA) in the left ventrolateral prefrontal cortex (vlPFC) and significantly lower cortical volume (CV) in the right rostromedial prefrontal cortex (rmPFC), while the male MDD group exhibited a higher SA in the left vlPFC and higher CV in the right rmPFC [ 29 ]. It was also found that there was lower baseline fractional anisotropy in a portion of the left precentral gyrus white matter in the female MDD group, while the male MDD group showed the opposite pattern [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

Sun

Gao

et al. 2022

Brain Sciences

View full text Add to dashboard Cite

In this study, we observed the sex differences in functional brain activity in patients with recurrent depressive disorder (RDE) and assessed the correlation between abnormal functional brain activity changes and clinical symptoms. A total of 40 patients with RDE (19 male and 21 female) and 42 healthy controls (HCs) (20 male and 22 female) met the inclusion criteria. Analysis of images using regional homogeneity (ReHo) and further analysis of the correlation between abnormal brain areas and clinical symptoms of the different sexes with RDE groups were carried out. For the main effects of sex (male vs. female), there were statistically significant differences in ReHo among the four groups in the right middle temporal gyrus, right thalamus, and left posterior cerebellar lobe. For the effects of the sex-by-group interaction, there were statistically significant differences in ReHo among the four groups in the left middle frontal gyrus, left precentral gyrus, and right insula. Post hoc analyses showed that compared with the female RDE group, the male RDE group had decreased ReHo in the left middle frontal gyrus and right insula. In the female RDE group, the ReHo values of the left middle frontal gyrus were positively correlated with the 17-item Hamilton Rating Scale for Depression (HAMD-17) scores. This study provides new insights into the clinical targeting of different sexes for RDE.

show abstract

Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder

Cited by 20 publications

References 64 publications

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

Contact Info

Product

Resources

About