Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

Chen, Li‐Hua; Zhong, Chongke; Xu, Tan; Xu, Tian; Peng, Yi; Wang, Aili; Wang, Jinchao; Peng, Hao; Li, Qunwei; Ju, Zhong; Geng, Deqin; Zhang, Jintao; Li, Yongqiu; Zhang, Yonghong; He, Jiang

doi:10.1038/srep38351

Cited by 19 publications

(17 citation statements)

References 33 publications

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“…The population had a marked female predominance, which is consistent with several previous studies. 3,[17][18][19] In addition, the average age close to 40 years old also agrees with the different epidemiological reports worldwide, where it is estimated that the pathology has higher prevalence in patients between 25 and 55 years of age. 1,3,[20][21][22] Regarding the diagnoses, the proportion of migraine without aura (37%) was similar to a previous study in the Colombian population (43%).…”

Section: Discussionsupporting

confidence: 88%

Prescription Patterns Of Antimigraine Drugs

Machado‐Duque¹,

Gaviria‐Mendoza²,

Machado‐Alba³

2021

revecuatneurol

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Objetivo: Determinar los patrones de prescripción de medicamentos antimigrañosos en una población de Colombia. Métodos: Estudio de corte a partir de una base de datos poblacional que recogió todos los pacientes con diagnóstico de migraña y los medicamentos empleados para el tratamiento de crisis y profilaxis. Se hicieron análisis multivariados para identificar variables asociadas con uso de profilaxis. Resultados: Se identificaron 5973 pacientes con diagnóstico de migraña, con edad media de 37,7±14,5 años y predominio femenino (81,3%). El diagnóstico más común fue migraña sin aura (n=2207; 36,9%), seguido de migraña con aura (n=1697; 28,4%); el 7,3% fue atendido por neurología, 1,9% por medicina interna y 92,8% por medicina general. El 85,4% (n=5101) recibió tratamiento para los episodios agudos y los antiinflamatorios no esteroideos (n=3112; 52,1%) fueron los fármacos más empleados, seguidos de ergotamina (n=2513; 42,1%). El 46,3% (n=2766) estaban recibiendo medicamentos para profilaxis. Las mujeres, mayores de 35 años y aquellos atendidos por neurología tuvieron mayor probabilidad de recibir profilaxis. Conclusiones: Predominó el uso de medicamentos para manejo agudo. Pese a los importantes efectos indeseables, la ergotamina sigue empleándose con frecuencia. Los médicos deben evaluar la necesidad de profilaxis enfocados en buscar una terapia efectiva que reduzca las incapacidades. Palabras clave: acetaminofen, antiinflamatorios no esteroideos, ergotamina, Farmacoepidemiología, migraña con aura, migraña sin aura, Trastornos migrañosos

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Section: Discussionsupporting

confidence: 88%

Prescription Patterns Of Antimigraine Drugs

Machado‐Duque¹,

Gaviria‐Mendoza²,

Machado‐Alba³

2021

revecuatneurol

View full text Add to dashboard Cite

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“…A meta-analysis indicated that the serum uric acid level had a protective effect on neurological outcomes after acute ischemic stroke [22]. Further study showed elevated serum uric acid was positively associated with a better prognosis in men, but not in women [23]. In the present study, we did not find an association between the degree of artery stenosis and uric acid.…”

Section: Discussioncontrasting

confidence: 71%

Serum Calcium is Related to the Degree of Artery Stenosis in Acute Ischemic Stroke

Xie

Zhao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Acute ischemic stroke is caused by stenosis of artery supplying to brain. We aimed to detect some metabolites in the serum that would be related to the degree of artery stenosis and to analyze potential mechanisms. Methods: Patients diagnosed with acute ischemic stroke were divided into two groups according to their degree of artery stenosis (which was determined by computed tomographic angiography): a mild group (stenosis ≤ 30%) and a severe group (stenosis > 30%). Serum from these patients was collected, and we focused on the differences in the concentrations of calcium, uric acid, low density lipoprotein and homocysteine. The dataset GSE11583 from the Gene Expression Omnibus database was analyzed to find the potential mechanism using bioinformatics methods. Results: Among the four metabolites, the only difference that reached significance between the two groups was in the concentration of calcium in serum (2.27±0.08 mmol/L vs 2.21±0.08 mmol/L). By comparing the gene expression levels between normal endothelial cells and adaptive remodeling endothelial cells in GSE11583, we identified 51 upregulated and 40 downregulated genes in adaptive remodeling endothelial cells. The gene set enrichment analysis revealed that upregulated genes were enriched in a phosphatidylinositol signaling system, which is closely involved in the calcium signaling pathway. Conclusion: Our results suggest that the concentration of serum calcium is higher in patients with more severe artery stenosis lesions and that the phosphatidylinositol signaling system is a key biological pathway involved in this process.

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“…Despite the fact that hyperuricemia often occurs in SLE patients, the association between LN and hyperuricemia remains insufficiently studied. Furthermore, serum uric acid levels have been reported to have variable effects on chronic heart failure [15], cardiac hypertrophy in CKD patients [16], acute ischemic stroke [17] and IgAN [18], depending on sex; nevertheless, its sex-specific effect on LN remains unclear. In an analysis of the Korean National Health Insurance system, the prevalence of SLE in Korea was reported to be 18.8-21.7 per 100,000 people in 2006 and has been increasing since [19].…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Choi

Kim

et al. 2020

JCM

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Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

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Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

Cited by 19 publications

References 33 publications

Prescription Patterns Of Antimigraine Drugs

Prescription Patterns Of Antimigraine Drugs

Serum Calcium is Related to the Degree of Artery Stenosis in Acute Ischemic Stroke

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

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