Sex-specific changes in oxidative stress parameters and longevity produced by Bisphenol F and S compared to Bisphenol A in Drosophila melanogaster

Musachio, Elize Aparecida Santos; Poetini, Márcia Rósula; Janner, Dieniffer Espinosa; Meichtry, Luana Barreto; Poleto, Ketnne Hanna; Fernandes, Eliana Jardim; Guerra, Gustavo Petri; Prigol, Marina

doi:10.1016/j.cbpc.2022.109329

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…Moreover, BPF exposure led to metabolic disorders in the liver due to changes observed in the levels of 8 key metabolites 20 . Musachio et al 34 found sex-speci c changes in oxidative stress parameters in Drosophila melanogaster after BPF exposure for seven days. Female ies were more susceptible to oxidative cell damage and reduced its longevity.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring

Linillos-Pradillo

Rancán

Murias

et al. 2023

Preprint

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Bisphenol F (BPF) is replacing Bisphenol A (BPA) in the manufacture of products due to endocrine-disrupting effects. BPF monomers can also be released into the environment and enter the food chain, resulting in human exposure to low doses. Since bisphenols are primarily metabolized by the liver, this organ is more vulnerable to lower doses of bisphenols than others. Exposure during prenatal development may increase the risk of diseases in adulthood. The aim was to evaluate whether BPF administration could generate oxidative stress in liver of lactating rats, and whether these effects may be also observed in female and male postnatal day 6 (PND6) offspring. Long Evans rats received oral treatment: Control, BPF-low-dose (LBPF) 0.0365 mg/kg b.w./day, and BPF-high-dose (HBPF) 3.65 mg/kg b.w./day. The levels of antioxidant enzymes (CAT, SOD, GR, GPx and GST), glutathione system (GSH, GSSG) and lipid damage markers (MDA, LPO) were measured using colorimetric methods in liver of both lactating dams and in PND6 offspring. Mean values were analyzed using Prism-7. LBPF affected liver defense mechanisms (antioxidant enzymes and glutathione system), increasing ROS levels and producing lipid peroxidation in lactating dams. Similar effects were found in female and male PND6 offspring as a consequence of perinatal exposure.

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Section: Discussionmentioning

confidence: 99%