Sexual dimorphism in vestibular function and dysfunction

Smith, Paul F.; Agrawal, Yuri; Darlington, Cynthia L.

doi:10.1152/jn.00074.2019

Cited by 37 publications

(32 citation statements)

References 81 publications

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“…Although the exact causes of Meniere’s disease are not clear, endolymphatic hydrops are likely causative of this disease [ 53 ]. Several reports had revealed a slight female preponderance in Meniere’s disease [ 54 , 55 ]. Those who had a lower estrogen level presented poor auditory function in postmenopausal patients with Meniere’s disease [ 56 ].…”

Section: Clinical Aspects Of Sex Differences In Acquired Sensorineural Hearing Lossmentioning

confidence: 99%

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Lien

Yang

2021

IJMS

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The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.

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Section: Clinical Aspects Of Sex Differences In Acquired Sensorineural Hearing Lossmentioning

confidence: 99%

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Lien

Yang

2021

IJMS

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“…Tinnitus can be associated with a range of physical and mental conditions (Baguley et al, 2013), some of which appear relevant for bothersome tinnitus (Basso et al, submitted). Many of these conditions, like cardiovascular diseases (Regitz-Zagrosek and Kararigas, 2017), chronic musculoskeletal pain (Wijnhoven et al, 2006), thyroid diseases (Vanderpump et al, 1995), Ménière's disease (Smith et al, 2019), depression (Salk et al, 2017), and anxiety disorders (Bandelow and Michaelis, 2015) are marked by gender differences.…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus

et al. 2020

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Objective: This study aims to identify gender-specific risk factors associated with the presence of bothersome tinnitus (compared with non-bothersome tinnitus), including sociodemographic and lifestyle factors, tinnitus-associated phenomena (hearing loss, traumatic experiences, sleep disturbances), and physical as well as mental comorbidities. Methods: We conducted a cross-sectional study using survey data from the Swedish LifeGene cohort containing information on self-reported tinnitus (N = 7615). We (1) analyzed risk factor and comorbidity frequencies, (2) computed multivariate logistic regression models to identify predictors of bothersome tinnitus within both genders, and (3) moderated logistic regression models to compare effects between genders. Results: (1) The majority of factors that differed in frequencies between bothersome and non-bothersome tinnitus were equal for both genders. Women with bothersome tinnitus specifically reported higher rates of cardiovascular disease, thyroid disease, epilepsy, fibromyalgia, and burnout, and men with bothersome tinnitus reported higher rates of alcohol consumption, Ménière's disease, anxiety syndrome, and panic (compared with non-bothersome tinnitus, respectively). (2) Across both genders, multivariate logistic regression analyses revealed significant associations between bothersome tinnitus and age, reduced hearing ability, hearingrelated difficulties in social situations, and reduced sleep quality. In women, bothersome tinnitus was specifically associated with cardiovascular disease and epilepsy; in men, with lower education levels and anxiety syndrome. (3) Moderated logistic regression analyses revealed that the effects of low education and anxiety syndrome were present in men, but not in women, whereas the effects of age, reduced hearing ability and related difficulties, cardiovascular disease, epilepsy, and burnout were not gender specific. Conclusion: Irrespective of gender, bothersome tinnitus is associated with higher age, reduced hearing ability, hearing-related difficulties, cardiovascular disease, epilepsy, and

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“…Since the aromatase in the cerebellum and brainstem in rodents has very similar expression to that detected in humans, one can also hypothesize similar vestibulo-cerebellar mechanisms controlled by nE2 and leading to motor learning in these two species [66,79,80,83]. A cardinal consequence that extends this concept is that nE2 could influence human perceptive and motor phenomena that require adaptive process and plasticity in the vestibulo-cerebellar networks in physiological as well as pathological conditions [172][173][174][175][176]. Thus, nE2 may exert its influence not only on VOR adaptation but even on the rebalancing after labyrinthine lesion of vestibular reflexes and perception [177][178][179] and on other motor behaviors like balance and locomotion requiring the computational power of cerebellar networks to adapt responses to the context [120,128,180,181].…”

Section: Implications For the Impact Of Ne2 On The Cerebellar Functionmentioning

confidence: 84%

De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function

Dieni

Contemori

Biscarini

et al. 2020

IJMS

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The estrogen estradiol is a potent neuroactive steroid that may regulate brain structure and function. Although the effects of estradiol have been historically associated with gonadal secretion, the discovery that this steroid may be synthesized within the brain has expanded this traditional concept. Indeed, it is accepted that de novo synthesized estradiol in the nervous system (nE2) may modulate several aspects of neuronal physiology, including synaptic transmission and plasticity, thereby influencing a variety of behaviors. These modulations may be on a time scale of minutes via non-classical and often membrane-initiated mechanisms or hours and days by classical actions on gene transcription. Besides the high level, recent investigations in the cerebellum indicate that even a low aromatase expression can be related to the fast nE2 effect on brain functioning. These pieces of evidence point to the importance of an on-demand and localized nE2 synthesis to rapidly contribute to regulating the synaptic transmission. This review is geared at exploring a new scenario for the impact of estradiol on brain processes as it emerges from the nE2 action on cerebellar neurotransmission and cerebellum-dependent learning.

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Sexual dimorphism in vestibular function and dysfunction

Cited by 37 publications

References 81 publications

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus

De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function

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