Sexual dysfunction in a cohort of patients with moderate‐to‐severe atopic dermatitis. Influence of dupilumab treatment

Linares‐González, Laura; Lozano-Lozano, Ignacio; Gutiérrez‐Rojas, Luis; Ruiz‐Villaverde, Ricardo; Lozano‐Lozano, Mario

doi:10.1111/ijd.15938

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…A few studies have addressed the sexual life of patients with AD, but most of them have focused mainly on male sex ( 18 , 23 , 24 ). One Dutch study with a small sample size found that sexual satisfaction and self-perception of appearance in women with AD is significantly lower than in general populations.…”

Section: Discussionmentioning

confidence: 99%

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

Fougerousse,

Alexandre,

Darrigade

et al. 2024

Acta Derm Venereol

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Atopic dermatitis (AD) is one of the most common inflammatory diseases, and has a higher prevalence among females in adulthood. The aim of this observational, cross-sectional, survey-based study was to evaluate the impact of AD on the daily lives of adult women patients. A scientific committee composed exclusively of women constructed a specific questionnaire in partnership with the French Eczema Association. Severity of AD was evaluated with the Patient-Oriented Eczema Measure (POEM). A sample of 1,009 adult women (mean age ± standard deviation: 41.8 ± 14.2 years) with AD was identified from a representative sample of the French population (82% response rate 1,230 women surveyed). According to the POEM, 50.64% (n = 511) of subjects were identified as having mild AD, 39.35% (n = 397) moderate AD, and 10.01% (n = 101) severe AD. Overall, 67.7% (n = 682) reported that their eczema involved a visible area (face, neck or hands), and 19.6% (n = 198) a sensual area (breasts/chest, genital area or buttocks). Of the 720 women with menstrual cycles, exacerbations of AD were reported to occur mostly before (50.6%) and during (48.3%) menstruation. A small proportion of women, 7.3% (n = 74), reported being afraid of becoming pregnant because of their eczema. If AD involvement was in a visible area it had a greater impact on romantic relationships, sexual relationships and occupation. If AD involvement was in a sensual area it had a greater influence on romantic relationships and sexuality. Particular attention should be given to patients with localization of AD on the face, neck or hands, as they have a higher risk of social exclusion. Moreover, these results should encourage health professionals to ask patients with AD about the possible involvement of sensual areas.

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Section: Discussionmentioning

confidence: 99%

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

Fougerousse,

Alexandre,

Darrigade

et al. 2024

Acta Derm Venereol

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“…In the questionnaire applied, one of the main topics we may highlight is the fact that AD affects the sexual life of women of childbearing age [ 13 , 14 ]. The sexual life of patients with atopic dermatitis of longer evolution (>13 years) is significantly affected compared to patients with less evolution in time (<13 years) (6.00 ± 2.42 vs. 7.32 ± 2.80; p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Validation of a Questionnaire to Assess the Perception of Women with Atopic Dermatitis in Family Planning

Alcantara-Luna

Ruíz‐Villaverde

Domínguez-Cruz

et al. 2022

IJERPH

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Introduction: Atopic dermatitis (AD) is a highly frequent chronic inflammatory skin disease. It is important to know how women with AD approach family planning together with their disease. The aim of the present research is to develop and validate a questionnaire for women diagnosed with AD in order to measure their level of desire and gestational information. Materials and Methods: A multicenter cross-sectional study was conducted. Women between 18 and 45 years old with mild, moderate, and severe forms of the disease were included and disease-free controls. An exploratory factorial analysis of the primary components and varimax rotation was used to measure the validity of the construct. Cronbach’s α was used to measure the reliability of the individual scales and the global questionnaire. Results: In total, 150 valid questionnaires were included. The final questionnaire consisted of 23 items that converged on six factors. The six scales had adequate reliability: “Pregnancy” (Cronbach’s alpha = 0.95), “Conception” (Cronbach’s alpha = 0.93), “Concern-information” (Cronbach’s alpha = 0.82), “Breastfeeding” (Cronbach’s alpha = 0.81), “Sexual life” (Cronbach’s alpha = 0.79), and “Family planning” (Cronbach’s alpha = 0.67). The total Cronbach’s alpha of the questionnaire was 0.94. Discussion: This questionnaire is the first specific measurement instrument developed for women with AD of childbearing age that has demonstrated adequate levels of reliability and construct validity. We consider it useful and valuable to study aspects such as family planning in this patient profile, and that can influence their decision to have offspring.

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“…Sexual health impairment has not been consistently assessed in patients with AD, despite the societal and personal importance of sex and its key role within patient-reported outcomes and impact on QoL [1,5,6]. It has been observed that AD patients are more likely to report sexual dysfunction than healthy controls [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The convergence of a proinflammatory state, abnormal hormonal levels and the psychological impact of eczema on genital areas might explain the high levels of sexual dysfunction reported by male and 2 of 10 female patients with AD [9,10]. Nevertheless, to date, only one report has evaluated the impact of an adequate treatment on sexual dysfunction in patients with AD [5].…”

Section: Introductionmentioning

confidence: 99%

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Improvement of Sexual Function and Sleep Quality in Patients with Atopic Dermatitis Treated with Dupilumab: A Single-Centre Prospective Observational Study

Ureña-Paniego

Montero‐Vílchez

Torre

et al. 2023

IJERPH

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Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting as xerosis, eczema and intense pruritus. These symptoms negatively impact patients’ quality of life. However, the effect of AD on sexual function and sleep quality and how treatment with dupilumab could modify them have not been explored in depth. The aim of this study is to assess the effects of dupilumab on sexual and sleep quality in patients with AD. For that purpose, an observational prospective study was designed. Patients were evaluated at baseline and after 16 weeks of dupilumab treatment. Disease severity was assessed by Eczema Area and Severity (EASI) and SCORing Atopic Dermatitis index (SCORAD). Sexual function was evaluated using validated questionnaires, for men via the International Index of Erectile Dysfunction 5 (IIEF-5) and for women via the Female Sexual Function Index (FSFI). Sleep impairment was recorded through Pittsburgh Sleep Quality Index (PSQI). Thirty-two patients, with a mean age of 30.53 ± 14.48 years old, were included. Regarding sex, 59.8% (20) were female. Most patients had a severe disease reflected in a mean basal EASI of 23.24 ± 6.74 and a SCORAD of 54.07 ± 13.89. Clinical scores improved after dupilumab treatment. At baseline, 47.37% women presented sexual dysfunction and 66.67% men had erectile dysfunction. FSFI improved from 23.51 to 27.93 points (p = 0.008) after dupilumab. Desire, arousal, satisfaction and pain were the components with great improvement. Women with a great improvement in FSFI showed greater clinical results and increased quality of life. At first, 96.9% (31/32) of participants presented with poor sleep quality. After treatment with dupilumab, sleep quality was enhanced and PSQI scores decreased from 12.8 points at baseline to 7.73 points (p < 0.001). In conclusion, dupilumab is associated with reduced sexual dysfunction, mainly in women, and sleep quality.

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Sexual dysfunction in a cohort of patients with moderate‐to‐severe atopic dermatitis. Influence of dupilumab treatment

Cited by 4 publications

References 17 publications

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

Validation of a Questionnaire to Assess the Perception of Women with Atopic Dermatitis in Family Planning

Improvement of Sexual Function and Sleep Quality in Patients with Atopic Dermatitis Treated with Dupilumab: A Single-Centre Prospective Observational Study

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