Sexual function in women with systemic lupus erythematosus: a case–control study

Serna-Peña, Griselda; Colunga-Pedraza, I. J.; Villarreal-Alarcón, Miguel Ángel; Castillo‐Torres, Sergio A.; Abundis-Márquez, E.E.; Reynosa-Silva, Ileana Cecilia; Galarza‐Delgado, Dionicio Ángel

doi:10.1007/s00296-021-04895-3

Cited by 5 publications

(9 citation statements)

References 14 publications

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“…fatigue, depression, disease activity) of female sexual problems using the FSFI in SLE patients from mainland China. The prevalence of female sexual problems in our SLE patients was 78.9%, higher than that reported in other studies using the FSFI (García et al reported 45.9% [10], Cheng et al 52.6% [13], and Serna-Peña et al 28% [11]), which could be explained by the existence of conservative Asian culture and the different participants included in different studies with either Chinese or Western cohorts. All of these findings that female sexual problems should be included as part of the routine care for detection and management.…”

Section: Discussioncontrasting

confidence: 75%

“…Previous studies [10][11][12][13][14] have reported that many reasons may lead to female sexual problems such as demographic characteristics, psychological problems, disease activity and drug usage etc. Our univariate analysis of demographic factors was consistent with previous studies showing that patients with female sexual problems had older age, no child, and poor marital status.…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis [8] revealed the rate of sexual dysfunction (SD) in SLE patients, ranging from 15% to 85.9%, which indicated the severity of the poor assessment and management of these issues. Over the past several years, only a handful of studies [9][10][11][12] used a validated tool of the Female Sexual Function Index (FSFI) to explore the relationship between SLE and sexual problems, demonstrating that SLE was associated with an increased risk of female sexual problems. Tseng et al [13] have reported that 52.5% have sexual problems in Taiwan SLE patients.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies [9][10][11][12]14] have found that several factors were associated with female sexual problems in SLE patients, such as age, number of children, marital satisfaction, economic status, pain, disease duration, disease activity, certain psychological problems like depression and anxiety, functional status, and quality of life. Other factors such as higher dose of steroids also possibly result in female sexual problems [12].…”

Section: Introductionmentioning

confidence: 99%

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Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

Zhang

2022

BMC Women's Health

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Background Systemic lupus erythematosus (SLE) might affect all aspects of life including sexual function; previous study indicated that fatigue was the risk factor of sexual dysfunction. The current study aims to investigate the effects of SLE on Chinese mainland female patients’ sexual problems compared with healthy subjects and to investigate the relationship among fatigue, disease parameters, depression, quality of life and sexual problems in Chinese female patients with SLE. Methods A total of 128 female SLE patients (mean age: 43.65 ± 7.13 years) and 121 healthy female controls (mean age 43.59 ± 6.57 years) were included in this cross-sectional study. All data were collected consecutively by face-to-face questionnaires from January 2021 to December 2021. SLE patients completed questionnaires for demographic or clinical variables, the 10-cm Visual Analog Scale for pain, the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) for disease activity, the multidimensional fatigue inventory (MFI) for fatigue, the patient health questionnaire-9 (PHQ-9) for depression, the Female Sexual Function Index (FSFI) for problems, and the Short Form 12 health survey for quality of life. Independent sample t-test, Mann–Whitney U-test, Chi-square test, and forward stepwise binary logistic regression model were used to analyze these data. Results Our results showed that the prevalence of female sexual problems was 78.9% in SLE patients, which was significantly higher than the controls (56.7%; p < 0.05). The results found that having child (OR 23.04; p < 0.000), age (OR 1.11; p = 0.002), DMARDs usage (OR 0.04; p = 0.004), MFI total score (OR 1.06; p = 0.006), and disease duration (OR 1.16; p = 0.043) were the potential risk factors of female sexual problems by forward stepwise binary logistic regression. Conclusion The present study reported that female sexual problems was more common in Chinese SLE female patients compared to controls. Having child, age, DMARDs usage, fatigue, and disease duration had great impacts on female sexual problems in Chinese SLE patients. Rheumatologists and nurses should pay close attention to SLE female patients’ sexual problems, especially those having no child, older age, not using DMARDs, fatigue, or long disease duration by health education or other methods to improve their sexual problems, and ultimately improve SLE patients’ quality of life.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

Zhang

2022

BMC Women's Health

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“…A total of 367 records were retrieved from the 3 aforementioned electronic databases. Five studies that involved 710 women with SLE and 2,059 healthy women were finally included in the meta-analysis [12][13][14][15][16]. The flow diagram for study selection is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

2022

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Background Systemic lupus erythematosus (SLE), a chronic systemic autoimmune disease, often affects different organs and tissues. It can be effectively managed using drugs; however, attention should be paid to the patient’s quality of life. This study aimed to evaluate the effect of SLE on female sexual function based on current literature. Methods The PubMed, Embase, and Cochrane Library databases were searched for eligible studies published up to November 9, 2021. This review included all English studies that compared the sexual function between women with SLE and healthy women. A meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results A total of 367 records were retrieved from 3 electronic databases. Five studies that involved 710 women with SLE and 2059 healthy women were finally included in this meta-analysis. The result indicated a significant decrease (mean difference = − 1.74, 95% confidence interval − 3.14 to − 0.34, p = 0.02) in the total scores of the Female Sexual Function Index in women with SLE, implying that healthy women had better sexual function than those with SLE. Conclusion The results of our study indicated that SLE could negatively affect the quality of sexual life in terms of desire, arousal, and pain. Thus, close attention should be paid to the sexual function of women with SLE. Trial registration: This study was registered in the International Prospective Register of Systematic Reviews (registration number: CRD42021290439).

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Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction

Yessirkepov,

Kocyigit,

Zhakipbekov

et al. 2024

Rheumatol Int

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Inflammatory rheumatic diseases (IRDs) refer to a range of persistent disorders that have a major influence on several physiological systems. Although there is much evidence connecting IRDs to sexual dysfunction and fertility problems, research specifically focusing on male infertility in relation to these diseases is sparse. This review addresses the complicated connection between IRDs and male infertility, emphasising the physiological, psychological, and pharmacological aspects that influence reproductive health outcomes in men with rheumatic conditions. We explore the effects of IRDs and their treatments on many facets of male reproductive well-being, encompassing sexual functionality, semen characteristics, and hormonal balance. Additionally, we present a comprehensive analysis of the present knowledge on the impact of several categories of anti-rheumatic drugs on male reproductive function. Although there is an increasing awareness of the need of addressing reproductive concerns in individuals IRDs, there is a noticeable lack of research especially dedicated to male infertility. Moving forward, more comprehensive research is needed to determine the prevalence, risk factors, and mechanisms driving reproductive difficulties in males with IRDs. We can better assist the reproductive health requirements of male IRD patients by expanding our understanding of male infertility in the setting of rheumatic disorders and implementing holistic methods to care.

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Sexual function in women with systemic lupus erythematosus: a case–control study

Cited by 5 publications

References 14 publications

Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction

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