2016
DOI: 10.1159/000438636
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SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5)

Abstract: Background: The serum & glucocorticoid inducible kinase isoform SGK3 is a powerful regulator of several transporters, ion channels and the Na+/K+ ATPase. Targets of SGK3 include the ubiquitin ligase Nedd4-2, which is in turn a known regulator of the voltage gated K+ channel Kv1.5 (KCNA5). The present study thus explored whether SGK3 modifies the activity of the voltage gated K+ channel KCNA5, which participates in the regulation of diverse functions includ… Show more

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Cited by 6 publications
(5 citation statements)
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“…NALCN is essential for mammalian survival; however, the gating, ion selectivity and pharmacological properties of NALCN remain unclear (Chua et al 2020 ; Kschonsak et al 2020 ). The KCNA5 gene encodes potassium voltage-gated channel subfamily A member 5, which is involved in the regulation of several functions including cardiac action potential, vascular smooth muscle cell activity, insulin release and tumour cell proliferation (Bossini-Castillo et al 2012 ; Ahmed et al 2016 ). The CACNA2D1 gene encodes a calcium voltage-gated channel α2δ-1 subunit, which enhances channel transport, increases the expression of functional calcium channels at the plasma membrane and affects the biophysical properties of the channel (Dolphin 2012 ).…”
Section: Discussionmentioning
confidence: 99%
“…NALCN is essential for mammalian survival; however, the gating, ion selectivity and pharmacological properties of NALCN remain unclear (Chua et al 2020 ; Kschonsak et al 2020 ). The KCNA5 gene encodes potassium voltage-gated channel subfamily A member 5, which is involved in the regulation of several functions including cardiac action potential, vascular smooth muscle cell activity, insulin release and tumour cell proliferation (Bossini-Castillo et al 2012 ; Ahmed et al 2016 ). The CACNA2D1 gene encodes a calcium voltage-gated channel α2δ-1 subunit, which enhances channel transport, increases the expression of functional calcium channels at the plasma membrane and affects the biophysical properties of the channel (Dolphin 2012 ).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the effect was abolished by coexpression of SGK1 [89]. SGK3 influences some ion channels by phosphorylating and thus inactivating the ubiquitin ligase Nedd4-2, which otherwise ubiquitinates target proteins thus labelling them for degradation [15,[114][115][116][117]. However, whether the large conductance Ca 2+ -activated K + channels are targeted by Nedd4-2, remains uncertain.…”
Section: Discussionmentioning
confidence: 99%
“…The activation of all three kinases is similar to that for AKT and is controlled by a priming phosphorylation by PI3K/PDK1 and activating phosphorylation by mTORC2 17 . The most well characterized SGK family substrates are members of the N-myc downstream regulated (NDRG) family in addition to several Na + /K + ion channels [18][19][20][21][22] . All three SGKs are linked to cancer either by promoting drug resistance or by controlling pathways important for cancer progression 15 .…”
Section: Introductionmentioning
confidence: 99%