“…3b, c, however, SGLT1 is heavily expressed in tumor tissue suggesting that SGLT1 similarly contributes to glucose uptake of tumor cells. Expression of SGLT1 in tumor tissue has been demonstrated before [8,13,17,28,31,40,41,63]. In view of the enhanced demand of tumor cells for nutrients and the respective upregulation of glucose and amino acid transport in tumor cells [9,14,15,23,24,27,32,46,64], the upregulation of SGLT1 activity by β-catenin may contribute to the proliferation and survival of tumor cells.…”