2015
DOI: 10.3389/fncel.2015.00094
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Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Abstract: Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored. In the present study, we generated mice lacking Shank3 exon 9 (Shank3Δ9 mice), and thus missing five out of 10 known Shank3 splice variants containing the N-terminal ankyrin repeat region, including the longest splice variant, Shank3a. Our X-gal staining results revealed that Shank3 proteins encode… Show more

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Cited by 141 publications
(165 citation statements)
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“…) and finally a mouse with an exon 9 deletion lacking the ankyrin repeat region was recently generated [ Shank3 (9) ] (Lee et al . ).…”
Section: Mouse In Vivo Modeling Of Shank Mutationsmentioning
confidence: 97%
“…) and finally a mouse with an exon 9 deletion lacking the ankyrin repeat region was recently generated [ Shank3 (9) ] (Lee et al . ).…”
Section: Mouse In Vivo Modeling Of Shank Mutationsmentioning
confidence: 97%
“…For instance, E/I imbalance can occur in cortical regions due to mutations in synaptic proteins such as Shank 98, 101 , a family of key PSD proteins located in glutamatergic synapses that, together with other postsynaptic proteins (SAPAP and PSD-95), forms a postsynaptic scaffolding complex (Figure 2) 102104 . While ASD is considered a polygenic disorder in most cases, recent studies showed that genetic disruption of Shank2 and Shank3 in mice results in substantial physiological and biochemical alterations at synapses that may contribute to impaired social behavior 99, 105110 .…”
Section: Etiology Of Social Behavior Abnormalitiesmentioning
confidence: 99%
“…An altered E/I balance has also been reported in mouse models of several psychiatric disorders (Gandal et al, 2012; Gkogkas et al, 2013; Lee et al, 2015). …”
Section: Resultsmentioning
confidence: 83%