Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Andrade, Raquel G. D.; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.

doi:10.3390/ijms21072455

Cited by 130 publications

(83 citation statements)

References 194 publications

(211 reference statements)

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“…Moreover, the sigmoidal shape of the loop is characteristic of nanostructures with small magnetic fields [65]. The weak magnetism could be due to the presence of a higher amount of Fe 2 O 3 phase which is also evidenced by the XRD [66].…”

Section: Vibrating Sample Magnetometer (Vsm) (Magnetization Study)mentioning

confidence: 81%

“…The disappearance of hysteresis with a little remanence and coercivity (Hc), indicates the absence as a long-range magnetic dipole-dipole interaction among the assemblies of superparamagnetic nanoparticles [64]. Moreover, the sigmoidal shape of the loop is characteristic of nanostructures with small magnetic fields [65]. The weak magnetism could be due to the presence of a higher amount of Fe2O3 phase which is also evidenced by the XRD [66].…”

Section: Vibrating Sample Magnetometer (Vsm) (Magnetization Study)mentioning

confidence: 88%

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Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

et al. 2020

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Nanoparticles have gained huge attention in the last decade due to their applications in electronics, medicine, and environmental clean-up. Iron oxide nanoparticles (IONPs) are widely used for the wastewater treatment due to their recyclable nature and easy manipulation by an external magnetic field. Here, in the present research work, iron oxide nanoparticles were synthesized by the sonochemical method by using precursors of ferrous sulfate and ferric chloride at 70 °C for one hour in an ultrasonicator. The synthesized iron oxide nanoparticles were characterized by diffraction light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), electron diffraction spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM) and vibrating sample magnetometer (VSM). The FTIR analysis exhibits characteristic absorption bands of IONPs at 400–800 cm−1, while the Raman spectra showed three characteristic bands at 273, 675, and 1379 cm−1 for the synthesized IONPs. The XRD data revealed three major intensity peaks at two theta, 33°, 35°, and 64° which indicated the presence of maghemite and magnetite phase. The size of the spherical shaped IONPs was varying from 9–70 nm with an average size of 38.9 nm while the size of cuboidal shaped particle size was in microns. The purity of the synthesized IONPs was confirmed by the EDS attached to the FESEM, which clearly show sharp peaks for Fe and O, while the magnetic behavior of the IONPs was confirmed by the VSM measurement and the magnetization was 2.43 emu/g. The batch adsorption study of lead (Pb) and chromium (Cr) from 20% fly ash aqueous solutions was carried out by using 0.6 mg/100 mL IONPs, which exhibited maximum removal efficiency i.e., 97.96% and 82.8% for Pb2+ and Cr ions, respectively. The fly ash are being used in making cements, tiles, bricks, bio fertilizers etc., where the presence of fly ash is undesired property which has to be either removed or will be brought up to the value of acceptable level in the fly ash. Therefore, the synthesized IONPs, can be applied in the elimination of heavy metals and other undesired elements from fly ash with a short period of time. Moreover, the IONPs that have been used as a nanoadsorbent can be recovered from the reaction mixture by applying an external magnetic field that can be recycled and reused. Therefore, this study can be effective in all the fly ash-based industries for elimination of the undesired elements, while recyclability and reusable nature of IONPs will make the whole adsorption or elimination process much economical.

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Section: Vibrating Sample Magnetometer (Vsm) (Magnetization Study)mentioning

confidence: 81%

Section: Vibrating Sample Magnetometer (Vsm) (Magnetization Study)mentioning

confidence: 88%

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

et al. 2020

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“…High magnetization and hysteretic heating make them potential candidates in separation and biomedical areas, and the semiconducting property and chemically active surface allow catalytic activities such as photocatalytic ability [ 8 , 9 ]. Iron oxide nanoparticles (IONPs) have a broad range of significant applications in electronics [ 10 , 11 ], biomedicine [ 12 , 13 , 14 ], energy [ 15 , 16 ], agriculture [ 17 , 18 ], and animal biotechnology [ 19 , 20 ], as shown in Figure 1 . In a small size of about 10–20 nm, the superparamagnetic properties of Fe 3 O 4 and γ-Fe 2 O 3 nanoparticles become apparent, therefore, better performance can be achieved for the above-mentioned applications.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future

et al. 2020

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Iron oxides are chemical compounds which have different polymorphic forms, including γ-Fe2O3 (maghemite), Fe3O4 (magnetite), and FeO (wustite). Among them, the most studied are γ-Fe2O3 and Fe3O4, as they possess extraordinary properties at the nanoscale (such as super paramagnetism, high specific surface area, biocompatible etc.), because at this size scale, the quantum effects affect matter behavior and optical, electrical and magnetic properties. Therefore, in the nanoscale, these materials become ideal for surface functionalization and modification in various applications such as separation techniques, magnetic sorting (cells and other biomolecules etc.), drug delivery, cancer hyperthermia, sensing etc., and also for increased surface area-to-volume ratio, which allows for excellent dispersibility in the solution form. The current methods used are partially and passively mixed reactants, and, thus, every reaction has a different proportion of all factors which causes further difficulties in reproducibility. Direct active and complete mixing and automated approaches could be solutions to this size- and shape-controlled synthesis, playing a key role in its exploitation for scientific or technological purposes. An ideal synthesis method should be able to allow reliable adjustment of parameters and control over the following: fluctuation in temperature; pH, stirring rate; particle distribution; size control; concentration; and control over nanoparticle shape and composition i.e., crystallinity, purity, and rapid screening. Iron oxide nanoparticle (IONP)-based available clinical applications are RNA/DNA extraction and detection of infectious bacteria and viruses. Such technologies are important at POC (point of care) diagnosis. IONPs can play a key role in these perspectives. Although there are various methods for synthesis of IONPs, one of the most crucial goals is to control size and properties with high reproducibility to accomplish successful applications. Using multiple characterization techniques to identify and confirm the oxide phase of iron can provide better characterization capability. It is very important to understand the in-depth IONP formation mechanism, enabling better control over parameters and overall reaction and, by extension, properties of IONPs. This work provides an in-depth overview of different properties, synthesis methods, and mechanisms of iron oxide nanoparticles (IONPs) formation, and the diverse range of their applications. Different characterization factors and strategies to confirm phase purity in the IONP synthesis field are reviewed. First, properties of IONPs and various synthesis routes with their merits and demerits are described. We also describe different synthesis strategies and formation mechanisms for IONPs such as for: wustite (FeO), hematite (α-Fe2O3), maghemite (ɤ-Fe2O3) and magnetite (Fe3O4). We also describe characterization of these nanoparticles and various applications in detail. In conclusion, we present a detailed overview on the properties, size-controlled synthesis, formation mechanisms and applications of IONPs.

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“…In vitro evaluation on iron oxide nanorods and nanospheres carried out in human carcinoma cells indicated that hematite nanorods were more quickly and in a higher extend internalized than nanospheres [13]. The more favorable cellular uptake of rod-shaped NPs, as opposed to spherical NPs, Andrade et al [14], explained with the larger area of contact between the cell membrane and rod-shaped NP. Comparing tripod with spherical iron oxide NPs, it has been found that tripod particles had lower cytotoxicity in HeLa and Hepa 1-6 cells at concentrations between 0.022 and 0.35 mg Fe/mL [15].…”

Section: Shape and Sizementioning

confidence: 99%

Metal Oxide Nanoparticles as Biomedical Materials

Nikolova

Chavali²

2020

Biomimetics

338

146

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The development of new nanomaterials with high biomedical performance and low toxicity is essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently, scientists often face issues of balancing between positive therapeutic effects of metal oxide nanoparticles and their toxic side effects. In this review, considering metal oxide nanoparticles as important technological and biomedical materials, the authors provide a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine. Authors discuss the recent development of metal oxide nanoparticles that were employed as biomedical materials in tissue therapy, immunotherapy, diagnosis, dentistry, regenerative medicine, wound healing and biosensing platforms. Besides, their antimicrobial, antifungal, antiviral properties along with biotoxicology were debated in detail. The significant breakthroughs in the field of nanobiomedicine have emerged in areas and numbers predicting tremendous application potential and enormous market value for metal oxide nanoparticles.

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Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Cited by 130 publications

References 194 publications

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

Synthesis and Characterization of Amorphous Iron Oxide Nanoparticles by the Sonochemical Method and Their Application for the Remediation of Heavy Metals from Wastewater

Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future

Metal Oxide Nanoparticles as Biomedical Materials

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