Shaping the scaling characteristics of gap gene expression patterns in Drosophila

Xu, Ruoqing; Dai, Fei; Wu, Honggang; Jiao, Renjie; He, Feng; Ma, Jun

doi:10.1016/j.heliyon.2023.e13623

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e13623

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Shaping the scaling characteristics of gap gene expression patterns in Drosophila

Ruoqing Xu¹,

Fei Dai²,

Honggang Wu³

et al.

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2024

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References 80 publications

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Scale invariance in early embryonic development

Nikolić,

Antonetti,

Liu

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

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The expression of a few key genes determines the body plan of the fruit fly. We show that the spatial expression patterns for several of these genes scale precisely with embryo size. Discrete positional markers such as the peaks in striped patterns or the boundaries of expression domains have positions along the embryo’s major axis proportional to embryo length, accurate to within 1%. Further, the information (in bits) that graded patterns of expression provide about a cell’s position can be decomposed into information about fractional or scaled position and information about absolute position or embryo length; all information available is about scaled position, with < 2% error. These findings imply that the underlying genetic network’s behavior exhibits scale invariance in a more precise mathematical sense. We argue that models that can explain this scale invariance also have a “zero mode” in the dynamics of gene expression, and this connects to observations on the spatial correlation of fluctuations in expression levels.

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Scale invariance in early embryonic development

Nikolić,

Antonetti,

Liu

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

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Shaping the scaling characteristics of gap gene expression patterns in Drosophila

Cited by 1 publication

References 80 publications

Scale invariance in early embryonic development

Scale invariance in early embryonic development

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