Sharing lessons learnt across European cardiovascular research consortia

Jong, L de; Bobeldijk-Pastorova, Ivana; Erdmann, Jeanette; Bijker-Schreurs, Marijke; Schunkert, Heribert; Kuivenhoven, Jan Albert; Gool, Alain J. van

doi:10.1016/j.drudis.2020.01.009

Cited by 1 publication

(1 citation statement)

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“…CVD affects the heart and its blood vessels, causing myocardial infarction, heart failure, and stroke; it constitutes one of the primary causes of death worldwide [ 5 ]. Metabolic dysfunction in the microenvironment of organisms is a fundamental core mechanism underlying CVD.…”

Section: Backgroudmentioning

confidence: 99%

A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Wang

Gao

et al. 2021

Immun Ageing

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Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer’s disease (AD) and cardiovascular disease (CVD). The central dogma of molecular biology demonstrates the conversion of DNA to RNA to the encoded protein. These proteins interact to form complex cell signaling pathways, which perform various biological functions. With prolonged exposure to the environment, the in vivo homeostasis adapts to the changes, and finally, humans adopt the phenotype of longevity or aging-related diseases. In this review, we focus on two different states: longevity and aging-related diseases, including CVD and AD, to discuss the relationship between genetic characteristics, including gene variation, the level of gene expression, regulation of gene expression, the level of protein expression, both genetic and environmental influences and homeostasis based on these phenotypes shown in organisms.

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Section: Backgroudmentioning

confidence: 99%