Shark VNAR phage display libraries: An alternative source for therapeutic and diagnostic recombinant antibody fragments

Manoutcharian, Karen; Gevorkian, Goar

doi:10.1016/j.fsi.2023.108808

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…Camel-derived CD16a-specific antibodies conjugated with anti-CEA antibodies have effectively inhibited CEA-positive tumor growth ( 33 ), and nanobodies against EpCAM have significantly reduced MCF-4 cell proliferation ( 34 ). A VNAR antibody library from nurse sharks yielded antibodies binding to GPC3, HER2, and PD-1 ( 35 ), demonstrating phage display’s potential despite immunogenicity concerns ( 36 ). The phage display targets crucial cancer biomarkers and therapy targets like EGFR ( 37 ), its mutant EGFRvIII ( 38 , 39 ).…”

Section: Applications Of Phage Display In Cancer Researchmentioning

confidence: 99%

Advancements in ovarian cancer immunodiagnostics and therapeutics via phage display technology

Li,

Yang

et al. 2024

Front. Immunol.

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Ovarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties in early detection are amplified by the limitations and inefficacies inherent in current screening methodologies, highlighting a pressing need for more efficacious diagnostic and treatment strategies. Phage display technology emerges as a pivotal innovation in this context, utilizing extensive phage-peptide libraries to identify ligands with specificity for cancer cell markers, thus enabling precision-targeted therapeutic strategies. This technology promises a paradigm shift in ovarian cancer management, concentrating on targeted drug delivery systems to improve treatment accuracy and efficacy while minimizing adverse effects. Through a meticulous review, this paper evaluates the revolutionary potential of phage display in enhancing ovarian cancer therapy, representing a significant advancement in combating this challenging disease. Phage display technology is heralded as an essential instrument for developing effective immunodiagnostic and therapeutic approaches in ovarian cancer, facilitating early detection, precision-targeted medication, and the implementation of customized treatment plans.

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