Shear Stress and Atherosclerosis

Heo, Kyung‐Sun; Fujiwara, Keigi; Abe, Jun

doi:10.14348/molcells.2014.0078

Cited by 137 publications

(100 citation statements)

References 56 publications

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“…This force modulates endothelial function and, if altered, exerts a detrimental effect on cardiovascular health. However, little is known about the endothelium-specific response to wall shear stress within the pulmonary vasculature and its role in the pathogenesis and progression of pulmonary vascular diseases (5,6).…”

Section: Introductionmentioning

confidence: 99%

Biomarker and shear stress in secondary pediatric pulmonary hypertension

Pektas¹,

Olguntürk²,

Kula³

et al. 2017

Turk J Med Sci

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Section: Introductionmentioning

confidence: 99%

Biomarker and shear stress in secondary pediatric pulmonary hypertension

Pektas¹,

Olguntürk²,

Kula³

et al. 2017

Turk J Med Sci

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“…Emerging evidence has provided new insights into the cellular mechanisms of flow-dependent regulation of vascular function that leads to cardiovascular events such as atherosclerosis, atherothrombosis, and myocardial infarction. 25) Endothelial dysfunction caused by disturbed flow is thought to be one of the primary culprits in the progression of atherosclerosis. Time rate of BP variation, as an index of shear stress in the vessel wall, may pose a great threat to endothelial cells in certain signal pathways, including inflammation and oxidative stress, and further promote platelet aggregation and plaque formation.…”

Section: Discussionmentioning

confidence: 99%

Time Rate of Blood Pressure Variation Is Associated With Endothelial Function in Patients With Metabolic Syndrome

et al. 2016

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SummaryThe time rate of blood pressure (BP) variation indicates the speed of BP fluctuations. Previous studies have demonstrated that the time rate of BP variation was associated with target organ damage. However, the association between time rate of BP variation and endothelial function has not been evaluated.24-hour ambulatory blood pressure monitoring (ABPM) was performed in 61 patients with metabolic syndrome. Time rate of BP variation was calculated from BP recordings of ABPM. Endothelial function was assessed using reactive hyperemia-peripheral arterial tonometry index (RHI) by EndoPat2000. Multiple linear regression models were used to detect the association between time rate of BP variation and RHI.Among all the subjects (n = 61), the multiple linear regression models revealed that the daytime rate of systolic blood pressure (SBP) variation was independently associated with RHI (β = -0.334, P = 0.008). A 0.1 mmHg/minute increase in the daytime rate of SBP variation correlated with a decline of 0.20 in RHI. The same effect was also found in the subjects with eGFR ≥ 60 mL/ (minute*1.73 m 2 ). A greater association was found in those who were not taking a statin, β-blocker, ACEI/ARB, or diuretic and those without diabetes compared with those with any antihypertensive medication or with diabetes. Other ambulatory blood pressure parameters and central hemodynamics were not found to be associated with RHI.Our findings have shown that the daytime rate of SBP variation was associated with endothelial function in patients with metabolic syndrome, independent of other BP parameters and central hemodynamics. (Int Heart J 2016; 57: 226-233) Key words: RHI, Ambulatory blood pressure monitoring, Target organ damage, Blood pressure variability A mbulatory blood pressure monitoring (ABPM) is widely used in patients with prehypertension and hypertension, and its use is gradually increasing. Many studies have suggested that systolic blood pressure (BP), diastolic BP, and the degree of BP variability (BPV) calculated from ABPM are associated with target organ damage, cardiovascular disease risk, and long-term prognosis.1,2) Mancia, et al described a new BP phenomenon called time rate of BP variation, which is a measure of the speed of BP fluctuations derived from a computerized analysis of ABPM data.3) Current evidence has suggested that the time rate of BP variation was associated with target organ damage, such as increased common carotid artery intima-media thickness, 4,5) increased left ventricular mass, 6) impaired renal function, 7) and coronary atherosclerosis. 8)Endothelial dysfunction is one of the important pathophysiological processes of the early stage in patients with metabolic syndrome (MetS), and is an early manifestation before atherosclerotic plaque detected by angiography or ultrasound, 9) and is a sign of poor cardiovascular prognosis.10) Early detection of endothelial dysfunction has attracted more and more attention in clinical practice. Reactive hyperemia-peripheral arterial tonometry index (RHI) is...

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“…The disturbance of laminar blood flow in certain nonlinear vascular segments is thought to facilitate atherosclerotic progression through promoting shear stress-induced endothelial dysfunction [21,22]. In particular, Heo et al [23] demonstrated that disturbed laminar flow downregulates endothelial cell production of the enzyme eNOS.…”

Section: Discussionmentioning

confidence: 99%

Injection of hTERT-Transduced Endothelial Progenitor Cells Promotes Beneficial Aortic Changes in a High-Fat Dietary Model of Early Atherosclerosis

Deng²,

Zhao³

et al. 2016

Cardiology

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Objectives: Cultured endothelial progenitor cells (EPCs) display troubling issues that adversely affect their applicability to endothelial regeneration. We hypothesized that transduction of the human telomerase catalytic subunit (hTERT) gene would enhance EPC function in treating dietary-induced early atherosclerosis (AS). Methods: A dietary-induced early AS model was successfully constructed in 90 healthy male rats, while 30 healthy control (HC) rats were normally fed. Four experimental groups were constructed: an untreated HC group; an untreated AS group injected with PBS; a null EPC AS group injected with null vector-transduced EPCs, and an hTERT EPC AS group injected with hTERT-transduced EPCs. Two months postinjection, abdominal aortas were extracted to validate EPC integration and comparatively assess mRNA and protein expression of the early atherosclerotic markers VCAM-1, ICAM-1, LFA-1, Mac-1, CD44, MCP-1, endothelial nitric oxide synthase (eNOS), and apolipoprotein E. Results: In vitro, hTERT transduction of EPCs resulted in a significantly superior proliferative capacity as well as significantly higher NO, iNOS, and LDH secretory capacity. In vivo injection of hTERT-transduced EPCs produced significant reductions in CD44 and MCP-1 expression as well as a significant increase in eNOS expression relative to injection with null vector-transduced EPCs (all p < 0.05). Conclusion: hTERT-transduced human EPCs may be useful in treating dietary-induced early AS.

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Shear Stress and Atherosclerosis

Cited by 137 publications

References 56 publications

Biomarker and shear stress in secondary pediatric pulmonary hypertension

Biomarker and shear stress in secondary pediatric pulmonary hypertension

Time Rate of Blood Pressure Variation Is Associated With Endothelial Function in Patients With Metabolic Syndrome

Injection of hTERT-Transduced Endothelial Progenitor Cells Promotes Beneficial Aortic Changes in a High-Fat Dietary Model of Early Atherosclerosis

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